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Showing 25 to 36 of 2544 entries
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The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics.

Hereditary cancer in clinical practice

Sheikh A, Niazi AK, Ahmed MZ, Iqbal B, Anwer SM, Khan HH.
PMID: 24817919
Hered Cancer Clin Pract. 2014 Apr 22;12(1):13. doi: 10.1186/1897-4287-12-13. eCollection 2014.

The Wnt proteins are a family of 19 secreted glycoproteins that occupy crucial roles in the regulation of processes such as cell survival, proliferation, migration and polarity, cell fate specification, body axis patterning and self-renewal in stem cells. The...

Identification and characterization of transcriptional control region of the human beta 1,4-mannosyltransferase gene.

Cytotechnology

Takahashi T, Nedachi T, Etoh T, Tachikawa H, Gao XD.
PMID: 26608959
Cytotechnology. 2017 Jun;69(3):417-434. doi: 10.1007/s10616-015-9929-y. Epub 2015 Nov 25.

All asparagine-linked glycans (N-glycans) on the eukaryotic glycoproteins are primarily derived from dolichol-linked oligosaccharides (DLO), synthesized on the rough endoplasmic reticulum membrane. We have previously reported cloning and identification of the human gene, HMT-1, which encodes chitobiosyldiphosphodolichol beta-mannosyltransferase (β1,4-MT)...

Affinity chromatography of a lectin from Robinia pseudoacacia L. and demonstration of lectins in sieve-tube sap from other tree species.

Planta

Gietl C, Kauss H, Ziegler H.
PMID: 24407326
Planta. 1979 Jan;144(4):367-71. doi: 10.1007/BF00391580.

A carbohydrate-binding protein in the sievetube sap of Robinia pseudoacacia L. was isolated by affinity chromatography on D-galactosamine coupled to CH-Sepharose 4B. The yield of the purified protein was 41,3 μg/ml of sieve-tube sap or 5,7% of the total...

Serum Sclerostin Levels in Patients with Human Immunodeficiency Virus Infection and Their Association with Bone Turnover Markers and Bone Mineral Densitometry.

Journal of bone metabolism

Almansouri AY, Abdulfatah ME, Baaqil OH, Bakheet AA, Turki SA, Kotb MM, Althubaiti A, Almaghrabi MM, Althubaiti AM, Madani BM, Jawad AS.
PMID: 26981516
J Bone Metab. 2016 Feb;23(1):16-22. doi: 10.11005/jbm.2016.23.1.16. Epub 2016 Feb 29.

BACKGROUND: The aim of the study was to compare serum sclerostin levels in human im-munodeficiency virus (HIV)-infected patients and healthy controls, and to evaluate their relationship with bone turnover markers (BTM) and bone mineral density (BMD).METHODS: We prospectively studied...

Cell entry mechanisms of HSV: what we have learned in recent years.

Future virology

Agelidis AM, Shukla D.
PMID: 27066105
Future Virol. 2015 Oct 01;10(10):1145-1154. doi: 10.2217/fvl.15.85.

HSV type-1 and -2 are widespread pathogens producing lifelong infection with multiple sequelae, including oral, ocular and genital disease. The process of herpesvirus entry is a highly complex process involving numerous viral and cellular factors. Entry begins with attachment...

Isoprenoid pathway dysfunction in chronic fatigue syndrome.

Acta neuropsychiatrica

Kurup RK, Kurup PA.
PMID: 26983655
Acta Neuropsychiatr. 2003 Oct;15(5):266-73. doi: 10.1034/j.1601-5215.2003.00045.x.

BACKGROUND AND AIMS: The isoprenoid pathway was assessed in 15 patients with chronic fatigue syndrome (CFS). The pathway was also assessed in individuals with differing hemispheric dominance to assess whether hemispheric dominance has any correlation with these disease states.METHODS:...

Synthetic lectin arrays for the detection and discrimination of cancer associated glycans and cell lines.

Chemical science

Bicker KL, Sun J, Harrell M, Zhang Y, Pena MM, Thompson PR, Lavigne JJ.
PMID: 29051806
Chem Sci. 2012 Apr 01;3(4):1147-1156. doi: 10.1039/c2sc00790h. Epub 2012 Jan 05.

Aberrant glycosylation is a hallmark of various disease states, including cancer, and effective detection and discrimination between healthy and diseased cells is an important challenge for the diagnosis and treatment of many diseases. Here, we describe the use of...

Force Sensitivity in Saccharomyces cerevisiae Flocculins.

mSphere

Chan CX, El-Kirat-Chatel S, Joseph IG, Jackson DN, Ramsook CB, Dufrêne YF, Lipke PN.
PMID: 27547825
mSphere. 2016 Aug 17;1(4). doi: 10.1128/mSphere.00128-16. eCollection 2016.

Many fungal adhesins have short, β-aggregation-prone sequences that play important functional roles, and in the Candida albicans adhesin Als5p, these sequences cluster the adhesins after exposure to shear force. Here, we report that Saccharomyces cerevisiae flocculins Flo11p and Flo1p...

Varicella-Zoster Virus Glycoproteins: Entry, Replication, and Pathogenesis.

Current clinical microbiology reports

Oliver SL, Yang E, Arvin AM.
PMID: 28367398
Curr Clin Microbiol Rep. 2016 Dec;3(4):204-215. doi: 10.1007/s40588-016-0044-4. Epub 2016 Sep 09.

Varicella-zoster virus (VZV), an alphaherpesvirus that causes chicken pox (varicella) and shingles (herpes zoster), is a medically important pathogen that causes considerable morbidity and, on occasion, mortality in immunocompromised patients. Herpes zoster can afflict the elderly with a debilitating...

Downregulation of coding transmembrane protein 35 gene inhibits cell proliferation, migration and cell cycle arrest in osteosarcoma cells.

Experimental and therapeutic medicine

Huang Y, Zhao S, Zhang Y, Zhang C, Li X.
PMID: 27446247
Exp Ther Med. 2016 Aug;12(2):581-588. doi: 10.3892/etm.2016.3381. Epub 2016 May 23.

Osteosarcoma (OSA) is the most common primary tumor of the bone. Resistance to chemotherapy and the fast rapid development of metastatic lesions are major issues responsible for treatment failure and poor survival rates in OSA patients. Tetraspanins comprise a...

Pathogenesis of Idiopathic Myelofibrosis: A Review.

Hematology (Amsterdam, Netherlands)

Reilly JT.
PMID: 27416529
Hematology. 1998;3(3):205-13. doi: 10.1080/10245332.1998.11746392.

During the last two decades, important progress has been made in the understanding of the nature and pathogenesis of idiopathic myelofibrosis. The characteristic extracellular matrix is composed of a variety of interstitial and basement membrane glycoproteins, including collagen types...

Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK.

Endocrinology and metabolism (Seoul, Korea)

Lee J, Hong SW, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY.
PMID: 26194078
Endocrinol Metab (Seoul). 2015 Jun;30(2):177-84. doi: 10.3803/EnM.2015.30.2.177. Epub 2014 Jul 02.

BACKGROUND: Selenoprotein P (SEPP1) and fetuin-A, both circulating liver-derived glycoproteins, are novel biomarkers for insulin resistance and nonalcoholic fatty liver disease. However, the effect of exendin-4 (Ex-4), a glucagon-like peptide-1 receptor agonist, on the expression of hepatokines, SEPP1, and...

Showing 25 to 36 of 2544 entries