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Showing 25 to 36 of 3070 entries
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A combined antral and corpus rapid urease testing protocol can increase diagnostic accuracy despite a low prevalence of Helicobacter pylori infection in patients undergoing routine gastroscopy.

United European gastroenterology journal

Parihar V, Holleran G, Hall B, Brennan D, Crotty P, McNamara D.
PMID: 26535121
United European Gastroenterol J. 2015 Oct;3(5):432-6. doi: 10.1177/2050640615573374.

BACKGROUND: The effects of an increased risk of sampling error and the lower prevalence of Helicobacter pylori infection on the diagnostic accuracy of standard invasive tests needs to be considered. Despite evidence of enhanced yield with additional biopsies, combined...

Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame.

Biochimica et biophysica acta

Gentry LR, Martin TD, Reiner DJ, Der CJ.
PMID: 25219551
Biochim Biophys Acta. 2014 Dec;1843(12):2976-2988. doi: 10.1016/j.bbamcr.2014.09.004. Epub 2014 Sep 16.

Since their discovery in 1986, Ral (Ras-like) GTPases have emerged as critical regulators of diverse cellular functions. Ral-selective guanine nucleotide exchange factors (RalGEFs) function as downstream effectors of the Ras oncoprotein, and the RalGEF-Ral signaling network comprises the third...

Simulation of Adsorption Processes at Metallic Interfaces: An Image Charge Augmented QM/MM Approach.

Journal of chemical theory and computation

Golze D, Iannuzzi M, Nguyen MT, Passerone D, Hutter J.
PMID: 26583423
J Chem Theory Comput. 2013 Nov 12;9(11):5086-97. doi: 10.1021/ct400698y. Epub 2013 Oct 11.

A novel method for including polarization effects within hybrid quantum mechanics/molecular mechanics (QM/MM) simulations of adsorbate-metal systems is presented. The interactions between adsorbate (QM) and metallic substrate (MM) are described at the MM level of theory. Induction effects are...

Structure-based identification of functional residues in the nucleoside-2'-O-methylase domain of Bluetongue virus VP4 capping enzyme.

FEBS open bio

Stewart ME, Roy P.
PMID: 25834778
FEBS Open Bio. 2015 Feb 24;5:138-46. doi: 10.1016/j.fob.2015.02.001. eCollection 2015.

Bluetongue virus (BTV) encodes a single capping protein, VP4, which catalyzes all reactions required to generate cap1 structures on nascent viral transcripts. Further, structural analysis by X-ray crystallography indicated each catalytic reaction is arranged as a discrete domain, including...

Theoretical Determination of One-Electron Oxidation Potentials for Nucleic Acid Bases.

Journal of chemical theory and computation

Psciuk BT, Lord RL, Munk BH, Schlegel HB.
PMID: 26593200
J Chem Theory Comput. 2012 Dec 11;8(12):5107-23. doi: 10.1021/ct300550x. Epub 2012 Sep 13.

The oxidation potentials for N-methyl substituted nucleic acid bases guanine, adenine, cytosine, thymine, uracil, xanthine, and 8-oxoguanine were computed using B3LYP and CBS-QB3 with the SMD solvation model. Acid-base and tautomeric equilibria present in aqueous solution were accounted for...

The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation.

Genes & cancer

Huff LP, Decristo MJ, Trembath D, Kuan PF, Yim M, Liu J, Cook DR, Miller CR, Der CJ, Cox AD.
PMID: 24386507
Genes Cancer. 2013 Nov;4(11):460-75. doi: 10.1177/1947601913514851.

Ect2, a Rho guanine nucleotide exchange factor (RhoGEF), is atypical among RhoGEFs in its predominantly nuclear localization in interphase cells. One current model suggests that Ect2 mislocalization drives cellular transformation by promoting aberrant activation of cytoplasmic Rho family GTPase...

Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue.

Neural regeneration research

Rosas OR, Torrado AI, Santiago JM, Rodriguez AE, Salgado IK, Miranda JD.
PMID: 25657738
Neural Regen Res. 2014 Dec 15;9(24):2164-73. doi: 10.4103/1673-5374.147949.

The spinal cord has the ability to regenerate but the microenvironment generated after trauma reduces that capacity. An increase in Src family kinase (SFK) activity has been implicated in neuropathological conditions associated with central nervous system trauma. Therefore, we...

TLR4 Asp299Gly (rs4986790) polymorphism and coronary artery disease: a meta-analysis.

PeerJ

Chen R, Gu N, Gao Y, Cen W.
PMID: 26644971
PeerJ. 2015 Nov 26;3:e1412. doi: 10.7717/peerj.1412. eCollection 2015.

UNLABELLED: Background. Previous studies have shown conflicting results on the association between toll-like receptor 4 (TLR4) Asp299Gly (rs4986790) polymorphism and coronary artery disease (CAD). The aim of this study was to evaluate the influence of TLR4 Asp299Gly polymorphism on...

Factorial validity and reliability of the Tamil version of multidimensional scale of perceived social support among a group of participants in university malaya medical centre, malaysia.

Indian journal of psychological medicine

Guan NC, Sulaiman AR, Seng LH, Ann AY, Wahab S, Pillai SK.
PMID: 24379500
Indian J Psychol Med. 2013 Oct;35(4):385-8. doi: 10.4103/0253-7176.122234.

BACKGROUND AND OBJECTIVES: This study was done to validate the Tamil version of Multidimensional Scale of Perceived Social Support (MSPSS-TV) among a group of Indian participants in University Malaya.MATERIALS AND METHODS: Ninety-four people who took part in this study...

Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.

Frontiers in pharmacology

Cahill E, Salery M, Vanhoutte P, Caboche J.
PMID: 24409148
Front Pharmacol. 2014 Jan 08;4:172. doi: 10.3389/fphar.2013.00172.

Despite their distinct targets, all addictive drugs commonly abused by humans evoke increases in dopamine (DA) concentration within the striatum. The main DA Guanine nucleotide binding protein couple receptors (GPCRs) expressed by medium-sized spiny neurons of the striatum are...

Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8.

Cilia

Schou KB, Morthorst SK, Christensen ST, Pedersen LB.
PMID: 25018876
Cilia. 2014 Jun 18;3:6. doi: 10.1186/2046-2530-3-6. eCollection 2014.

BACKGROUND: Assembly of primary cilia relies on vesicular trafficking towards the cilium base and intraflagellar transport (IFT) between the base and distal tip of the cilium. Recent studies have identified several key regulators of these processes, including Rab GTPases...

Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitro.

Frontiers in genetics

Williams JD, Fleetwood S, Berroyer A, Kim N, Larson ED.
PMID: 26029241
Front Genet. 2015 May 11;6:177. doi: 10.3389/fgene.2015.00177. eCollection 2015.

The formation of highly stable four-stranded DNA, called G-quadruplex (G4), promotes site-specific genome instability. G4 DNA structures fold from repetitive guanine sequences, and increasing experimental evidence connects G4 sequence motifs with specific gene rearrangements. The human transcription factor 3...

Showing 25 to 36 of 3070 entries