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The Teratogenic Effects of Flurazepam Intake during Organogenesis of the Rat Fetus.

Toxicology mechanisms and methods

Takzare N, Hosseini MJ, Bakhtiarian A, Takzare A, Habibi P.
PMID: 20020929
Toxicol Mech Methods. 2008 Jan;18(9):711-6. doi: 10.1080/15376510801897739.

ABSTRACT Flurazepam is a long acting drug with sedative, hypnotic, anxiolytic, relaxant, and anti-epileptic properties. The drug is a benzodiazepine and is commonly used by adults, including pregnant women, intentionally or sometimes unintentionally during their pregnancy. It is increasingly...

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Takzare N, Hosseini MJ, Bakhtiarian A, et al. The Teratogenic Effects of Flurazepam Intake during Organogenesis of the Rat Fetus. Toxicol Mech Methods. 2008;18(9):711-6doi: 10.1080/15376510801897739.
Takzare, N., Hosseini, M. J., Bakhtiarian, A., Takzare, A., & Habibi, P. (2008). The Teratogenic Effects of Flurazepam Intake during Organogenesis of the Rat Fetus. Toxicology mechanisms and methods, 18(9), 711-6. https://doi.org/10.1080/15376510801897739
Takzare, Nasrin, et al. "The Teratogenic Effects of Flurazepam Intake during Organogenesis of the Rat Fetus." Toxicology mechanisms and methods vol. 18,9 (2008): 711-6. doi: https://doi.org/10.1080/15376510801897739
Takzare N, Hosseini MJ, Bakhtiarian A, Takzare A, Habibi P. The Teratogenic Effects of Flurazepam Intake during Organogenesis of the Rat Fetus. Toxicol Mech Methods. 2008 Jan;18(9):711-6. doi: 10.1080/15376510801897739. PMID: 20020929.
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Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABA.

Frontiers in cellular neuroscience

Jatczak-Śliwa M, Terejko K, Brodzki M, Michałowski MA, Czyzewska MM, Nowicka JM, Andrzejczak A, Srinivasan R, Mozrzymas JW.
PMID: 30210295
Front Cell Neurosci. 2018 Aug 28;12:237. doi: 10.3389/fncel.2018.00237. eCollection 2018.

GABA

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Jatczak-Śliwa M, Terejko K, Brodzki M, et al. Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABA. Front Cell Neurosci. 2018;12:237doi: 10.3389/fncel.2018.00237.
Jatczak-Śliwa, M., Terejko, K., Brodzki, M., Michałowski, M. A., Czyzewska, M. M., Nowicka, J. M., Andrzejczak, A., Srinivasan, R., & Mozrzymas, J. W. (2018). Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABA. Frontiers in cellular neuroscience, 12237. https://doi.org/10.3389/fncel.2018.00237
Jatczak-Śliwa, Magdalena, et al. "Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABA." Frontiers in cellular neuroscience vol. 12 (2018): 237. doi: https://doi.org/10.3389/fncel.2018.00237
Jatczak-Śliwa M, Terejko K, Brodzki M, Michałowski MA, Czyzewska MM, Nowicka JM, Andrzejczak A, Srinivasan R, Mozrzymas JW. Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABA. Front Cell Neurosci. 2018 Aug 28;12:237. doi: 10.3389/fncel.2018.00237. eCollection 2018. PMID: 30210295; PMCID: PMC6121034.
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Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA.

British journal of pharmacology

McGrath M, Hoyt H, Pence A, Forman SA, Raines DE.
PMID: 34386973
Br J Pharmacol. 2021 Dec;178(24):4842-4858. doi: 10.1111/bph.15662. Epub 2021 Sep 26.

BACKGROUND AND PURPOSE: In addition to binding to the classical high-affinity extracellular benzodiazepine binding site of the GABAEXPERIMENTAL APPROACH: With flumazenil blocking classical high-affinity extracellular benzodiazepine site effects, modulation of GABA-activated currents by diazepam, midazolam and flurazepam was measured...

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McGrath M, Hoyt H, Pence A, et al. Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA. Br J Pharmacol. 2021;178(24):4842-4858doi: 10.1111/bph.15662.
McGrath, M., Hoyt, H., Pence, A., Forman, S. A., & Raines, D. E. (2021). Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA. British journal of pharmacology, 178(24), 4842-4858. https://doi.org/10.1111/bph.15662
McGrath, Megan, et al. "Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA." British journal of pharmacology vol. 178,24 (2021): 4842-4858. doi: https://doi.org/10.1111/bph.15662
McGrath M, Hoyt H, Pence A, Forman SA, Raines DE. Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA. Br J Pharmacol. 2021 Dec;178(24):4842-4858. doi: 10.1111/bph.15662. Epub 2021 Sep 26. PMID: 34386973; PMCID: PMC8637433.
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NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in F344/N Rats (Feed Studies).

National Toxicology Program technical report series

[No authors listed]
PMID: 12579205
Natl Toxicol Program Tech Rep Ser. 1998 Oct;468:1-189.

Oxazepam and related benzodiazepine drugs are used in the treatment of anxiety. All benzodiazepines currently in use share a number of effects, including sedation, hypnosis, decreased anxiety, muscle relaxation, amnesia, and anticonvulsant activity. Oxazepam and four other benzodiazepines (chlordiazepoxide,...

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NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in F344/N Rats (Feed Studies). Natl Toxicol Program Tech Rep Ser. 1998;468:1-189
(1998). NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in F344/N Rats (Feed Studies). National Toxicology Program technical report series, 4681-189.
"NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in F344/N Rats (Feed Studies)." National Toxicology Program technical report series vol. 468 (1998): 1-189.
NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in F344/N Rats (Feed Studies). Natl Toxicol Program Tech Rep Ser. 1998 Oct;468:1-189. PMID: 12579205.
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Is there a problem with benzodiazepine prescribing in maritime Canada?.

Canadian family physician Medecin de famille canadien

Sketris IS, Maccara ME, Purkis IE, Curry L.
PMID: 21274169
Can Fam Physician. 1985 Sep;31:1591-6.

The benzodiazepine prescribing habits of 64 maritime doctors were studied through collection and examination of carbon copies of all prescriptions over a 22 week period. Diazepam was the most frequently prescribed anxiolytic benzodiazepine, followed by chlordiazepoxide, then oxazepam. These...

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Sketris IS, Maccara ME, Purkis IE, et al. Is there a problem with benzodiazepine prescribing in maritime Canada?. Can Fam Physician. 1985;31:1591-6
Sketris, I. S., Maccara, M. E., Purkis, I. E., & Curry, L. (1985). Is there a problem with benzodiazepine prescribing in maritime Canada?. Canadian family physician Medecin de famille canadien, 311591-6.
Sketris, I S, et al. "Is there a problem with benzodiazepine prescribing in maritime Canada?." Canadian family physician Medecin de famille canadien vol. 31 (1985): 1591-6.
Sketris IS, Maccara ME, Purkis IE, Curry L. Is there a problem with benzodiazepine prescribing in maritime Canada?. Can Fam Physician. 1985 Sep;31:1591-6. PMID: 21274169; PMCID: PMC2327851.
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A new method for the simultaneous determination of 1,4-benzodiazepines and amfepramone as adulterants in phytotherapeutic formulations by voltammetry.

Forensic science international

de Carvalho LM, Correia D, Garcia SC, de Bairros AV, do Nascimento PC, Bohrer D.
PMID: 20472377
Forensic Sci Int. 2010 Oct 10;202(1):75-81. doi: 10.1016/j.forsciint.2010.04.030. Epub 2010 May 15.

The use of synthetic pharmaceuticals in phytotherapeutics can be defined as an illegal practice, since these compounds are normally present as non-declared compounds in the phytotherapeutical formulations. This work aims to show the development of an analytical method based...

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de Carvalho LM, Correia D, Garcia SC, et al. A new method for the simultaneous determination of 1,4-benzodiazepines and amfepramone as adulterants in phytotherapeutic formulations by voltammetry. Forensic Sci Int. 2010;202(1):75-81doi: 10.1016/j.forsciint.2010.04.030.
de Carvalho, L. M., Correia, D., Garcia, S. C., de Bairros, A. V., do Nascimento, P. C., & Bohrer, D. (2010). A new method for the simultaneous determination of 1,4-benzodiazepines and amfepramone as adulterants in phytotherapeutic formulations by voltammetry. Forensic science international, 202(1), 75-81. https://doi.org/10.1016/j.forsciint.2010.04.030
de Carvalho, Leandro M, et al. "A new method for the simultaneous determination of 1,4-benzodiazepines and amfepramone as adulterants in phytotherapeutic formulations by voltammetry." Forensic science international vol. 202,1 (2010): 75-81. doi: https://doi.org/10.1016/j.forsciint.2010.04.030
de Carvalho LM, Correia D, Garcia SC, de Bairros AV, do Nascimento PC, Bohrer D. A new method for the simultaneous determination of 1,4-benzodiazepines and amfepramone as adulterants in phytotherapeutic formulations by voltammetry. Forensic Sci Int. 2010 Oct 10;202(1):75-81. doi: 10.1016/j.forsciint.2010.04.030. Epub 2010 May 15. PMID: 20472377.
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Derivative spectrophotometric method for determination of acidity constants of single step acid-base equilibria.

Talanta

Popović GV, Pfendt LB, Moskovljević VM.
PMID: 18968381
Talanta. 2001 Aug 30;55(2):363-70.

A general derivative spectrophotometric method for determination of acidity constants is developed. The method appears suitable in cases when classical spectrophotometry cannot be employed due to little differences in the absorption spectra of conjugated acid-base pairs. Based on theoretical...

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Popović GV, Pfendt LB, Moskovljević VM. Derivative spectrophotometric method for determination of acidity constants of single step acid-base equilibria. Talanta. 2001;55(2):363-70
Popović, G. V., Pfendt, L. B., & Moskovljević, V. M. (2001). Derivative spectrophotometric method for determination of acidity constants of single step acid-base equilibria. Talanta, 55(2), 363-70.
Popović, G V, et al. "Derivative spectrophotometric method for determination of acidity constants of single step acid-base equilibria." Talanta vol. 55,2 (2001): 363-70.
Popović GV, Pfendt LB, Moskovljević VM. Derivative spectrophotometric method for determination of acidity constants of single step acid-base equilibria. Talanta. 2001 Aug 30;55(2):363-70. PMID: 18968381.
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Deconvolution of ultraviolet absorption spectra of aqueous Diazepam, Flurazepam and Prazepam in acid and alkaline solutions.

Journal of pharmaceutical and biomedical analysis

Gonzalez-Hierro P, Velazquez MM, Cachaza JM, Rodriguez LJ.
PMID: 16867509
J Pharm Biomed Anal. 1987;5(4):395-402. doi: 10.1016/0731-7085(87)80046-8.

No abstract available.

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Gonzalez-Hierro P, Velazquez MM, Cachaza JM, et al. Deconvolution of ultraviolet absorption spectra of aqueous Diazepam, Flurazepam and Prazepam in acid and alkaline solutions. J Pharm Biomed Anal. 1987;5(4):395-402doi: 10.1016/0731-7085(87)80046-8.
Gonzalez-Hierro, P., Velazquez, M. M., Cachaza, J. M., & Rodriguez, L. J. (1987). Deconvolution of ultraviolet absorption spectra of aqueous Diazepam, Flurazepam and Prazepam in acid and alkaline solutions. Journal of pharmaceutical and biomedical analysis, 5(4), 395-402. https://doi.org/10.1016/0731-7085(87)80046-8
Gonzalez-Hierro, P, et al. "Deconvolution of ultraviolet absorption spectra of aqueous Diazepam, Flurazepam and Prazepam in acid and alkaline solutions." Journal of pharmaceutical and biomedical analysis vol. 5,4 (1987): 395-402. doi: https://doi.org/10.1016/0731-7085(87)80046-8
Gonzalez-Hierro P, Velazquez MM, Cachaza JM, Rodriguez LJ. Deconvolution of ultraviolet absorption spectra of aqueous Diazepam, Flurazepam and Prazepam in acid and alkaline solutions. J Pharm Biomed Anal. 1987;5(4):395-402. doi: 10.1016/0731-7085(87)80046-8. PMID: 16867509.
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Quantitative analysis of benzodiazepines in vitreous humor by high-performance liquid chromatography.

SAGE open medicine

Bazmi E, Behnoush B, Akhgari M, Bahmanabadi L.
PMID: 27635251
SAGE Open Med. 2016 Sep 01;4:2050312116666243. doi: 10.1177/2050312116666243. eCollection 2016.

OBJECTIVE: Benzodiazepines are frequently screened drugs in emergency toxicology, drugs of abuse testing, and in forensic cases. As the variations of benzodiazepines concentrations in biological samples during bleeding, postmortem changes, and redistribution could be biasing forensic medicine examinations, hence...

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Bazmi E, Behnoush B, Akhgari M, et al. Quantitative analysis of benzodiazepines in vitreous humor by high-performance liquid chromatography. SAGE Open Med. 2016;4:2050312116666243doi: 10.1177/2050312116666243.
Bazmi, E., Behnoush, B., Akhgari, M., & Bahmanabadi, L. (2016). Quantitative analysis of benzodiazepines in vitreous humor by high-performance liquid chromatography. SAGE open medicine, 42050312116666243. https://doi.org/10.1177/2050312116666243
Bazmi, Elham, et al. "Quantitative analysis of benzodiazepines in vitreous humor by high-performance liquid chromatography." SAGE open medicine vol. 4 (2016): 2050312116666243. doi: https://doi.org/10.1177/2050312116666243
Bazmi E, Behnoush B, Akhgari M, Bahmanabadi L. Quantitative analysis of benzodiazepines in vitreous humor by high-performance liquid chromatography. SAGE Open Med. 2016 Sep 01;4:2050312116666243. doi: 10.1177/2050312116666243. eCollection 2016. PMID: 27635251; PMCID: PMC5011391.
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Past year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a NSDUH study.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Tubbs AS, Ghani SB, Naps M, Grandner MA, Stein MD, Chakravorty S.
PMID: 34666879
J Clin Sleep Med. 2021 Oct 20; doi: 10.5664/jcsm.9724. Epub 2021 Oct 20.

STUDY OBJECTIVES: Prescription use and misuse of opioids are linked to greater sleep disturbance. However, there are limited data on the prevalence of sedative-hypnotic medication use among persons who use opioids. Therefore, this study examined whether past year sedative-hypnotic...

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Tubbs AS, Ghani SB, Naps M, et al. Past year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a NSDUH study. J Clin Sleep Med. 2021;doi: 10.5664/jcsm.9724.
Tubbs, A. S., Ghani, S. B., Naps, M., Grandner, M. A., Stein, M. D., & Chakravorty, S. (2021). Past year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a NSDUH study. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, . https://doi.org/10.5664/jcsm.9724
Tubbs, Andrew S, et al. "Past year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a NSDUH study." Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine vol. (2021). doi: https://doi.org/10.5664/jcsm.9724
Tubbs AS, Ghani SB, Naps M, Grandner MA, Stein MD, Chakravorty S. Past year use or misuse of an opioid is associated with use of a sedative-hypnotic medication: a NSDUH study. J Clin Sleep Med. 2021 Oct 20; doi: 10.5664/jcsm.9724. Epub 2021 Oct 20. PMID: 34666879.
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Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent.

Human psychopharmacology

Patat A, Paty I, Hindmarch I.
PMID: 12404558
Hum Psychopharmacol. 2001 Jul;16(5):369-392. doi: 10.1002/hup.310.

The challenge in developing hypnotic agents for the treatment of insomnia is to balance the sedative effect needed at bedtime with the residual sedation on awakening. Zaleplon is a novel pyrazolopyrimidine hypnotic agent that acts as a selective agonist...

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Patat A, Paty I, Hindmarch I. Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent. Hum Psychopharmacol. 2001;16(5):369-392doi: 10.1002/hup.310.
Patat, A., Paty, I., & Hindmarch, I. (2001). Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent. Human psychopharmacology, 16(5), 369-392. https://doi.org/10.1002/hup.310
Patat, Alain, et al. "Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent." Human psychopharmacology vol. 16,5 (2001): 369-392. doi: https://doi.org/10.1002/hup.310
Patat A, Paty I, Hindmarch I. Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent. Hum Psychopharmacol. 2001 Jul;16(5):369-392. doi: 10.1002/hup.310. PMID: 12404558.
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Differential pulse polarography of some benzodiazepines and their determination in urine.

Talanta

Ellaithy MM, Volke J, Manousek O.
PMID: 18962046
Talanta. 1977 Feb;24(2):137-40. doi: 10.1016/0039-9140(77)80168-9.

A differential pulse polarographic method has been applied to the determination of diazepam, oxazepam, nitrazepam and flurazepam down to 2 x 10(-7)M (0.14 mug/ml). The method can also be used with biological materials such as urine, without prior extraction....

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Ellaithy MM, Volke J, Manousek O. Differential pulse polarography of some benzodiazepines and their determination in urine. Talanta. 1977;24(2):137-40doi: 10.1016/0039-9140(77)80168-9.
Ellaithy, M. M., Volke, J., & Manousek, O. (1977). Differential pulse polarography of some benzodiazepines and their determination in urine. Talanta, 24(2), 137-40. https://doi.org/10.1016/0039-9140(77)80168-9
Ellaithy, M M, et al. "Differential pulse polarography of some benzodiazepines and their determination in urine." Talanta vol. 24,2 (1977): 137-40. doi: https://doi.org/10.1016/0039-9140(77)80168-9
Ellaithy MM, Volke J, Manousek O. Differential pulse polarography of some benzodiazepines and their determination in urine. Talanta. 1977 Feb;24(2):137-40. doi: 10.1016/0039-9140(77)80168-9. PMID: 18962046.
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Showing 1 to 12 of 22 entries