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In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis.

Computers in biology and medicine

Gerber M, Goel S, Maitra R.
PMID: 34920161
Comput Biol Med. 2021 Dec 09;141:105110. doi: 10.1016/j.compbiomed.2021.105110. Epub 2021 Dec 09.

KRAS mutation is prevalent in around 30% of all cancers and is an undruggable molecular target. Of seven mutations at codon 12 and 13, only one, the G12C mutant is finally proven to be druggable, as evidenced by the...

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Gerber M, Goel S, Maitra R. In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis. Comput Biol Med. 2021;141:105110doi: 10.1016/j.compbiomed.2021.105110.
Gerber, M., Goel, S., & Maitra, R. (2021). In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis. Computers in biology and medicine, 141105110. https://doi.org/10.1016/j.compbiomed.2021.105110
Gerber, Michael, et al. "In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis." Computers in biology and medicine vol. 141 (2021): 105110. doi: https://doi.org/10.1016/j.compbiomed.2021.105110
Gerber M, Goel S, Maitra R. In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis. Comput Biol Med. 2021 Dec 09;141:105110. doi: 10.1016/j.compbiomed.2021.105110. Epub 2021 Dec 09. PMID: 34920161.
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Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells.

Cell reports

Zeng F, Li X, Pires-Alves M, Chen X, Hawk CW, Jin H.
PMID: 34706231
Cell Rep. 2021 Oct 26;37(4):109877. doi: 10.1016/j.celrep.2021.109877.

Conserved developmentally regulated guanosine triphosphate (GTP)-binding proteins (Drgs) and their binding partner Drg family regulatory proteins (Dfrps) are important for embryonic development, cellular growth control, differentiation, and proliferation. Here, we report that the yeast Drg1/Dfrp1 ortholog Rbg1/Tma46 facilitates translational...

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Zeng F, Li X, Pires-Alves M, et al. Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells. Cell Rep. 2021;37(4):109877doi: 10.1016/j.celrep.2021.109877.
Zeng, F., Li, X., Pires-Alves, M., Chen, X., Hawk, C. W., & Jin, H. (2021). Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells. Cell reports, 37(4), 109877. https://doi.org/10.1016/j.celrep.2021.109877
Zeng, Fuxing, et al. "Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells." Cell reports vol. 37,4 (2021): 109877. doi: https://doi.org/10.1016/j.celrep.2021.109877
Zeng F, Li X, Pires-Alves M, Chen X, Hawk CW, Jin H. Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells. Cell Rep. 2021 Oct 26;37(4):109877. doi: 10.1016/j.celrep.2021.109877. PMID: 34706231.
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Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP.

Journal of structural biology

Ebenhoch R, Bauer M, Reinert D, Kersting A, Huber S, Schmid A, Hinz I, Feiler M, Müller K, Nar H.
PMID: 33387654
J Struct Biol. 2021 Mar;213(1):107691. doi: 10.1016/j.jsb.2020.107691. Epub 2020 Dec 31.

GTP Cyclohydrolase I (GCH1) catalyses the conversion of guanosine triphosphate (GTP) to dihydroneopterin triphosphate (H2NTP), the initiating step in the biosynthesis of tetrahydrobiopterin (BH4). BH4 functions as co-factor in neurotransmitter biosynthesis. BH4 homeostasis is a promising target to treat...

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Ebenhoch R, Bauer M, Reinert D, et al. Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP. J Struct Biol. 2020;213(1):107691doi: 10.1016/j.jsb.2020.107691.
Ebenhoch, R., Bauer, M., Reinert, D., Kersting, A., Huber, S., Schmid, A., Hinz, I., Feiler, M., Müller, K., & Nar, H. (2021). Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP. Journal of structural biology, 213(1), 107691. https://doi.org/10.1016/j.jsb.2020.107691
Ebenhoch, Rebecca, et al. "Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP." Journal of structural biology vol. 213,1 (2021): 107691. doi: https://doi.org/10.1016/j.jsb.2020.107691
Ebenhoch R, Bauer M, Reinert D, Kersting A, Huber S, Schmid A, Hinz I, Feiler M, Müller K, Nar H. Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP. J Struct Biol. 2021 Mar;213(1):107691. doi: 10.1016/j.jsb.2020.107691. Epub 2020 Dec 31. PMID: 33387654.
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Inherited Platelet Function Disorder From Novel Mutations in RAS Guanyl-Releasing Protein-2 Confirmed by Sanger Sequencing.

Cureus

Al-Hebshi A.
PMID: 33391941
Cureus. 2020 Nov 25;12(11):e11708. doi: 10.7759/cureus.11708.

Inherited platelet disorders (IPDs) are genetically heterogeneous rare disorders due to quantitative and/or qualitative abnormalities of the platelet. IPDs are often predisposed to significant medical complications. RAS guanyl-releasing protein-2 (RASGRP2) was recently identified as a gene affected in patients...

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Al-Hebshi A. Inherited Platelet Function Disorder From Novel Mutations in RAS Guanyl-Releasing Protein-2 Confirmed by Sanger Sequencing. Cureus. 2020;12(11):e11708doi: 10.7759/cureus.11708.
Al-Hebshi, A. (2020). Inherited Platelet Function Disorder From Novel Mutations in RAS Guanyl-Releasing Protein-2 Confirmed by Sanger Sequencing. Cureus, 12(11), e11708. https://doi.org/10.7759/cureus.11708
Al-Hebshi, Abdulqader. "Inherited Platelet Function Disorder From Novel Mutations in RAS Guanyl-Releasing Protein-2 Confirmed by Sanger Sequencing." Cureus vol. 12,11 (2020): e11708. doi: https://doi.org/10.7759/cureus.11708
Al-Hebshi A. Inherited Platelet Function Disorder From Novel Mutations in RAS Guanyl-Releasing Protein-2 Confirmed by Sanger Sequencing. Cureus. 2020 Nov 25;12(11):e11708. doi: 10.7759/cureus.11708. PMID: 33391941; PMCID: PMC7769792.
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Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma.

Pharmaceutics

Trebucq LL, Cardama GA, Lorenzano Menna P, Golombek DA, Chiesa JJ, Marpegan L.
PMID: 34371781
Pharmaceutics. 2021 Jul 16;13(7). doi: 10.3390/pharmaceutics13071091.

The Ras homologous family of small guanosine triphosphate-binding enzymes (GTPases) is critical for cell migration and proliferation. The novel drug 1A-116 blocks the interaction site of the Ras-related C3 botulinum toxin substrate 1 (RAC1) GTPase with some of its...

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Trebucq LL, Cardama GA, Lorenzano Menna P, et al. Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma. Pharmaceutics. 2021;13(7)doi: 10.3390/pharmaceutics13071091.
Trebucq, L. L., Cardama, G. A., Lorenzano Menna, P., Golombek, D. A., Chiesa, J. J., & Marpegan, L. (2021). Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma. Pharmaceutics, 13(7), . https://doi.org/10.3390/pharmaceutics13071091
Trebucq, Laura Lucía, et al. "Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma." Pharmaceutics vol. 13,7 (2021). doi: https://doi.org/10.3390/pharmaceutics13071091
Trebucq LL, Cardama GA, Lorenzano Menna P, Golombek DA, Chiesa JJ, Marpegan L. Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma. Pharmaceutics. 2021 Jul 16;13(7). doi: 10.3390/pharmaceutics13071091. PMID: 34371781; PMCID: PMC8309043.
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Interferon-gamma - Inducible Inflammation: Contribution to Aging and Aging-Associated Psychiatric Disorders.

Aging and disease

Oxenkrug G.
PMID: 22396896
Aging Dis. 2011 Dec;2(6):474-86. Epub 2011 Dec 02.

Aging is associated with the chronic, low grade, Th-1 type inflammation. The key Th-1 type, pro-inflammatory cytokine, interferon-gamma (IFNG), transcriptionally induces the rate-limiting enzyme of tryptophan (TRY) - kynurenine (KYN) pathway, indoleamine 2,3- dioxygenase (IDO). Activation of IDO shunts...

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Oxenkrug G. Interferon-gamma - Inducible Inflammation: Contribution to Aging and Aging-Associated Psychiatric Disorders. Aging Dis. 2011;2(6):474-86
Oxenkrug, G. (2011). Interferon-gamma - Inducible Inflammation: Contribution to Aging and Aging-Associated Psychiatric Disorders. Aging and disease, 2(6), 474-86.
Oxenkrug, Gregory. "Interferon-gamma - Inducible Inflammation: Contribution to Aging and Aging-Associated Psychiatric Disorders." Aging and disease vol. 2,6 (2011): 474-86.
Oxenkrug G. Interferon-gamma - Inducible Inflammation: Contribution to Aging and Aging-Associated Psychiatric Disorders. Aging Dis. 2011 Dec;2(6):474-86. Epub 2011 Dec 02. PMID: 22396896; PMCID: PMC3295064.
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Chemical capping improves template switching and enhances sequencing of small RNAs.

Nucleic acids research

Wulf MG, Maguire S, Dai N, Blondel A, Posfai D, Krishnan K, Sun Z, Guan S, Corrêa IR.
PMID: 34581823
Nucleic Acids Res. 2022 Jan 11;50(1):e2. doi: 10.1093/nar/gkab861.

Template-switching reverse transcription is widely used in RNA sequencing for low-input and low-quality samples, including RNA from single cells or formalin-fixed paraffin-embedded (FFPE) tissues. Previously, we identified the native eukaryotic mRNA 5' cap as a key structural element for...

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Wulf MG, Maguire S, Dai N, et al. Chemical capping improves template switching and enhances sequencing of small RNAs. Nucleic Acids Res. 2022;50(1):e2doi: 10.1093/nar/gkab861.
Wulf, M. G., Maguire, S., Dai, N., Blondel, A., Posfai, D., Krishnan, K., Sun, Z., Guan, S., & Corrêa, I. R. (2022). Chemical capping improves template switching and enhances sequencing of small RNAs. Nucleic acids research, 50(1), e2. https://doi.org/10.1093/nar/gkab861
Wulf, Madalee G, et al. "Chemical capping improves template switching and enhances sequencing of small RNAs." Nucleic acids research vol. 50,1 (2022): e2. doi: https://doi.org/10.1093/nar/gkab861
Wulf MG, Maguire S, Dai N, Blondel A, Posfai D, Krishnan K, Sun Z, Guan S, Corrêa IR. Chemical capping improves template switching and enhances sequencing of small RNAs. Nucleic Acids Res. 2022 Jan 11;50(1):e2. doi: 10.1093/nar/gkab861. PMID: 34581823; PMCID: PMC8754658.
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Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis.

Biomolecules & therapeutics

Zhang X, Kim KM.
PMID: 28035080
Biomol Ther (Seoul). 2017 Jan 01;25(1):26-43. doi: 10.4062/biomolther.2016.186.

Endocytosis is a process by which cells absorb extracellular materials via the inward budding of vesicles formed from the plasma membrane. Receptor-mediated endocytosis is a highly selective process where receptors with specific binding sites for extracellular molecules internalize via...

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Zhang X, Kim KM. Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis. Biomol Ther (Seoul). 2017;25(1):26-43doi: 10.4062/biomolther.2016.186.
Zhang, X., & Kim, K. M. (2017). Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis. Biomolecules & therapeutics, 25(1), 26-43. https://doi.org/10.4062/biomolther.2016.186
Zhang, Xiaohan, and Kim, Kyeong-Man. "Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis." Biomolecules & therapeutics vol. 25,1 (2017): 26-43. doi: https://doi.org/10.4062/biomolther.2016.186
Zhang X, Kim KM. Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis. Biomol Ther (Seoul). 2017 Jan 01;25(1):26-43. doi: 10.4062/biomolther.2016.186. PMID: 28035080; PMCID: PMC5207461.
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Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia.

CNS drugs

Mould AW, Al-Juffali N, von Delft A, Brennan PE, Tunbridge EM.
PMID: 34928485
CNS Drugs. 2022 Jan;36(1):1-16. doi: 10.1007/s40263-021-00884-z. Epub 2021 Dec 20.

The cognitive dysfunction experienced by patients with schizophrenia represents a major unmet clinical need. We believe that enhancing synaptic function and plasticity by targeting kalirin may provide a novel means to remediate these symptoms. Karilin (a protein encoded by...

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Mould AW, Al-Juffali N, von Delft A, et al. Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia. CNS Drugs. 2021;36(1):1-16doi: 10.1007/s40263-021-00884-z.
Mould, A. W., Al-Juffali, N., von Delft, A., Brennan, P. E., & Tunbridge, E. M. (2022). Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia. CNS drugs, 36(1), 1-16. https://doi.org/10.1007/s40263-021-00884-z
Mould, Arne W, et al. "Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia." CNS drugs vol. 36,1 (2022): 1-16. doi: https://doi.org/10.1007/s40263-021-00884-z
Mould AW, Al-Juffali N, von Delft A, Brennan PE, Tunbridge EM. Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia. CNS Drugs. 2022 Jan;36(1):1-16. doi: 10.1007/s40263-021-00884-z. Epub 2021 Dec 20. PMID: 34928485.
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Chemical capping improves template switching and enhances sequencing of small RNAs.

Nucleic acids research

Wulf MG, Maguire S, Dai N, Blondel A, Posfai D, Krishnan K, Sun Z, Guan S, Corrêa IR.
PMID: 34581823
Nucleic Acids Res. 2021 Sep 28; doi: 10.1093/nar/gkab861. Epub 2021 Sep 28.

Template-switching reverse transcription is widely used in RNA sequencing for low-input and low-quality samples, including RNA from single cells or formalin-fixed paraffin-embedded (FFPE) tissues. Previously, we identified the native eukaryotic mRNA 5' cap as a key structural element for...

Cite
Wulf MG, Maguire S, Dai N, et al. Chemical capping improves template switching and enhances sequencing of small RNAs. Nucleic Acids Res. 2021;doi: 10.1093/nar/gkab861.
Wulf, M. G., Maguire, S., Dai, N., Blondel, A., Posfai, D., Krishnan, K., Sun, Z., Guan, S., & Corrêa, I. R. (2021). Chemical capping improves template switching and enhances sequencing of small RNAs. Nucleic acids research, . https://doi.org/10.1093/nar/gkab861
Wulf, Madalee G, et al. "Chemical capping improves template switching and enhances sequencing of small RNAs." Nucleic acids research vol. (2021). doi: https://doi.org/10.1093/nar/gkab861
Wulf MG, Maguire S, Dai N, Blondel A, Posfai D, Krishnan K, Sun Z, Guan S, Corrêa IR. Chemical capping improves template switching and enhances sequencing of small RNAs. Nucleic Acids Res. 2021 Sep 28; doi: 10.1093/nar/gkab861. Epub 2021 Sep 28. PMID: 34581823.
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RAPID AND SIMULTANEOUS MEASUREMENT OF ANODIC AND CATHODIC HAEMOGLOBINS AND ATP AND GTP CONCENTRATIONS IN MINUTE QUANTITIES OF FISH BLOOD.

The Journal of experimental biology

Feuerlein R, Weber R.
PMID: 9317794
J Exp Biol. 1994 Apr;189(1):273-7.

Oxygen transport to vertebrate tissues is dependent upon (a) the intrinsic O2-binding properties of haemoglobin (Hb) and (b) modulation by allosteric effectors, such as nucleoside triphosphates (NTP), that depress Hb O2-affinity in fish red cells. While some species, such...

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Feuerlein R, Weber R. RAPID AND SIMULTANEOUS MEASUREMENT OF ANODIC AND CATHODIC HAEMOGLOBINS AND ATP AND GTP CONCENTRATIONS IN MINUTE QUANTITIES OF FISH BLOOD. J Exp Biol. 1994;189(1):273-7
Feuerlein, R., & Weber, R. (1994). RAPID AND SIMULTANEOUS MEASUREMENT OF ANODIC AND CATHODIC HAEMOGLOBINS AND ATP AND GTP CONCENTRATIONS IN MINUTE QUANTITIES OF FISH BLOOD. The Journal of experimental biology, 189(1), 273-7.
Feuerlein, and Weber. "RAPID AND SIMULTANEOUS MEASUREMENT OF ANODIC AND CATHODIC HAEMOGLOBINS AND ATP AND GTP CONCENTRATIONS IN MINUTE QUANTITIES OF FISH BLOOD." The Journal of experimental biology vol. 189,1 (1994): 273-7.
Feuerlein R, Weber R. RAPID AND SIMULTANEOUS MEASUREMENT OF ANODIC AND CATHODIC HAEMOGLOBINS AND ATP AND GTP CONCENTRATIONS IN MINUTE QUANTITIES OF FISH BLOOD. J Exp Biol. 1994 Apr;189(1):273-7. PMID: 9317794.
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The dynamic structure of Rab35 is stabilized in the presence of GTP under physiological conditions.

Biochemistry and biophysics reports

Murata T, Unno Y, Fukuda M, Utsunomiya-Tate N.
PMID: 32613087
Biochem Biophys Rep. 2020 Jun 24;23:100776. doi: 10.1016/j.bbrep.2020.100776. eCollection 2020 Sep.

Rab proteins, a family of small guanosine triphosphatases, play key roles in intracellular membrane trafficking and the regulation of various cellular processes. As a Rab isoform, Rab35 is crucial for recycling endosome trafficking, cytokinesis and neurite outgrowth. In this...

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Murata T, Unno Y, Fukuda M, et al. The dynamic structure of Rab35 is stabilized in the presence of GTP under physiological conditions. Biochem Biophys Rep. 2020;23:100776doi: 10.1016/j.bbrep.2020.100776.
Murata, T., Unno, Y., Fukuda, M., & Utsunomiya-Tate, N. (2020). The dynamic structure of Rab35 is stabilized in the presence of GTP under physiological conditions. Biochemistry and biophysics reports, 23100776. https://doi.org/10.1016/j.bbrep.2020.100776
Murata, Takuya, et al. "The dynamic structure of Rab35 is stabilized in the presence of GTP under physiological conditions." Biochemistry and biophysics reports vol. 23 (2020): 100776. doi: https://doi.org/10.1016/j.bbrep.2020.100776
Murata T, Unno Y, Fukuda M, Utsunomiya-Tate N. The dynamic structure of Rab35 is stabilized in the presence of GTP under physiological conditions. Biochem Biophys Rep. 2020 Jun 24;23:100776. doi: 10.1016/j.bbrep.2020.100776. eCollection 2020 Sep. PMID: 32613087; PMCID: PMC7322127.
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Showing 25 to 36 of 144 entries