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Showing 2341 to 2350 of 2350 entries
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A simple and sensitive detection of the binding ligands by using the receptor aggregation and NMR spectroscopy: a test case of the maltose binding protein.

Journal of biomolecular NMR

Chae YK, Um Y, Kim H.
PMID: 34524563
J Biomol NMR. 2021 Dec;75(10):371-381. doi: 10.1007/s10858-021-00381-x. Epub 2021 Sep 15.

Protein-ligand interaction is one of the highlights of molecular recognition. The most popular application of this type of interaction is drug development which requires a high throughput screening of a ligand that binds to the target protein. Our goal...

Evaluation of the in vivo antihypertensive effect and antioxidant activity of HL-7 and HL-10 peptide in mice.

Molecular biology reports

Setayesh-Mehr Z, Ghasemi LV, Asoodeh A.
PMID: 34291394
Mol Biol Rep. 2021 Jul;48(7):5571-5578. doi: 10.1007/s11033-021-06576-7. Epub 2021 Jul 21.

BACKGROUND: The tendency to use bioactive peptides has increased in recent decades, and research would be essential for recognizing the therapeutic effects of peptides present in animals or food resource. In this study, the in vivo antioxidant and antihypertensive...

Comparative study of structural properties and biological activities of polysaccharides extracted from Chroogomphus rutilus by four different approaches.

International journal of biological macromolecules

Zhao B, Zhao J, Lv M, Li X, Wang J, Yue Z, Shi J, Zhang G, Sui G.
PMID: 34371040
Int J Biol Macromol. 2021 Oct 01;188:215-225. doi: 10.1016/j.ijbiomac.2021.08.025. Epub 2021 Aug 08.

Extraction processes significantly alter the structural and functional properties of polysaccharides. In this study, we extracted polysaccharides from Chroogomphis rutilus fruiting bodies (designated as CRP) using four methods, including hot water, ultrasound, microwave and sequential ultrasound-microwave, and designated these...

An Investigation into the Usage of Monosaccharides with GLUT1 and GLUT3 as Prognostic Indicators for Cancer.

Nutrition and cancer

Gökalp F.
PMID: 33724114
Nutr Cancer. 2021 Mar 16;1-5. doi: 10.1080/01635581.2021.1895233. Epub 2021 Mar 16.

The monosaccharides, glucose, fructose and galactose, are the most common and simplest forms of carbohydrates. The aim of this study was to determine the uptake of glucose as a potential therapeutic target agent for cancer treatment. The stability and...

Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect.

Toxicology reports

Mahmoud MAA, Saleh DO, Safar MM, Agha AM, Khattab MM.
PMID: 33665135
Toxicol Rep. 2021 Feb 15;8:366-375. doi: 10.1016/j.toxrep.2021.02.007. eCollection 2021.

Chloroquine (CQ); a lysosomotropic agent used for decade ago as anti-malarial, was tested against aging induced osteoporosis. Osteoporosis in male rats was induced using d-galactose (D-gal) as a reducing sugar at a dose of 200 mg/kg/day; i.p. Osteoporotic rats...

Comparison of Two Immunoassay Screening Methods and a LC-MS/MS in Detecting Traditional and Designer Benzodiazepines in Urine.

Molecules (Basel, Switzerland)

Rossi B, Freni F, Vignali C, Stramesi C, Collo G, Carelli C, Moretti M, Galatone D, Morini L.
PMID: 35011344
Molecules. 2021 Dec 24;27(1). doi: 10.3390/molecules27010112.

Sensitive and specific immunoassay screening methods for the detection of benzodiazepines in urine represent an important prerequisite for routine analysis in clinical and forensic toxicology. Moreover, emerging designer benzodiazepines force labs to keep their methodologies updated, in order to...

The effects of agomelatine on endoplasmic reticulum stress related to mitochondrial dysfunction in hippocampus of aging rat model.

Chemico-biological interactions

Chanmanee T, Wongpun J, Tocharus C, Govitrapong P, Tocharus J.
PMID: 34673010
Chem Biol Interact. 2021 Oct 19;351:109703. doi: 10.1016/j.cbi.2021.109703. Epub 2021 Oct 19.

BACKGROUND: Agomelatine, a novel antidepressant, is a melatonin MT receptor agonist and serotonin 5HTMETHOD: Hippocampal aging was induced in male Wistar rats by d-galactose (D-gal) intraperitoneal injection (100 mg/kg) for 14 weeks. During the last 4 weeks of D-gal...

Hand fine motor control in classic galactosemia.

Journal of inherited metabolic disease

MacWilliams J, Patel S, Carlock G, Vest S, Potter NL, Fridovich-Keil JL.
PMID: 33720431
J Inherit Metab Dis. 2021 Jul;44(4):871-878. doi: 10.1002/jimd.12376. Epub 2021 Mar 23.

Classic galactosemia (CG) is a rare inborn error of metabolism that results from profound deficiency of galactose-1-P uridylyltransferase (GALT). Despite early detection and rapid and lifelong dietary restriction of galactose, which is the current standard of care, most patients...

The Rgg1518 transcriptional regulator is a necessary facet of sugar metabolism and virulence in Streptococcus pneumoniae.

Molecular microbiology

Shlla B, Gazioglu O, Shafeeq S, Manzoor I, Kuipers OP, Ulijasz A, Hiller NL, Andrew PW, Yesilkaya H.
PMID: 34328238
Mol Microbiol. 2021 Sep;116(3):996-1008. doi: 10.1111/mmi.14788. Epub 2021 Aug 10.

Rggs are a group of transcriptional regulators with diverse roles in metabolism and virulence. Here, we present work on the Rgg1518/SHP1518 quorum sensing system of Streptococcus pneumoniae. The activity of Rgg1518 is induced by its cognate peptide, SHP1518. In...

A novel polysaccharides-based bioflocculant produced by Bacillus subtilis ZHX3 and its application in the treatment of multiple pollutants.

Chemosphere

Xia M, Zhou H, Amanze C, Hu L, Shen L, Yu R, Liu Y, Chen M, Li J, Wu X, Qiu G, Zeng W.
PMID: 34883128
Chemosphere. 2021 Dec 06;289:133185. doi: 10.1016/j.chemosphere.2021.133185. Epub 2021 Dec 06.

A high bioflocculant-producing bacterial strain was identified and named Bacillus subtilis ZHX3. Single-factor experiments suggested that 10 g/L starch and 5 g/L yeast extract were optimal for strain ZHX3 to produce bioflocculant MBF-ZHX3. The maximum flocculating rate reached 95.5%,...

Showing 2341 to 2350 of 2350 entries