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Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2.

Food & function

Huang TT, Gu PP, Zheng T, Gou LS, Liu YW.
PMID: 34881772
Food Funct. 2022 Jan 04;13(1):242-254. doi: 10.1039/d1fo02932k.

Piperine is reported to ameliorate common metabolic diseases, however, its molecular mechanism is still unclear. In the present study, we examined whether piperine could stimulate glucagon-like peptide-1 (GLP-1) secretion in a human enteroendocrine cell line, Caco-2, and explored the...

Cite
Huang TT, Gu PP, Zheng T, et al. Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2. Food Funct. 2022;13(1):242-254doi: 10.1039/d1fo02932k.
Huang, T. T., Gu, P. P., Zheng, T., Gou, L. S., & Liu, Y. W. (2022). Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2. Food & function, 13(1), 242-254. https://doi.org/10.1039/d1fo02932k
Huang, Ting-Ting, et al. "Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2." Food & function vol. 13,1 (2022): 242-254. doi: https://doi.org/10.1039/d1fo02932k
Huang TT, Gu PP, Zheng T, Gou LS, Liu YW. Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2. Food Funct. 2022 Jan 04;13(1):242-254. doi: 10.1039/d1fo02932k. PMID: 34881772.
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Effects of Co-Solvents on Loading and Release Properties of Self-Assembled Di-Peptide Building Blocks, towards Drug Delivery Applications.

Protein and peptide letters

Yazdani S, Ghoreishi SM, Habibi N.
PMID: 34825860
Protein Pept Lett. 2021 Nov 26; doi: 10.2174/0929866528666211126160432. Epub 2021 Nov 26.

BACKGROUND: Due to their solid-like porous structure, molecular organogel and microcrystal structures have the capabilities of loading drug molecules, encapsulation, and extended release, all considered as essential properties in drug delivery applications. Phases of these structures, however, depend on...

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Yazdani S, Ghoreishi SM, Habibi N. Effects of Co-Solvents on Loading and Release Properties of Self-Assembled Di-Peptide Building Blocks, towards Drug Delivery Applications. Protein Pept Lett. 2021;doi: 10.2174/0929866528666211126160432.
Yazdani, S., Ghoreishi, S. M., & Habibi, N. (2021). Effects of Co-Solvents on Loading and Release Properties of Self-Assembled Di-Peptide Building Blocks, towards Drug Delivery Applications. Protein and peptide letters, . https://doi.org/10.2174/0929866528666211126160432
Yazdani, Sara, et al. "Effects of Co-Solvents on Loading and Release Properties of Self-Assembled Di-Peptide Building Blocks, towards Drug Delivery Applications." Protein and peptide letters vol. (2021). doi: https://doi.org/10.2174/0929866528666211126160432
Yazdani S, Ghoreishi SM, Habibi N. Effects of Co-Solvents on Loading and Release Properties of Self-Assembled Di-Peptide Building Blocks, towards Drug Delivery Applications. Protein Pept Lett. 2021 Nov 26; doi: 10.2174/0929866528666211126160432. Epub 2021 Nov 26. PMID: 34825860.
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Transient and sustained afterdepolarizations in accessory olfactory bulb mitral cells are mediated by distinct mechanisms that are differentially regulated by neuromodulators.

Frontiers in cellular neuroscience

Shpak G, Zylbertal A, Wagner S.
PMID: 25642164
Front Cell Neurosci. 2015 Jan 14;8:432. doi: 10.3389/fncel.2014.00432. eCollection 2014.

Social interactions between mammalian conspecifics rely heavily on molecular communication via the main and accessory olfactory systems. These two chemosensory systems show high similarity in the organization of information flow along their early stages: social chemical cues are detected...

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Shpak G, Zylbertal A, Wagner S. Transient and sustained afterdepolarizations in accessory olfactory bulb mitral cells are mediated by distinct mechanisms that are differentially regulated by neuromodulators. Front Cell Neurosci. 2015;8:432doi: 10.3389/fncel.2014.00432.
Shpak, G., Zylbertal, A., & Wagner, S. (2014). Transient and sustained afterdepolarizations in accessory olfactory bulb mitral cells are mediated by distinct mechanisms that are differentially regulated by neuromodulators. Frontiers in cellular neuroscience, 8432. https://doi.org/10.3389/fncel.2014.00432
Shpak, Guy, et al. "Transient and sustained afterdepolarizations in accessory olfactory bulb mitral cells are mediated by distinct mechanisms that are differentially regulated by neuromodulators." Frontiers in cellular neuroscience vol. 8 (2014): 432. doi: https://doi.org/10.3389/fncel.2014.00432
Shpak G, Zylbertal A, Wagner S. Transient and sustained afterdepolarizations in accessory olfactory bulb mitral cells are mediated by distinct mechanisms that are differentially regulated by neuromodulators. Front Cell Neurosci. 2015 Jan 14;8:432. doi: 10.3389/fncel.2014.00432. eCollection 2014. PMID: 25642164; PMCID: PMC4294165.
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Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2.

Food & function

Huang TT, Gu PP, Zheng T, Gou LS, Liu YW.
PMID: 34881772
Food Funct. 2021 Dec 09; doi: 10.1039/d1fo02932k. Epub 2021 Dec 09.

Piperine is reported to ameliorate common metabolic diseases, however, its molecular mechanism is still unclear. In the present study, we examined whether piperine could stimulate glucagon-like peptide-1 (GLP-1) secretion in a human enteroendocrine cell line, Caco-2, and explored the...

Cite
Huang TT, Gu PP, Zheng T, et al. Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2. Food Funct. 2021;doi: 10.1039/d1fo02932k.
Huang, T. T., Gu, P. P., Zheng, T., Gou, L. S., & Liu, Y. W. (2021). Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2. Food & function, . https://doi.org/10.1039/d1fo02932k
Huang, Ting-Ting, et al. "Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2." Food & function vol. (2021). doi: https://doi.org/10.1039/d1fo02932k
Huang TT, Gu PP, Zheng T, Gou LS, Liu YW. Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2. Food Funct. 2021 Dec 09; doi: 10.1039/d1fo02932k. Epub 2021 Dec 09. PMID: 34881772.
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Accurate and efficient representation of intramolecular energy in ab initio generation of crystal structures. II. Smoothed intramolecular potentials.

Acta crystallographica Section B, Structural science, crystal engineering and materials

Sugden IJ, Adjiman CS, Pantelides CC.
PMID: 32830664
Acta Crystallogr B Struct Sci Cryst Eng Mater. 2019 Jun 01;75:423-433. doi: 10.1107/S2052520619005778. Epub 2019 May 23.

The application of crystal structure prediction (CSP) to industrially relevant molecules requires the handling of increasingly large and flexible compounds. A revised model for the effect of molecular flexibility on the lattice energy that removes the discontinuities and non-differentiabilities...

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Sugden IJ, Adjiman CS, Pantelides CC. Accurate and efficient representation of intramolecular energy in ab initio generation of crystal structures. II. Smoothed intramolecular potentials. Acta Crystallogr B Struct Sci Cryst Eng Mater. 2019;75:423-433doi: 10.1107/S2052520619005778.
Sugden, I. J., Adjiman, C. S., & Pantelides, C. C. (2019). Accurate and efficient representation of intramolecular energy in ab initio generation of crystal structures. II. Smoothed intramolecular potentials. Acta crystallographica Section B, Structural science, crystal engineering and materials, 75423-433. https://doi.org/10.1107/S2052520619005778
Sugden, Isaac J, et al. "Accurate and efficient representation of intramolecular energy in ab initio generation of crystal structures. II. Smoothed intramolecular potentials." Acta crystallographica Section B, Structural science, crystal engineering and materials vol. 75 (2019): 423-433. doi: https://doi.org/10.1107/S2052520619005778
Sugden IJ, Adjiman CS, Pantelides CC. Accurate and efficient representation of intramolecular energy in ab initio generation of crystal structures. II. Smoothed intramolecular potentials. Acta Crystallogr B Struct Sci Cryst Eng Mater. 2019 Jun 01;75:423-433. doi: 10.1107/S2052520619005778. Epub 2019 May 23. PMID: 32830664.
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Regulation of Substantia Nigra Pars Reticulata GABAergic Neuron Activity by H₂O₂ via Flufenamic Acid-Sensitive Channels and K.

Frontiers in systems neuroscience

Lee CR, Witkovsky P, Rice ME.
PMID: 21503158
Front Syst Neurosci. 2011 Apr 04;5:14. doi: 10.3389/fnsys.2011.00014. eCollection 2011.

Substantia nigra pars reticulata (SNr) GABAergic neurons are key output neurons of the basal ganglia. Given the role of these neurons in motor control, it is important to understand factors that regulate their firing rate and pattern. One potential...

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Lee CR, Witkovsky P, Rice ME. Regulation of Substantia Nigra Pars Reticulata GABAergic Neuron Activity by H₂O₂ via Flufenamic Acid-Sensitive Channels and K. Front Syst Neurosci. 2011;5:14doi: 10.3389/fnsys.2011.00014.
Lee, C. R., Witkovsky, P., & Rice, M. E. (2011). Regulation of Substantia Nigra Pars Reticulata GABAergic Neuron Activity by H₂O₂ via Flufenamic Acid-Sensitive Channels and K. Frontiers in systems neuroscience, 514. https://doi.org/10.3389/fnsys.2011.00014
Lee, Christian R, et al. "Regulation of Substantia Nigra Pars Reticulata GABAergic Neuron Activity by H₂O₂ via Flufenamic Acid-Sensitive Channels and K." Frontiers in systems neuroscience vol. 5 (2011): 14. doi: https://doi.org/10.3389/fnsys.2011.00014
Lee CR, Witkovsky P, Rice ME. Regulation of Substantia Nigra Pars Reticulata GABAergic Neuron Activity by H₂O₂ via Flufenamic Acid-Sensitive Channels and K. Front Syst Neurosci. 2011 Apr 04;5:14. doi: 10.3389/fnsys.2011.00014. eCollection 2011. PMID: 21503158; PMCID: PMC3074506.
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Colorimetric determination of two fenamates in capsule dosage form.

Talanta

Mahrous MS, Abdel-Khalek MM, Abdel-Hamid ME.
PMID: 18963983
Talanta. 1985 Aug;32(8):651-3. doi: 10.1016/0039-9140(85)80161-2.

The colorimetric determination of mefenamic acid and flufenamic acid with potassium ferricyanide in sodium hydroxide medium is described. The orange product is measured at 464 nm. The molar absorptivities are 1.9 x 10(3) and 2.9 x 10(3) 1.mole(-1).cm(-1) for...

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Mahrous MS, Abdel-Khalek MM, Abdel-Hamid ME. Colorimetric determination of two fenamates in capsule dosage form. Talanta. 1985;32(8):651-3doi: 10.1016/0039-9140(85)80161-2.
Mahrous, M. S., Abdel-Khalek, M. M., & Abdel-Hamid, M. E. (1985). Colorimetric determination of two fenamates in capsule dosage form. Talanta, 32(8), 651-3. https://doi.org/10.1016/0039-9140(85)80161-2
Mahrous, M S, et al. "Colorimetric determination of two fenamates in capsule dosage form." Talanta vol. 32,8 (1985): 651-3. doi: https://doi.org/10.1016/0039-9140(85)80161-2
Mahrous MS, Abdel-Khalek MM, Abdel-Hamid ME. Colorimetric determination of two fenamates in capsule dosage form. Talanta. 1985 Aug;32(8):651-3. doi: 10.1016/0039-9140(85)80161-2. PMID: 18963983.
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Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs.

Journal of drug delivery

Lee BS, Yoon CW, Osipov A, Moghavem N, Nwachokor D, Amatya R, Na R, Pantoja JL, Pham MD, Black KL, Yu JS.
PMID: 21603162
J Drug Deliv. 2011;2011:980720. doi: 10.1155/2011/980720. Epub 2011 Apr 05.

We demonstrated that hydrophobic derivatives of the nonsteroidal anti-inflammatory drug (NSAID)flufenamic acid (FA), can be formed into stable nanometer-sized prodrugs (nanoprodrugs) that inhibit the growth of glioma cells, suggesting their potential application as anticancer agent. We synthesized highly hydrophobic...

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Lee BS, Yoon CW, Osipov A, et al. Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs. J Drug Deliv. 2011;2011:980720doi: 10.1155/2011/980720.
Lee, B. S., Yoon, C. W., Osipov, A., Moghavem, N., Nwachokor, D., Amatya, R., Na, R., Pantoja, J. L., Pham, M. D., Black, K. L., & Yu, J. S. (2011). Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs. Journal of drug delivery, 2011980720. https://doi.org/10.1155/2011/980720
Lee, Bong-Seop, et al. "Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs." Journal of drug delivery vol. 2011 (2011): 980720. doi: https://doi.org/10.1155/2011/980720
Lee BS, Yoon CW, Osipov A, Moghavem N, Nwachokor D, Amatya R, Na R, Pantoja JL, Pham MD, Black KL, Yu JS. Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs. J Drug Deliv. 2011;2011:980720. doi: 10.1155/2011/980720. Epub 2011 Apr 05. PMID: 21603162; PMCID: PMC3095474.
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Astrocytic connectivity in the hippocampus.

Neuron glia biology

Sul JY, Orosz G, Givens RS, Haydon PG.
PMID: 16575432
Neuron Glia Biol. 2004 Feb;1(1):3-11. doi: 10.1017/s1740925x04000031.

Little is known about the functional connectivity between astrocytes in the CNS. To explore this issue we photo-released glutamate onto a single astrocyte in murine hippocampal slices and imaged calcium responses. Photo-release of glutamate causes a metabotropic glutamate receptor...

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Sul JY, Orosz G, Givens RS, et al. Astrocytic connectivity in the hippocampus. Neuron Glia Biol. 2004;1(1):3-11doi: 10.1017/s1740925x04000031.
Sul, J. Y., Orosz, G., Givens, R. S., & Haydon, P. G. (2004). Astrocytic connectivity in the hippocampus. Neuron glia biology, 1(1), 3-11. https://doi.org/10.1017/s1740925x04000031
Sul, Jai-Yoon, et al. "Astrocytic connectivity in the hippocampus." Neuron glia biology vol. 1,1 (2004): 3-11. doi: https://doi.org/10.1017/s1740925x04000031
Sul JY, Orosz G, Givens RS, Haydon PG. Astrocytic connectivity in the hippocampus. Neuron Glia Biol. 2004 Feb;1(1):3-11. doi: 10.1017/s1740925x04000031. PMID: 16575432; PMCID: PMC1420681.
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Coupling of Caged Molecule Dynamics to JG β-Relaxation: I.

The journal of physical chemistry. B

Capaccioli S, Ngai KL, Thayyil MS, Prevosto D.
PMID: 26090692
J Phys Chem B. 2015 Jul 16;119(28):8800-8. doi: 10.1021/acs.jpcb.5b04408. Epub 2015 Jul 07.

The paper (Sibik, J.; Elliott, S. R.; Zeitler, J. A. J. Phys. Chem. Lett. 2014, 5, 1968-1972) used terahertz time-domain spectroscopy (THz-TDS) to study the dynamics of the polyalcohols, glycerol, threitol, xylitol, and sorbitol, at temperatures from below to...

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Capaccioli S, Ngai KL, Thayyil MS, et al. Coupling of Caged Molecule Dynamics to JG β-Relaxation: I. J Phys Chem B. 2015;119(28):8800-8doi: 10.1021/acs.jpcb.5b04408.
Capaccioli, S., Ngai, K. L., Thayyil, M. S., & Prevosto, D. (2015). Coupling of Caged Molecule Dynamics to JG β-Relaxation: I. The journal of physical chemistry. B, 119(28), 8800-8. https://doi.org/10.1021/acs.jpcb.5b04408
Capaccioli, S, et al. "Coupling of Caged Molecule Dynamics to JG β-Relaxation: I." The journal of physical chemistry. B vol. 119,28 (2015): 8800-8. doi: https://doi.org/10.1021/acs.jpcb.5b04408
Capaccioli S, Ngai KL, Thayyil MS, Prevosto D. Coupling of Caged Molecule Dynamics to JG β-Relaxation: I. J Phys Chem B. 2015 Jul 16;119(28):8800-8. doi: 10.1021/acs.jpcb.5b04408. Epub 2015 Jul 07. PMID: 26090692.
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Possible contribution of pannexin-1 to ATP release in human upper airway epithelia.

Physiological reports

Ohbuchi T, Takenaga F, Hohchi N, Wakasugi T, Ueta Y, Suzuki H.
PMID: 24744896
Physiol Rep. 2014 Feb 10;2(2):e00227. doi: 10.1002/phy2.227. eCollection 2014 Feb 01.

Pannexins are a family of transmembrane nonselective channel proteins that participate in the release of ATP into extracellular space. Previous studies have suggested that pannexin-1 (Panx1) may constitute a local autocrine/paracrine system via transmitter ATP in association with the...

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Ohbuchi T, Takenaga F, Hohchi N, et al. Possible contribution of pannexin-1 to ATP release in human upper airway epithelia. Physiol Rep. 2014;2(2):e00227doi: 10.1002/phy2.227.
Ohbuchi, T., Takenaga, F., Hohchi, N., Wakasugi, T., Ueta, Y., & Suzuki, H. (2014). Possible contribution of pannexin-1 to ATP release in human upper airway epithelia. Physiological reports, 2(2), e00227. https://doi.org/10.1002/phy2.227
Ohbuchi, Toyoaki, et al. "Possible contribution of pannexin-1 to ATP release in human upper airway epithelia." Physiological reports vol. 2,2 (2014): e00227. doi: https://doi.org/10.1002/phy2.227
Ohbuchi T, Takenaga F, Hohchi N, Wakasugi T, Ueta Y, Suzuki H. Possible contribution of pannexin-1 to ATP release in human upper airway epithelia. Physiol Rep. 2014 Feb 10;2(2):e00227. doi: 10.1002/phy2.227. eCollection 2014 Feb 01. PMID: 24744896; PMCID: PMC3966237.
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Response of Fibroblasts MRC-5 to Flufenamic Acid-Grafted MCM-41 Nanoparticles.

Bioengineering (Basel, Switzerland)

Lara GG, Cipreste MF, Andrade GF, Silva WMD, Sousa EMB.
PMID: 29315235
Bioengineering (Basel). 2018 Jan 09;5(1). doi: 10.3390/bioengineering5010004.

Recently, flufenamic acid (FFA) was discovered among fenamates as a free radical scavenger and gap junction blocker; however, its effects have only been studied in cancer cells. Normal cells in the surroundings of a tumor also respond to radiation,...

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Lara GG, Cipreste MF, Andrade GF, et al. Response of Fibroblasts MRC-5 to Flufenamic Acid-Grafted MCM-41 Nanoparticles. Bioengineering (Basel). 2018;5(1)doi: 10.3390/bioengineering5010004.
Lara, G. G., Cipreste, M. F., Andrade, G. F., Silva, W. M. D., & Sousa, E. M. B. (2018). Response of Fibroblasts MRC-5 to Flufenamic Acid-Grafted MCM-41 Nanoparticles. Bioengineering (Basel, Switzerland), 5(1), . https://doi.org/10.3390/bioengineering5010004
Lara, Giovanna Gomes, et al. "Response of Fibroblasts MRC-5 to Flufenamic Acid-Grafted MCM-41 Nanoparticles." Bioengineering (Basel, Switzerland) vol. 5,1 (2018). doi: https://doi.org/10.3390/bioengineering5010004
Lara GG, Cipreste MF, Andrade GF, Silva WMD, Sousa EMB. Response of Fibroblasts MRC-5 to Flufenamic Acid-Grafted MCM-41 Nanoparticles. Bioengineering (Basel). 2018 Jan 09;5(1). doi: 10.3390/bioengineering5010004. PMID: 29315235; PMCID: PMC5874870.
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Showing 13 to 24 of 46 entries