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Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway.

International journal of biological macromolecules

Zha Z, Liu Y, Miao Y, Liao S, Wang SY, Tang H, Yin H.
PMID: 34998873
Int J Biol Macromol. 2022 Jan 05; doi: 10.1016/j.ijbiomac.2021.12.098. Epub 2022 Jan 05.

Heparosan, with a linear chain of disaccharide repeating units of →4) β-D-glucuronic acid (GlcA) (1→4)-α-D-N-acetylglucosamine (GlcNAc) (1→, is a potential starting chemical for heparin synthesis. However, the chemoenzymatic synthesis of single-site sulfated heparosan and its antitumor activity have not...

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Zha Z, Liu Y, Miao Y, et al. Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway. Int J Biol Macromol. 2022;doi: 10.1016/j.ijbiomac.2021.12.098.
Zha, Z., Liu, Y., Miao, Y., Liao, S., Wang, S. Y., Tang, H., & Yin, H. (2022). Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway. International journal of biological macromolecules, . https://doi.org/10.1016/j.ijbiomac.2021.12.098
Zha, Zhengqi, et al. "Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway." International journal of biological macromolecules vol. (2022). doi: https://doi.org/10.1016/j.ijbiomac.2021.12.098
Zha Z, Liu Y, Miao Y, Liao S, Wang SY, Tang H, Yin H. Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway. Int J Biol Macromol. 2022 Jan 05; doi: 10.1016/j.ijbiomac.2021.12.098. Epub 2022 Jan 05. PMID: 34998873.
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Glucose-Responsive Multifunctional Metal-Organic Drug-Loaded Hydrogel for Diabetic Wound Healing.

Acta biomaterialia

Yang J, Zeng W, Xu P, Fu X, Yu X, Chen L, Leng F, Yu C, Yang Z.
PMID: 34879294
Acta Biomater. 2021 Dec 05; doi: 10.1016/j.actbio.2021.11.043. Epub 2021 Dec 05.

As the incidence of diabetes increases, its complication, diabetic foot ulcers, has become the main type of clinically chronic refractory wounds. Due to the hyperglycemic microenvironment of the diabetic wound, which leads to vascular defects and bacterial growth, the...

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Yang J, Zeng W, Xu P, et al. Glucose-Responsive Multifunctional Metal-Organic Drug-Loaded Hydrogel for Diabetic Wound Healing. Acta Biomater. 2021;doi: 10.1016/j.actbio.2021.11.043.
Yang, J., Zeng, W., Xu, P., Fu, X., Yu, X., Chen, L., Leng, F., Yu, C., & Yang, Z. (2021). Glucose-Responsive Multifunctional Metal-Organic Drug-Loaded Hydrogel for Diabetic Wound Healing. Acta biomaterialia, . https://doi.org/10.1016/j.actbio.2021.11.043
Yang, Jiaxin, et al. "Glucose-Responsive Multifunctional Metal-Organic Drug-Loaded Hydrogel for Diabetic Wound Healing." Acta biomaterialia vol. (2021). doi: https://doi.org/10.1016/j.actbio.2021.11.043
Yang J, Zeng W, Xu P, Fu X, Yu X, Chen L, Leng F, Yu C, Yang Z. Glucose-Responsive Multifunctional Metal-Organic Drug-Loaded Hydrogel for Diabetic Wound Healing. Acta Biomater. 2021 Dec 05; doi: 10.1016/j.actbio.2021.11.043. Epub 2021 Dec 05. PMID: 34879294.
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Discovery of a Novel Glucuronan Lyase System in .

Applied and environmental microbiology

Pilgaard B, Vuillemin M, Munk L, Holck J, Meier S, Wilkens C, Meyer AS.
PMID: 34705548
Appl Environ Microbiol. 2022 Jan 11;88(1):e0181921. doi: 10.1128/AEM.01819-21. Epub 2021 Oct 27.

Glucuronan lyases (EC 4.2.2.14) catalyze depolymerization of linear β-(1,4)-polyglucuronic acid (glucuronan). Only a few glucuronan lyases have been characterized until now, most of them originating from bacteria. Here we report the discovery, recombinant production, and functional characterization of the...

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Pilgaard B, Vuillemin M, Munk L, et al. Discovery of a Novel Glucuronan Lyase System in . Appl Environ Microbiol. 2021;88(1):e0181921doi: 10.1128/AEM.01819-21.
Pilgaard, B., Vuillemin, M., Munk, L., Holck, J., Meier, S., Wilkens, C., & Meyer, A. S. (2022). Discovery of a Novel Glucuronan Lyase System in . Applied and environmental microbiology, 88(1), e0181921. https://doi.org/10.1128/AEM.01819-21
Pilgaard, Bo, et al. "Discovery of a Novel Glucuronan Lyase System in ." Applied and environmental microbiology vol. 88,1 (2022): e0181921. doi: https://doi.org/10.1128/AEM.01819-21
Pilgaard B, Vuillemin M, Munk L, Holck J, Meier S, Wilkens C, Meyer AS. Discovery of a Novel Glucuronan Lyase System in . Appl Environ Microbiol. 2022 Jan 11;88(1):e0181921. doi: 10.1128/AEM.01819-21. Epub 2021 Oct 27. PMID: 34705548.
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Domain Mapping of Chondroitin/Dermatan Sulfate Glycosaminoglycans Enables Structural Characterization of Proteoglycans.

Molecular & cellular proteomics : MCP

Persson A, Nikpour M, Vorontsov E, Nilsson J, Larson G.
PMID: 33757834
Mol Cell Proteomics. 2021 Mar 20;20:100074. doi: 10.1016/j.mcpro.2021.100074. Epub 2021 Mar 20.

Of all posttranslational modifications known, glycosaminoglycans (GAGs) remain one of the most challenging to study, and despite the recent years of advancement in MS technologies and bioinformatics, detailed knowledge about the complete structures of GAGs as part of proteoglycans...

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Persson A, Nikpour M, Vorontsov E, et al. Domain Mapping of Chondroitin/Dermatan Sulfate Glycosaminoglycans Enables Structural Characterization of Proteoglycans. Mol Cell Proteomics. 2021;20:100074doi: 10.1016/j.mcpro.2021.100074.
Persson, A., Nikpour, M., Vorontsov, E., Nilsson, J., & Larson, G. (2021). Domain Mapping of Chondroitin/Dermatan Sulfate Glycosaminoglycans Enables Structural Characterization of Proteoglycans. Molecular & cellular proteomics : MCP, 20100074. https://doi.org/10.1016/j.mcpro.2021.100074
Persson, Andrea, et al. "Domain Mapping of Chondroitin/Dermatan Sulfate Glycosaminoglycans Enables Structural Characterization of Proteoglycans." Molecular & cellular proteomics : MCP vol. 20 (2021): 100074. doi: https://doi.org/10.1016/j.mcpro.2021.100074
Persson A, Nikpour M, Vorontsov E, Nilsson J, Larson G. Domain Mapping of Chondroitin/Dermatan Sulfate Glycosaminoglycans Enables Structural Characterization of Proteoglycans. Mol Cell Proteomics. 2021 Mar 20;20:100074. doi: 10.1016/j.mcpro.2021.100074. Epub 2021 Mar 20. PMID: 33757834.
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Structural characterization of ulvans extracted from blade (Ulva ohnoi) and filamentous (Ulva tepida and Ulva prolifera) species of cultivated Ulva.

International journal of biological macromolecules

Glasson CRK, Luiten CA, Carnachan SM, Daines AM, Kidgell JT, Hinkley SFR, Praeger C, Andrade Martinez M, Sargison L, Magnusson M, de Nys R, Sims IM.
PMID: 34813787
Int J Biol Macromol. 2021 Nov 20; doi: 10.1016/j.ijbiomac.2021.11.100. Epub 2021 Nov 20.

Ulvans from Ulva ohnoi, Ulva tepida and Ulva prolifera were extracted under mild acidic conditions, isolated and their composition and structure determined. The ulvans contained mostly rhamnose (31.6-46.7 mol%) and glucuronic acid (26.6-37.5 mol%), with smaller amounts of xylose...

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Glasson CRK, Luiten CA, Carnachan SM, et al. Structural characterization of ulvans extracted from blade (Ulva ohnoi) and filamentous (Ulva tepida and Ulva prolifera) species of cultivated Ulva. Int J Biol Macromol. 2021;doi: 10.1016/j.ijbiomac.2021.11.100.
Glasson, C. R. K., Luiten, C. A., Carnachan, S. M., Daines, A. M., Kidgell, J. T., Hinkley, S. F. R., Praeger, C., Andrade Martinez, M., Sargison, L., Magnusson, M., de Nys, R., & Sims, I. M. (2021). Structural characterization of ulvans extracted from blade (Ulva ohnoi) and filamentous (Ulva tepida and Ulva prolifera) species of cultivated Ulva. International journal of biological macromolecules, . https://doi.org/10.1016/j.ijbiomac.2021.11.100
Glasson, Christopher R K, et al. "Structural characterization of ulvans extracted from blade (Ulva ohnoi) and filamentous (Ulva tepida and Ulva prolifera) species of cultivated Ulva." International journal of biological macromolecules vol. (2021). doi: https://doi.org/10.1016/j.ijbiomac.2021.11.100
Glasson CRK, Luiten CA, Carnachan SM, Daines AM, Kidgell JT, Hinkley SFR, Praeger C, Andrade Martinez M, Sargison L, Magnusson M, de Nys R, Sims IM. Structural characterization of ulvans extracted from blade (Ulva ohnoi) and filamentous (Ulva tepida and Ulva prolifera) species of cultivated Ulva. Int J Biol Macromol. 2021 Nov 20; doi: 10.1016/j.ijbiomac.2021.11.100. Epub 2021 Nov 20. PMID: 34813787.
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Metabolic profiling of HepG2 cells incubated with S(-) and R(+) enantiomers of anti-coagulating drug warfarin.

Metabolomics : Official journal of the Metabolomic Society

Bai J, Wang MX, Chowbay B, Ching CB, Chen WN.
PMID: 21949493
Metabolomics. 2011 Sep;7(3):353-362. doi: 10.1007/s11306-010-0262-3. Epub 2010 Nov 25.

Warfarin is a commonly prescribed oral anticoagulant with narrow therapeutic index. It achieves anti-coagulating effects by interfering with the vitamin K cycle. Warfarin has two enantiomers, S(-) and R(+) and undergoes stereoselective metabolism, with the S(-) enantiomer being more...

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Bai J, Wang MX, Chowbay B, et al. Metabolic profiling of HepG2 cells incubated with S(-) and R(+) enantiomers of anti-coagulating drug warfarin. Metabolomics. 2010;7(3):353-362doi: 10.1007/s11306-010-0262-3.
Bai, J., Wang, M. X., Chowbay, B., Ching, C. B., & Chen, W. N. (2011). Metabolic profiling of HepG2 cells incubated with S(-) and R(+) enantiomers of anti-coagulating drug warfarin. Metabolomics : Official journal of the Metabolomic Society, 7(3), 353-362. https://doi.org/10.1007/s11306-010-0262-3
Bai, Jing, et al. "Metabolic profiling of HepG2 cells incubated with S(-) and R(+) enantiomers of anti-coagulating drug warfarin." Metabolomics : Official journal of the Metabolomic Society vol. 7,3 (2011): 353-362. doi: https://doi.org/10.1007/s11306-010-0262-3
Bai J, Wang MX, Chowbay B, Ching CB, Chen WN. Metabolic profiling of HepG2 cells incubated with S(-) and R(+) enantiomers of anti-coagulating drug warfarin. Metabolomics. 2011 Sep;7(3):353-362. doi: 10.1007/s11306-010-0262-3. Epub 2010 Nov 25. PMID: 21949493; PMCID: PMC3155677.
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Chemical characterization of Tianshan green tea polysaccharides and its protective effects on cell oxidative injury.

Journal of food biochemistry

Liu J, Lin J, Huang Z, Zheng Q, Lin F, Wu L.
PMID: 34825388
J Food Biochem. 2022 Jan;46(1):e14000. doi: 10.1111/jfbc.14000. Epub 2021 Nov 25.

The purpose of this study was to analyze the chemical characterization of Tianshan green tea polysaccharides (TSPS), and evaluate its antioxidant activity by chemical-based and cellular-based antioxidant models in vitro. The results showed that the TSPS were composed of...

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Liu J, Lin J, Huang Z, et al. Chemical characterization of Tianshan green tea polysaccharides and its protective effects on cell oxidative injury. J Food Biochem. 2021;46(1):e14000doi: 10.1111/jfbc.14000.
Liu, J., Lin, J., Huang, Z., Zheng, Q., Lin, F., & Wu, L. (2022). Chemical characterization of Tianshan green tea polysaccharides and its protective effects on cell oxidative injury. Journal of food biochemistry, 46(1), e14000. https://doi.org/10.1111/jfbc.14000
Liu, Jianbing, et al. "Chemical characterization of Tianshan green tea polysaccharides and its protective effects on cell oxidative injury." Journal of food biochemistry vol. 46,1 (2022): e14000. doi: https://doi.org/10.1111/jfbc.14000
Liu J, Lin J, Huang Z, Zheng Q, Lin F, Wu L. Chemical characterization of Tianshan green tea polysaccharides and its protective effects on cell oxidative injury. J Food Biochem. 2022 Jan;46(1):e14000. doi: 10.1111/jfbc.14000. Epub 2021 Nov 25. PMID: 34825388.
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Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review.

Marine drugs

Sanjeewa KKA, Herath KHINM, Yang HW, Choi CS, Jeon YJ.
PMID: 34940677
Mar Drugs. 2021 Nov 28;19(12). doi: 10.3390/md19120678.

Fucoidans are sulfated heteropolysaccharides found in the cell walls of brown seaweeds (Phaeophyceae) and in some marine invertebrates. Generally, fucoidans are composed of significant amounts of L-fucose and sulfate groups, and lesser amounts of arabinose, galactose, glucose, glucuronic acid,...

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Sanjeewa KKA, Herath KHINM, Yang HW, et al. Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review. Mar Drugs. 2021;19(12)doi: 10.3390/md19120678.
Sanjeewa, K. K. A., Herath, K. H. I. N. M., Yang, H. W., Choi, C. S., & Jeon, Y. J. (2021). Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review. Marine drugs, 19(12), . https://doi.org/10.3390/md19120678
Sanjeewa, Kalu K Asanka, et al. "Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review." Marine drugs vol. 19,12 (2021). doi: https://doi.org/10.3390/md19120678
Sanjeewa KKA, Herath KHINM, Yang HW, Choi CS, Jeon YJ. Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review. Mar Drugs. 2021 Nov 28;19(12). doi: 10.3390/md19120678. PMID: 34940677; PMCID: PMC8703547.
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Unique features of the bifunctional GH30 from Thermothelomyces thermophila revealed by structural and mutational studies.

Carbohydrate polymers

Nikolaivits E, Pentari C, Kosinas C, Feiler CG, Spiliopoulou M, Weiss MS, Dimarogona M, Topakas E.
PMID: 34560965
Carbohydr Polym. 2021 Dec 01;273:118553. doi: 10.1016/j.carbpol.2021.118553. Epub 2021 Aug 12.

Fungal xylanases belonging to family GH30_7, initially categorized as endo-glucuronoxylanases, are now known to differ both in terms of substrate specificity, as well as mode of action. Recently, TtXyn30A, a GH30_7 xylanase from Thermothelomyces thermophila, was shown to possess...

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Nikolaivits E, Pentari C, Kosinas C, et al. Unique features of the bifunctional GH30 from Thermothelomyces thermophila revealed by structural and mutational studies. Carbohydr Polym. 2021;273:118553doi: 10.1016/j.carbpol.2021.118553.
Nikolaivits, E., Pentari, C., Kosinas, C., Feiler, C. G., Spiliopoulou, M., Weiss, M. S., Dimarogona, M., & Topakas, E. (2021). Unique features of the bifunctional GH30 from Thermothelomyces thermophila revealed by structural and mutational studies. Carbohydrate polymers, 273118553. https://doi.org/10.1016/j.carbpol.2021.118553
Nikolaivits, Efstratios, et al. "Unique features of the bifunctional GH30 from Thermothelomyces thermophila revealed by structural and mutational studies." Carbohydrate polymers vol. 273 (2021): 118553. doi: https://doi.org/10.1016/j.carbpol.2021.118553
Nikolaivits E, Pentari C, Kosinas C, Feiler CG, Spiliopoulou M, Weiss MS, Dimarogona M, Topakas E. Unique features of the bifunctional GH30 from Thermothelomyces thermophila revealed by structural and mutational studies. Carbohydr Polym. 2021 Dec 01;273:118553. doi: 10.1016/j.carbpol.2021.118553. Epub 2021 Aug 12. PMID: 34560965.
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Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension.

Journal of controlled release : official journal of the Controlled Release Society

Teng C, Li B, Lin C, Xing X, Huang F, Yang Y, Li Y, Azevedo HS, He W.
PMID: 34896449
J Control Release. 2021 Dec 09;341:591-604. doi: 10.1016/j.jconrel.2021.12.006. Epub 2021 Dec 09.

Pulmonary arterial hypertension (PAH) is an uncommon and deadly cardiopulmonary disease. PAH stems essentially from pulmonary artery (PA) remodeling induced predominantly by over-proliferation of PA smooth muscle cells (PASMCs) and inflammation. However, effective treatments are still missing in the...

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Teng C, Li B, Lin C, et al. Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension. J Control Release. 2021;341:591-604doi: 10.1016/j.jconrel.2021.12.006.
Teng, C., Li, B., Lin, C., Xing, X., Huang, F., Yang, Y., Li, Y., Azevedo, H. S., & He, W. (2021). Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension. Journal of controlled release : official journal of the Controlled Release Society, 341591-604. https://doi.org/10.1016/j.jconrel.2021.12.006
Teng, Chao, et al. "Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension." Journal of controlled release : official journal of the Controlled Release Society vol. 341 (2021): 591-604. doi: https://doi.org/10.1016/j.jconrel.2021.12.006
Teng C, Li B, Lin C, Xing X, Huang F, Yang Y, Li Y, Azevedo HS, He W. Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension. J Control Release. 2021 Dec 09;341:591-604. doi: 10.1016/j.jconrel.2021.12.006. Epub 2021 Dec 09. PMID: 34896449.
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Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension.

Journal of controlled release : official journal of the Controlled Release Society

Teng C, Li B, Lin C, Xing X, Huang F, Yang Y, Li Y, Azevedo HS, He W.
PMID: 34896449
J Control Release. 2021 Dec 09;341:591-604. doi: 10.1016/j.jconrel.2021.12.006. Epub 2021 Dec 09.

Pulmonary arterial hypertension (PAH) is an uncommon and deadly cardiopulmonary disease. PAH stems essentially from pulmonary artery (PA) remodeling induced predominantly by over-proliferation of PA smooth muscle cells (PASMCs) and inflammation. However, effective treatments are still missing in the...

Cite
Teng C, Li B, Lin C, et al. Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension. J Control Release. 2021;341:591-604doi: 10.1016/j.jconrel.2021.12.006.
Teng, C., Li, B., Lin, C., Xing, X., Huang, F., Yang, Y., Li, Y., Azevedo, H. S., & He, W. (2021). Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension. Journal of controlled release : official journal of the Controlled Release Society, 341591-604. https://doi.org/10.1016/j.jconrel.2021.12.006
Teng, Chao, et al. "Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension." Journal of controlled release : official journal of the Controlled Release Society vol. 341 (2021): 591-604. doi: https://doi.org/10.1016/j.jconrel.2021.12.006
Teng C, Li B, Lin C, Xing X, Huang F, Yang Y, Li Y, Azevedo HS, He W. Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension. J Control Release. 2021 Dec 09;341:591-604. doi: 10.1016/j.jconrel.2021.12.006. Epub 2021 Dec 09. PMID: 34896449.
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Angucyclines containing β-ᴅ-glucuronic acid from Streptomyces sp. KCB15JA151.

Bioorganic & medicinal chemistry letters

Kim GS, Jang JP, Oh TH, Kwon M, Lee B, Lee JS, Ko SK, Hong YS, Ahn JS, Jang JH.
PMID: 34216745
Bioorg Med Chem Lett. 2021 Sep 15;48:128237. doi: 10.1016/j.bmcl.2021.128237. Epub 2021 Jul 01.

Two angucyclines, pseudonocardones D (1) and E (2), were isolated from Streptomyces sp. KCB15JA151. The planar structure was elucidated by comprehensive spectroscopic analysis. The absolute configuration of the sugar unit was determined based on the basis of coupling constants,...

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Kim GS, Jang JP, Oh TH, et al. Angucyclines containing β-ᴅ-glucuronic acid from Streptomyces sp. KCB15JA151. Bioorg Med Chem Lett. 2021;48:128237doi: 10.1016/j.bmcl.2021.128237.
Kim, G. S., Jang, J. P., Oh, T. H., Kwon, M., Lee, B., Lee, J. S., Ko, S. K., Hong, Y. S., Ahn, J. S., & Jang, J. H. (2021). Angucyclines containing β-ᴅ-glucuronic acid from Streptomyces sp. KCB15JA151. Bioorganic & medicinal chemistry letters, 48128237. https://doi.org/10.1016/j.bmcl.2021.128237
Kim, Gil Soo, et al. "Angucyclines containing β-ᴅ-glucuronic acid from Streptomyces sp. KCB15JA151." Bioorganic & medicinal chemistry letters vol. 48 (2021): 128237. doi: https://doi.org/10.1016/j.bmcl.2021.128237
Kim GS, Jang JP, Oh TH, Kwon M, Lee B, Lee JS, Ko SK, Hong YS, Ahn JS, Jang JH. Angucyclines containing β-ᴅ-glucuronic acid from Streptomyces sp. KCB15JA151. Bioorg Med Chem Lett. 2021 Sep 15;48:128237. doi: 10.1016/j.bmcl.2021.128237. Epub 2021 Jul 01. PMID: 34216745.
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