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Showing 25 to 36 of 4157 entries
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Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells.

Oncology letters

Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, Yang Z, Cao R, Tao H, Wang X, Zhou J.
PMID: 26870186
Oncol Lett. 2016 Jan;11(1):182-188. doi: 10.3892/ol.2015.3854. Epub 2015 Nov 02.

The present study investigated the anti-tumor activity of N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. TRPM8 expression in DU145 and normal prostate...

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Liu T, Fang Z, Wang G, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2015;11(1):182-188doi: 10.3892/ol.2015.3854.
Liu, T., Fang, Z., Wang, G., Shi, M., Wang, X., Jiang, K., Yang, Z., Cao, R., Tao, H., Wang, X., & Zhou, J. (2016). Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncology letters, 11(1), 182-188. https://doi.org/10.3892/ol.2015.3854
Liu, Tao, et al. "Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells." Oncology letters vol. 11,1 (2016): 182-188. doi: https://doi.org/10.3892/ol.2015.3854
Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, Yang Z, Cao R, Tao H, Wang X, Zhou J. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016 Jan;11(1):182-188. doi: 10.3892/ol.2015.3854. Epub 2015 Nov 02. PMID: 26870186; PMCID: PMC4727066.
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Present status of clinical deployment of glucokinase activators.

Journal of diabetes investigation

Nakamura A, Terauchi Y.
PMID: 25802718
J Diabetes Investig. 2015 Mar;6(2):124-32. doi: 10.1111/jdi.12294. Epub 2014 Nov 10.

Glucokinase is one of four members of the hexokinase family of enzymes. Its expression is limited to the major organs (such as the pancreas, liver, brain and the gastrointestinal tract) that are thought to have an integrated role in...

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Nakamura A, Terauchi Y. Present status of clinical deployment of glucokinase activators. J Diabetes Investig. 2014;6(2):124-32doi: 10.1111/jdi.12294.
Nakamura, A., & Terauchi, Y. (2015). Present status of clinical deployment of glucokinase activators. Journal of diabetes investigation, 6(2), 124-32. https://doi.org/10.1111/jdi.12294
Nakamura, Akinobu, and Terauchi, Yasuo. "Present status of clinical deployment of glucokinase activators." Journal of diabetes investigation vol. 6,2 (2015): 124-32. doi: https://doi.org/10.1111/jdi.12294
Nakamura A, Terauchi Y. Present status of clinical deployment of glucokinase activators. J Diabetes Investig. 2015 Mar;6(2):124-32. doi: 10.1111/jdi.12294. Epub 2014 Nov 10. PMID: 25802718; PMCID: PMC4364845.
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Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca(2+)]i Regulation, Glycogenolysis, Glutamate Synthesis, and K(+) Homeostasis are Similar but Not Identical in Learning and Mood Regulation.

Frontiers in integrative neuroscience

Chen Y, Du T, Peng L, Gibbs ME, Hertz L.
PMID: 26778984
Front Integr Neurosci. 2016 Jan 08;9:67. doi: 10.3389/fnint.2015.00067. eCollection 2015.

No abstract available.

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Chen Y, Du T, Peng L, et al. Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca(2+)]i Regulation, Glycogenolysis, Glutamate Synthesis, and K(+) Homeostasis are Similar but Not Identical in Learning and Mood Regulation. Front Integr Neurosci. 2016;9:67doi: 10.3389/fnint.2015.00067.
Chen, Y., Du, T., Peng, L., Gibbs, M. E., & Hertz, L. (2015). Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca(2+)]i Regulation, Glycogenolysis, Glutamate Synthesis, and K(+) Homeostasis are Similar but Not Identical in Learning and Mood Regulation. Frontiers in integrative neuroscience, 967. https://doi.org/10.3389/fnint.2015.00067
Chen, Ye, et al. "Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca(2+)]i Regulation, Glycogenolysis, Glutamate Synthesis, and K(+) Homeostasis are Similar but Not Identical in Learning and Mood Regulation." Frontiers in integrative neuroscience vol. 9 (2015): 67. doi: https://doi.org/10.3389/fnint.2015.00067
Chen Y, Du T, Peng L, Gibbs ME, Hertz L. Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca(2+)]i Regulation, Glycogenolysis, Glutamate Synthesis, and K(+) Homeostasis are Similar but Not Identical in Learning and Mood Regulation. Front Integr Neurosci. 2016 Jan 08;9:67. doi: 10.3389/fnint.2015.00067. eCollection 2015. PMID: 26778984; PMCID: PMC4705236.
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Development and characterization of a new human hepatic cell line.

EXCLI journal

Ramboer E, De Craene B, De Kock J, Berx G, Rogiers V, Vanhaecke T, Vinken M.
PMID: 26869867
EXCLI J. 2015 Jul 28;14:875-89. doi: 10.17179/excli2015-424. eCollection 2015.

The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines. The aim of this study was to develop a human hepatic...

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Ramboer E, De Craene B, De Kock J, et al. Development and characterization of a new human hepatic cell line. EXCLI J. 2015;14:875-89doi: 10.17179/excli2015-424.
Ramboer, E., De Craene, B., De Kock, J., Berx, G., Rogiers, V., Vanhaecke, T., & Vinken, M. (2015). Development and characterization of a new human hepatic cell line. EXCLI journal, 14875-89. https://doi.org/10.17179/excli2015-424
Ramboer, Eva, et al. "Development and characterization of a new human hepatic cell line." EXCLI journal vol. 14 (2015): 875-89. doi: https://doi.org/10.17179/excli2015-424
Ramboer E, De Craene B, De Kock J, Berx G, Rogiers V, Vanhaecke T, Vinken M. Development and characterization of a new human hepatic cell line. EXCLI J. 2015 Jul 28;14:875-89. doi: 10.17179/excli2015-424. eCollection 2015. PMID: 26869867; PMCID: PMC4747020.
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Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver.

World journal of hepatology

Schneider AC, Gregório C, Uribe-Cruz C, Guizzo R, Malysz T, Faccioni-Heuser MC, Longo L, da Silveira TR.
PMID: 28357029
World J Hepatol. 2017 Mar 18;9(8):418-426. doi: 10.4254/wjh.v9.i8.418.

AIM: To evaluate the effects of chronic exposure to ethanol in the liver and the expression of inflammatory genes in zebrafish.METHODS: Zebrafish (RESULTS: Exposing zebrafish to 0.5% ethanol developed intense liver steatosis after four weeks, as demonstrated by oil...

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Schneider AC, Gregório C, Uribe-Cruz C, et al. Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver. World J Hepatol. 2017;9(8):418-426doi: 10.4254/wjh.v9.i8.418.
Schneider, A. C., Gregório, C., Uribe-Cruz, C., Guizzo, R., Malysz, T., Faccioni-Heuser, M. C., Longo, L., & da Silveira, T. R. (2017). Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver. World journal of hepatology, 9(8), 418-426. https://doi.org/10.4254/wjh.v9.i8.418
Schneider, Ana Claudia Reis, et al. "Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver." World journal of hepatology vol. 9,8 (2017): 418-426. doi: https://doi.org/10.4254/wjh.v9.i8.418
Schneider AC, Gregório C, Uribe-Cruz C, Guizzo R, Malysz T, Faccioni-Heuser MC, Longo L, da Silveira TR. Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver. World J Hepatol. 2017 Mar 18;9(8):418-426. doi: 10.4254/wjh.v9.i8.418. PMID: 28357029; PMCID: PMC5355764.
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Pharmacological Enhancement of Mutated α-Glucosidase Activity in Fibroblasts from Patients with Pompe Disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Parenti G, Zuppaldi A, Gabriela Pittis M, Rosaria Tuzzi M, Annunziata I, Meroni G, Porto C, Donaudy F, Rossi B, Rossi M, Filocamo M, Donati A, Bembi B, Ballabio A, Andria G.
PMID: 28182897
Mol Ther. 2007 Mar;15(3):508-514. doi: 10.1038/sj.mt.6300074. Epub 2016 Dec 08.

We investigated the use of pharmacological chaperones for the therapy of Pompe disease, a metabolic myopathy due to mutations of the gene encoding the lysosomal hydrolase α-glucosidase (GAA) and characterized by generalized glycogen storage in cardiac and skeletal muscle....

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Parenti G, Zuppaldi A, Gabriela Pittis M, et al. Pharmacological Enhancement of Mutated α-Glucosidase Activity in Fibroblasts from Patients with Pompe Disease. Mol Ther. 2016;15(3):508-514doi: 10.1038/sj.mt.6300074.
Parenti, G., Zuppaldi, A., Gabriela Pittis, M., Rosaria Tuzzi, M., Annunziata, I., Meroni, G., Porto, C., Donaudy, F., Rossi, B., Rossi, M., Filocamo, M., Donati, A., Bembi, B., Ballabio, A., & Andria, G. (2007). Pharmacological Enhancement of Mutated α-Glucosidase Activity in Fibroblasts from Patients with Pompe Disease. Molecular therapy : the journal of the American Society of Gene Therapy, 15(3), 508-514. https://doi.org/10.1038/sj.mt.6300074
Parenti, Giancarlo, et al. "Pharmacological Enhancement of Mutated α-Glucosidase Activity in Fibroblasts from Patients with Pompe Disease." Molecular therapy : the journal of the American Society of Gene Therapy vol. 15,3 (2007): 508-514. doi: https://doi.org/10.1038/sj.mt.6300074
Parenti G, Zuppaldi A, Gabriela Pittis M, Rosaria Tuzzi M, Annunziata I, Meroni G, Porto C, Donaudy F, Rossi B, Rossi M, Filocamo M, Donati A, Bembi B, Ballabio A, Andria G. Pharmacological Enhancement of Mutated α-Glucosidase Activity in Fibroblasts from Patients with Pompe Disease. Mol Ther. 2007 Mar;15(3):508-514. doi: 10.1038/sj.mt.6300074. Epub 2016 Dec 08. PMID: 28182897.
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Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer.

Experimental and therapeutic medicine

Wu F, Chen J, Fan LM, Liu K, Zhang N, Li SW, Zhu H, Gao HC.
PMID: 28672902
Exp Ther Med. 2017 Jul;14(1):127-130. doi: 10.3892/etm.2017.4494. Epub 2017 May 22.

The aim of the present study was to investigate the effect of rutin treatment on the expression of glycogen synthase kinase (GSK)-3β and tumor necrosis factor (TNF)-α in A549 human lung carcinoma cells. The A549 cells were divided into...

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Wu F, Chen J, Fan LM, et al. Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer. Exp Ther Med. 2017;14(1):127-130doi: 10.3892/etm.2017.4494.
Wu, F., Chen, J., Fan, L. M., Liu, K., Zhang, N., Li, S. W., Zhu, H., & Gao, H. C. (2017). Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer. Experimental and therapeutic medicine, 14(1), 127-130. https://doi.org/10.3892/etm.2017.4494
Wu, Fei, et al. "Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer." Experimental and therapeutic medicine vol. 14,1 (2017): 127-130. doi: https://doi.org/10.3892/etm.2017.4494
Wu F, Chen J, Fan LM, Liu K, Zhang N, Li SW, Zhu H, Gao HC. Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer. Exp Ther Med. 2017 Jul;14(1):127-130. doi: 10.3892/etm.2017.4494. Epub 2017 May 22. PMID: 28672902; PMCID: PMC5488604.
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Physicochemical Characteristics of Rat Muscle Glycogen Fractions.

Journal of clinical and diagnostic research : JCDR

Ghafouri Z, Rasouli M.
PMID: 28571127
J Clin Diagn Res. 2017 Apr;11(4):BC05-BC08. doi: 10.7860/JCDR/2017/24566.9618. Epub 2017 Apr 01.

INTRODUCTION: Homogenization of animal tissues with cold Perchloric Acid (PCA) produces two fractions of glycogen, Acid Soluble Glycogen (ASG) and Acid Insoluble Glycogen (AIG).AIM: To determine some physicochemical characteristics of muscle glycogen fractions in two groups of rat.MATERIALS AND...

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Ghafouri Z, Rasouli M. Physicochemical Characteristics of Rat Muscle Glycogen Fractions. J Clin Diagn Res. 2017;11(4):BC05-BC08doi: 10.7860/JCDR/2017/24566.9618.
Ghafouri, Z., & Rasouli, M. (2017). Physicochemical Characteristics of Rat Muscle Glycogen Fractions. Journal of clinical and diagnostic research : JCDR, 11(4), BC05-BC08. https://doi.org/10.7860/JCDR/2017/24566.9618
Ghafouri, Zahra, and Rasouli, Mehdi. "Physicochemical Characteristics of Rat Muscle Glycogen Fractions." Journal of clinical and diagnostic research : JCDR vol. 11,4 (2017): BC05-BC08. doi: https://doi.org/10.7860/JCDR/2017/24566.9618
Ghafouri Z, Rasouli M. Physicochemical Characteristics of Rat Muscle Glycogen Fractions. J Clin Diagn Res. 2017 Apr;11(4):BC05-BC08. doi: 10.7860/JCDR/2017/24566.9618. Epub 2017 Apr 01. PMID: 28571127; PMCID: PMC5449773.
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Acute Pancreatitis Secondary to Severe Hypertriglyceridaemia in a Patient with Type 1a Glycogen Storage Disease: Emergent Use of Plasmapheresis.

JIMD reports

Rivers E, Reynolds BC, Bunn S, Leech NJ, Straker J, Lambert HJ.
PMID: 29030854
JIMD Rep. 2018;42:1-4. doi: 10.1007/8904_2017_64. Epub 2017 Oct 14.

Acute pancreatitis is a well-recognised complication of hypertriglyceridaemia. High serum triglycerides may develop in the autosomal recessive disorder glycogen storage disease (GSD). Plasmapheresis has been effective in reducing triglyceride levels in pancreatitis secondary to other conditions but not previously...

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Rivers E, Reynolds BC, Bunn S, et al. Acute Pancreatitis Secondary to Severe Hypertriglyceridaemia in a Patient with Type 1a Glycogen Storage Disease: Emergent Use of Plasmapheresis. JIMD Rep. 2017;42:1-4doi: 10.1007/8904_2017_64.
Rivers, E., Reynolds, B. C., Bunn, S., Leech, N. J., Straker, J., & Lambert, H. J. (2018). Acute Pancreatitis Secondary to Severe Hypertriglyceridaemia in a Patient with Type 1a Glycogen Storage Disease: Emergent Use of Plasmapheresis. JIMD reports, 421-4. https://doi.org/10.1007/8904_2017_64
Rivers, E, et al. "Acute Pancreatitis Secondary to Severe Hypertriglyceridaemia in a Patient with Type 1a Glycogen Storage Disease: Emergent Use of Plasmapheresis." JIMD reports vol. 42 (2018): 1-4. doi: https://doi.org/10.1007/8904_2017_64
Rivers E, Reynolds BC, Bunn S, Leech NJ, Straker J, Lambert HJ. Acute Pancreatitis Secondary to Severe Hypertriglyceridaemia in a Patient with Type 1a Glycogen Storage Disease: Emergent Use of Plasmapheresis. JIMD Rep. 2018;42:1-4. doi: 10.1007/8904_2017_64. Epub 2017 Oct 14. PMID: 29030854; PMCID: PMC6226393.
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A case report of congenital glycogen storage liver cirrhosis treated with bone marrow derived stem cells.

Stem cell investigation

Wehbe TW, Abi Chahine NH, Annous AA, Ferri MA, Boulous RC, El-Mestrah MF.
PMID: 29057245
Stem Cell Investig. 2017 Sep 07;4:73. doi: 10.21037/sci.2017.07.04. eCollection 2017.

Liver cirrhosis represents a state of end-stage failure that is usually fatal. The condition results in liver dysfunction, recurrent ascites, encephalopathy, renal failure, splenomegaly, bleeding, and a poor quality of life in general. With the current severe shortage of...

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Wehbe TW, Abi Chahine NH, Annous AA, et al. A case report of congenital glycogen storage liver cirrhosis treated with bone marrow derived stem cells. Stem Cell Investig. 2017;4:73doi: 10.21037/sci.2017.07.04.
Wehbe, T. W., Abi Chahine, N. H., Annous, A. A., Ferri, M. A., Boulous, R. C., & El-Mestrah, M. F. (2017). A case report of congenital glycogen storage liver cirrhosis treated with bone marrow derived stem cells. Stem cell investigation, 473. https://doi.org/10.21037/sci.2017.07.04
Wehbe, Terek W, et al. "A case report of congenital glycogen storage liver cirrhosis treated with bone marrow derived stem cells." Stem cell investigation vol. 4 (2017): 73. doi: https://doi.org/10.21037/sci.2017.07.04
Wehbe TW, Abi Chahine NH, Annous AA, Ferri MA, Boulous RC, El-Mestrah MF. A case report of congenital glycogen storage liver cirrhosis treated with bone marrow derived stem cells. Stem Cell Investig. 2017 Sep 07;4:73. doi: 10.21037/sci.2017.07.04. eCollection 2017. PMID: 29057245; PMCID: PMC5638994.
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MPV in Uncontrolled & Controlled Diabetics- Its Role as an Indicator of Vascular Complication.

Journal of clinical and diagnostic research : JCDR

Radha RK, Selvam D.
PMID: 27656448
J Clin Diagn Res. 2016 Aug;10(8):EC22-6. doi: 10.7860/JCDR/2016/21499.8353. Epub 2016 Aug 01.

INTRODUCTION: Platelets are tiny, disc-shaped, non-nucleated structures derived from megakaryocytes. The morphological differences in measuring Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) of platelets have important implications for assessing the functional expressions of platelets. Electron microscopy reveals...

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Radha RK, Selvam D. MPV in Uncontrolled & Controlled Diabetics- Its Role as an Indicator of Vascular Complication. J Clin Diagn Res. 2016;10(8):EC22-6doi: 10.7860/JCDR/2016/21499.8353.
Radha, R. K., & Selvam, D. (2016). MPV in Uncontrolled & Controlled Diabetics- Its Role as an Indicator of Vascular Complication. Journal of clinical and diagnostic research : JCDR, 10(8), EC22-6. https://doi.org/10.7860/JCDR/2016/21499.8353
Radha, Rajesh Kanna Nandagopal, and Selvam, Diwakar. "MPV in Uncontrolled & Controlled Diabetics- Its Role as an Indicator of Vascular Complication." Journal of clinical and diagnostic research : JCDR vol. 10,8 (2016): EC22-6. doi: https://doi.org/10.7860/JCDR/2016/21499.8353
Radha RK, Selvam D. MPV in Uncontrolled & Controlled Diabetics- Its Role as an Indicator of Vascular Complication. J Clin Diagn Res. 2016 Aug;10(8):EC22-6. doi: 10.7860/JCDR/2016/21499.8353. Epub 2016 Aug 01. PMID: 27656448; PMCID: PMC5028587.
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IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways.

International journal of clinical and experimental medicine

Xie Q, Sun Z, Chen M, Zhong Q, Yang T, Yi J.
PMID: 26550160
Int J Clin Exp Med. 2015 Aug 15;8(8):12498-508. eCollection 2015.

BACKGROUND: Therapeutic myocardial angiogenesis is an important compensatory mechanism in severely coronary stenosis. Previous studies demonstrated that interleukin-8 (IL-8) not only plays an important role in inflammation, but also a potent angiogenic factor through p38 mitogen-activated protein kinase (p38MAPK),...

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Xie Q, Sun Z, Chen M, et al. IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways. Int J Clin Exp Med. 2015;8(8):12498-508
Xie, Q., Sun, Z., Chen, M., Zhong, Q., Yang, T., & Yi, J. (2015). IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways. International journal of clinical and experimental medicine, 8(8), 12498-508.
Xie, Qiying, et al. "IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways." International journal of clinical and experimental medicine vol. 8,8 (2015): 12498-508.
Xie Q, Sun Z, Chen M, Zhong Q, Yang T, Yi J. IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways. Int J Clin Exp Med. 2015 Aug 15;8(8):12498-508. eCollection 2015. PMID: 26550160; PMCID: PMC4612845.
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Showing 25 to 36 of 4157 entries