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Showing 25 to 36 of 122 entries
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Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia.

Clinical pharmacology and therapeutics

Hee Nam Y, Brensinger CM, Bilker WB, Flory JH, Leonard CE, Hennessy S.
PMID: 34312836
Clin Pharmacol Ther. 2021 Jul 27; doi: 10.1002/cpt.2377. Epub 2021 Jul 27.

Serious hypoglycemia is a major adverse event associated with insulin secretagogues. Previous studies have suggested a potential relationship between angiotensin-converting enzyme inhibitors (ACEIs) used with sulfonylureas and serious hypoglycemia, and widely used drug compendia warn of this potential drug-drug...

Use of oral anti-diabetic agents in pregnancy: a pragmatic approach.

North American journal of medical sciences

Kalra B, Gupta Y, Singla R, Kalra S.
PMID: 25709972
N Am J Med Sci. 2015 Jan;7(1):6-12. doi: 10.4103/1947-2714.150081.

Insulin is the gold standard for treatment of hyperglycemia during pregnancy, when lifestyle measures do not maintain glycemic control during pregnancy. However, recent studies have suggested that certain oral hypoglycemic agents (metformin and glyburide) may be safe and be...

Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia.

Clinical pharmacology and therapeutics

Hee Nam Y, Brensinger CM, Bilker WB, Flory JH, Leonard CE, Hennessy S.
PMID: 34312836
Clin Pharmacol Ther. 2022 Jan;111(1):218-226. doi: 10.1002/cpt.2377. Epub 2021 Aug 23.

Serious hypoglycemia is a major adverse event associated with insulin secretagogues. Previous studies have suggested a potential relationship between angiotensin-converting enzyme inhibitors (ACEIs) used with sulfonylureas and serious hypoglycemia, and widely used drug compendia warn of this potential drug-drug...

Refocusing on public policy--in step with member value.

Journal of the American Dietetic Association

Glibride J, Samour P, Hill L, Pavlinac J.
PMID: 12487535
J Am Diet Assoc. 2002 Dec;102(12):1752-3. doi: 10.1016/s0002-8223(02)90376-7.

No abstract available.

Pinacidil's Effects on Defibrillation Outcomes: Role of Increased Potassium Conductance Via the K(ATP) Channel.

Journal of cardiovascular pharmacology and therapeutics

Winecoff AP, Sims JJ, Markel ML, Ujhelyi MR.
PMID: 10684456
J Cardiovasc Pharmacol Ther. 1997 Jul;2(3):171-180. doi: 10.1177/107424849700200304.

BACKGROUND: It has been shown that the inhibition of potassium ion conductance decreases defibrillation threshold. We postulated that if potassium conductance is a primary mechanism affecting defibrillation threshold values, then increasing potassium ion conductance will increase defibrillation values. The...

Clinical trials with glimepiride.

Drugs of today (Barcelona, Spain : 1998)

Clark CM, Helmy AW.
PMID: 15010703
Drugs Today (Barc). 1998 May;34(5):401-8. doi: 10.1358/dot.1998.34.5.472186.

Data from 21 placebo-controlled, active-controlled or noncomparative studies involving more than 6500 patients, more than 4220 of whom were treated with glimepiride, are reviewed. Glimepiride has a rapid onset of action and is effective at a single daily dose....

Role of Various Potassium Channels in Caffeine-induced Aortic Relaxation in Rats.

Saudi journal of medicine & medical sciences

Latif R, Badar A.
PMID: 30787729
Saudi J Med Med Sci. 2016 Sep-Dec;4(3):197-201. doi: 10.4103/1658-631X.188251. Epub 2016 Aug 11.

BACKGROUND: Studies done on caffeine-induced changes in aortic rings have demonstrated inconclusive results. Moreover, the role of various potassium channels in caffeine-induced effects has not been explored so far. The present MATERIALS AND METHODS: This study was carried out...

Increased fracture risk in patients treated with thiazolidinediones: the role of abnormal bone turnover.

Expert review of endocrinology & metabolism

Cooper M.
PMID: 30764043
Expert Rev Endocrinol Metab. 2010 Mar;5(2):177-180. doi: 10.1586/eem.10.4.

Evaluation of: Zinman B, Haffner SM, Herman WH et al. Effect of rosiglitazone, metformin, and glyburide on bone biomarkers in patients with Type 2 diabetes. J. Clin. Endocrinol. Metab. 95(1), 134-142 (2010). Until recently, patients with Type 2 diabetes...

Improved glycemic control with use of oral hypoglycemic therapy with or without insulin.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Bell DS, Mayo MS.
PMID: 15251750
Endocr Pract. 1998 Mar-Apr;4(2):82-5. doi: 10.4158/EP.4.2.82.

OBJECTIVE: To determine whether combination oral hypoglycemic therapy in insulin-using patients with non-insulin-dependent diabetes mellitus (NIDDM) can improve glycemic control for a prolonged period.METHODS: We expanded and extended an earlier study to include 130 patients with NIDDM for 10...

Spontaneous hypoglycemia associated with congestive heart failure attributable to hyperinsulinism.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Khoury H, Daugherty T, Ehsanipoor K.
PMID: 15251753
Endocr Pract. 1998 Mar-Apr;4(2):94-5. doi: 10.4158/EP.4.2.94.

OBJECTIVE: To report a case of spontaneous hypoglycemia associated with congestive heart failure in an adult.METHODS: We describe a 72-year-old man in whom profound hypoglycemia (serum glucose level, 21 mg/dL) developed during an exacerbation of heart failure. Clinical and...

New therapeutic approaches to non-insulin-dependent diabetes mellitus.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Bloomgarden ZT.
PMID: 15251787
Endocr Pract. 1997 Sep-Oct;3(5):307-12. doi: 10.4158/EP.3.5.307.

OBJECTIVE: To review the new treatment strategies for non-insulin-dependent diabetes mellitus (NIDDM).METHODS: Various measures aimed at either increasing insulin secretion or decreasing insulin resistance are outlined. In addition, the management of obesity in patients with diabetes is discussed.RESULTS: Two...

Alogliptin: a new addition to the class of DPP-4 inhibitors.

Diabetes, metabolic syndrome and obesity : targets and therapy

Andukuri R, Drincic A, Rendell M.
PMID: 21437125
Diabetes Metab Syndr Obes. 2009 Jul 21;2:117-26.

BACKGROUND: Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Inhibition of DPP-4 elevates levels of the incretin hormones glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) by preventing their degradation.OBJECTIVE:...

Showing 25 to 36 of 122 entries