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Showing 25 to 36 of 46 entries
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Revealing Polymorphic Phase Transformations in Polymer-Based Hot Melt Extrusion Processes.

Crystal growth & design

Espinell JRH, López-Mejías V, Stelzer T.
PMID: 31889927
Cryst Growth Des. 2018 Apr 04;18(4):1995-2002. doi: 10.1021/acs.cgd.7b01374. Epub 2018 Mar 09.

The inadvertent occurrence of polymorphic phase transformations in active pharmaceutical ingredients (APIs) during hot melt extrusion (HME) processes has been claimed to limit the application of this technique. Hence, the control of polymorphism would need to be addressed if...

Connexin hemichannel inhibition ameliorates epidermal pathology in a mouse model of keratitis ichthyosis deafness syndrome.

Scientific reports

Sellitto C, Li L, White TW.
PMID: 34916582
Sci Rep. 2021 Dec 16;11(1):24118. doi: 10.1038/s41598-021-03627-8.

Mutations in five different genes encoding connexin channels cause eleven clinically defined human skin diseases. Keratitis ichthyosis deafness (KID) syndrome is caused by point mutations in the GJB2 gene encoding Connexin 26 (Cx26) which result in aberrant activation of...

Transition Metal Complexes with Flufenamic Acid for Pharmaceutical Applications-A Novel Three-Centered Coordination Polymer of Mn(II) Flufenamate.

Materials (Basel, Switzerland)

Gacki M, Kafarska K, Pietrzak A, Szczesio M, Korona-Głowniak I, Wolf WM.
PMID: 32825746
Materials (Basel). 2020 Aug 21;13(17). doi: 10.3390/ma13173705.

Five complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with non-steroidal anti-inflammatory drug, flufenamic acid were synthesized: (1) [Mn

Interaction of wheat germ ca-dependent protein kinases with calmodulin antagonists and polyamines.

Plant physiology

Polya GM, Micucci V.
PMID: 16664554
Plant Physiol. 1985 Dec;79(4):968-72. doi: 10.1104/pp.79.4.968.

The two soluble Ca(2+)-dependent protein kinases resolved from wheat (Triticum aestivum) embryo (protein kinases I and II) are inhibited by the phenothiazine-derived calmodulin antagonists trifluoperazine fluphenazine, and chlorpromazine. Protein kinases I and II are also inhibited by a variety...

Flufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the rat.

Archives of medical science : AMS

Bal R, Ustundag Y, Bulut F, Demir CF, Bal A.
PMID: 26925138
Arch Med Sci. 2016 Feb 01;12(1):208-15. doi: 10.5114/aoms.2016.57597. Epub 2016 Feb 02.

INTRODUCTION: Tinnitus is defined as a phantom auditory sensation, the perception of sound in the absence of external acoustic stimulation. Given that flufenamic acid (FFA) blocks TRPM2 cation channels, resulting in reduced neuronal excitability, we aimed to investigate whether...

An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils.

Frontiers in pharmacology

Foote JR, Behe P, Frampton M, Levine AP, Segal AW.
PMID: 28293191
Front Pharmacol. 2017 Feb 28;8:94. doi: 10.3389/fphar.2017.00094. eCollection 2017.

Neutrophils phagocytosing bacteria and fungi exhibit a burst of non-mitochondrial respiration that is required to kill and digest the engulfed microbes. This respiration is accomplished by the movement of electrons across the wall of the phagocytic vacuole by the...

Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells.

Pulmonary circulation

Yamamura A, Yamamura H, Zeifman A, Yuan JX.
PMID: 22034612
Pulm Circ. 2011 Apr-Jun;1(2):269-79. doi: 10.4103/2045-8932.83447.

Intracellular Ca(2+) plays a fundamental role in regulating cell functions in pulmonary arterial smooth muscle cells (PASMCs). A rise in cytosolic Ca(2+) concentration ([Ca(2+)](cyt)) triggers pulmonary vasoconstriction and stimulates PASMC proliferation. [Ca(2+)](cyt) is increased mainly by Ca(2+) release from...

Screening of emerging contaminants and priority substances (2008/105/EC) in reclaimed water for irrigation and groundwater in a volcanic aquifer (Gran Canaria, Canary Islands, Spain).

The Science of the total environment

Estévez E, Cabrera Mdel C, Molina-Díaz A, Robles-Molina J, Palacios-Díaz Mdel P.
PMID: 22858460
Sci Total Environ. 2012 Sep 01;433:538-46. doi: 10.1016/j.scitotenv.2012.06.031. Epub 2012 Aug 02.

In semiarid regions, reclaimed water can be an important source of emerging pollutants in groundwater. In Gran Canaria Island, reclaimed water irrigation has been practiced for over thirty years and currently represents 8% of water resources. The aim of...

ABC gene-ranking for prediction of drug-induced cholestasis in rats.

Toxicology reports

Cherkas Y, McMillian MK, Amaratunga D, Raghavan N, Sasaki JC.
PMID: 28959545
Toxicol Rep. 2016 Jan 18;3:252-261. doi: 10.1016/j.toxrep.2016.01.009. eCollection 2016.

As legacy toxicogenomics databases have become available, improved data mining approaches are now key to extracting and visualizing subtle relationships between toxicants and gene expression. In the present study, a novel "aggregating bundles of clusters" (ABC) procedure was applied...

Boosting sensitivity and suppressing artifacts via multi-acquisition in direct polarization NMR experiments with small flip-angle pulses.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Fu R, Hernández-Maldonado AJ.
PMID: 29890484
J Magn Reson. 2018 Aug;293:34-40. doi: 10.1016/j.jmr.2018.05.015. Epub 2018 May 24.

A small flip-angle pulse direct polarization is the simplest method commonly used to quantify various compositions in many materials applications. This method sacrifices the sensitivity per scan in exchange for rapid repeating of data acquisition for signal accumulation. In...

Involvement of transient receptor potential melastatin type 7 channels on .

Integrative medicine research

Kim BJ, Lee GS, Kim HW.
PMID: 28664056
Integr Med Res. 2013 Jun;2(2):62-69. doi: 10.1016/j.imr.2013.04.004. Epub 2013 Apr 23.

BACKGROUND: Extracts of METHODS: In the present study, the effects of a methanolic extract of the dried roots of PT on ICC pacemaking activity were examined using the whole-cell patch-clamp technique.RESULTS: The methanolic extract of PT (PTE) was found...

Flufenamic Acid Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells by Antagonizing the PI3K/AKT Signaling Pathway.

Stem cells international

Liu X, Li Z, Liu H, Zhu Y, Xia D, Wang S, Gu R, Zhang P, Liu Y, Zhou Y.
PMID: 32256607
Stem Cells Int. 2020 Mar 16;2020:1540905. doi: 10.1155/2020/1540905. eCollection 2020.

OBJECTIVES: Flufenamic acid (FFA) is a representative of the fenamic acids, an important group of NSAIDs. In the present study, we study the effects of FFA on adipogenesis of human mesenchymal stem cells (MSCs) and we explore the potential...

Showing 25 to 36 of 46 entries