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Showing 12565 to 357 of 357 entries
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Identification of Hypoxia-inducible factor (HIF) stabilizer roxadustat and its possible metabolites in thoroughbred horses for doping control.

Drug testing and analysis

Mathew B, Philip M, Perwad Z, Karatt TK, Caveney MR, Subhahar MB, Karakka Kal AK.
PMID: 33569900
Drug Test Anal. 2021 Jun;13(6):1203-1215. doi: 10.1002/dta.3014. Epub 2021 Feb 23.

Hypoxia-inducible factor (HIF) stabilizer belongs to a novel class of pharmacologically active substances, which are capable of inducing the endogenous erythropoietic system. The transcriptional activator HIF has been shown to significantly increase blood hemoglobin and is well set for...

A polysaccharide from Lycium barbarum L.: Structure and protective effects against oxidative stress and high-glucose-induced apoptosis in ARPE-19 cells.

International journal of biological macromolecules

Liu J, Li Y, Pu Q, Qiu H, Di D, Cao Y.
PMID: 34968548
Int J Biol Macromol. 2021 Dec 27;201:111-120. doi: 10.1016/j.ijbiomac.2021.12.139. Epub 2021 Dec 27.

Lycium barbarum polysaccharides (LBPs) are beneficial for vision; however, relevant research has mainly focused on entire crude polysaccharides, with the basis and exact structure of the polysaccharide rarely explored. In this study, LICP009-3F-2a, a novel polysaccharide from Lycium barbarum...

Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway.

International journal of biological macromolecules

Zha Z, Liu Y, Miao Y, Liao S, Wang SY, Tang H, Yin H.
PMID: 34998873
Int J Biol Macromol. 2022 Jan 05;201:47-58. doi: 10.1016/j.ijbiomac.2021.12.098. Epub 2022 Jan 05.

Heparosan, with a linear chain of disaccharide repeating units of → 4) β-D-glucuronic acid (GlcA) (1 → 4)-α-D-N-acetylglucosamine (GlcNAc) (1→, is a potential starting chemical for heparin synthesis. However, the chemoenzymatic synthesis of single-site sulfated heparosan and its antitumor...

Correlation of Acinetobacter baumannii K144 and K86 capsular polysaccharide structures with genes at the K locus reveals the involvement of a novel multifunctional rhamnosyltransferase for structural synthesis.

International journal of biological macromolecules

Kenyon JJ, Kasimova AA, Sviridova AN, Shpirt AM, Shneider MM, Mikhaylova YV, Shelenkov AA, Popova AV, Perepelov AV, Shashkov AS, Dmitrenok AS, Chizov AO, Knirel YA.
PMID: 34757131
Int J Biol Macromol. 2021 Dec 15;193:1294-1300. doi: 10.1016/j.ijbiomac.2021.10.178. Epub 2021 Oct 30.

Whole genome sequence from Acinetobacter baumannii isolate Ab-46-1632 reveals a novel KL144 capsular polysaccharide (CPS) biosynthesis gene cluster, which carries genes for d-glucuronic acid (D-GlcA) and l-rhamnose (l-Rha) synthesis. The CPS was extracted from Ab-46-1632 and studied by

Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway.

International journal of biological macromolecules

Zha Z, Liu Y, Miao Y, Liao S, Wang SY, Tang H, Yin H.
PMID: 34998873
Int J Biol Macromol. 2022 Jan 05;201:47-58. doi: 10.1016/j.ijbiomac.2021.12.098. Epub 2022 Jan 05.

Heparosan, with a linear chain of disaccharide repeating units of → 4) β-D-glucuronic acid (GlcA) (1 → 4)-α-D-N-acetylglucosamine (GlcNAc) (1→, is a potential starting chemical for heparin synthesis. However, the chemoenzymatic synthesis of single-site sulfated heparosan and its antitumor...

Glucose-responsive multifunctional metal-organic drug-loaded hydrogel for diabetic wound healing.

Acta biomaterialia

Yang J, Zeng W, Xu P, Fu X, Yu X, Chen L, Leng F, Yu C, Yang Z.
PMID: 34879294
Acta Biomater. 2021 Dec 05; doi: 10.1016/j.actbio.2021.11.043. Epub 2021 Dec 05.

As the incidence of diabetes increases, its complication, diabetic foot ulcers, has become the main type of clinically chronic refractory wounds. Due to the hyperglycemic microenvironment of the diabetic wound, which leads to vascular defects and bacterial growth, the...

Biomolecular NMR assignments

Osborne MJ, Rahardjo AK, Volpon L, Borden KLB.
PMID: 33870481
Biomol NMR Assign. 2021 Oct;15(2):323-328. doi: 10.1007/s12104-021-10024-9. Epub 2021 Apr 18.

The human UDP-glucuronosyltransferase (UGT) family of enzymes catalyze the covalent addition of glucuronic acid to a wide range of compounds, generally rendering them inactive. Although important for clearance of environmental toxins and metabolites, UGT activation can lead to inappropriate...

Efficient production of xylooligosaccharides rich in xylobiose and xylotriose from poplar by hydrothermal pretreatment coupled with post-enzymatic hydrolysis.

Bioresource technology

Su Y, Fang L, Wang P, Lai C, Huang C, Ling Z, Sun S, Yong Q.
PMID: 34547709
Bioresour Technol. 2021 Dec;342:125955. doi: 10.1016/j.biortech.2021.125955. Epub 2021 Sep 15.

A promising approach for production of value-added xylooligosaccharides (XOS) from poplar was developed by combining hydrothermal pretreatment and endo-xylanase post-hydrolysis. Results showed that the 35.4% XOS (DP 2-6) and 17.6% low DP xylans (DP > 6) were obtained at...

Isolation and immune activity of a new acidic Cordyceps militaris exopolysaccharide.

International journal of biological macromolecules

Yu Y, Wen Q, Song A, Liu Y, Wang F, Jiang B.
PMID: 34813790
Int J Biol Macromol. 2022 Jan 01;194:706-714. doi: 10.1016/j.ijbiomac.2021.11.115. Epub 2021 Nov 20.

A new type of acidic exopolysaccharide (AESP-II) was extracted and separated from the fermentation broth of Cordyceps militaris (C. militaris), which was further purified to elucidate its structural characteristics and immunological activity. AESP-II was confirmed to be an acidic...

Showing 12565 to 357 of 357 entries