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Showing 13 to 24 of 1439 entries
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Neonatal Formulations: The Need for a Tailored, Knowledge Driven Approach.

Current pharmaceutical design

Allegaert K, Cosaert K, van den Anker JN.
PMID: 26323412
Curr Pharm Des. 2015;21(39):5674-9. doi: 10.2174/1381612821666150901110207.

To attain effective and safe pharmacotherapy in neonates, caregivers have to consider both the clinical characteristics of the newborn and the pharmacokinetic estimates of a given compound during prescription and administration. Overall, clearance in neonates is low when compared...

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Allegaert K, Cosaert K, van den Anker JN. Neonatal Formulations: The Need for a Tailored, Knowledge Driven Approach. Curr Pharm Des. 2015;21(39):5674-9doi: 10.2174/1381612821666150901110207.
Allegaert, K., Cosaert, K., & van den Anker, J. N. (2015). Neonatal Formulations: The Need for a Tailored, Knowledge Driven Approach. Current pharmaceutical design, 21(39), 5674-9. https://doi.org/10.2174/1381612821666150901110207
Allegaert, Karel, et al. "Neonatal Formulations: The Need for a Tailored, Knowledge Driven Approach." Current pharmaceutical design vol. 21,39 (2015): 5674-9. doi: https://doi.org/10.2174/1381612821666150901110207
Allegaert K, Cosaert K, van den Anker JN. Neonatal Formulations: The Need for a Tailored, Knowledge Driven Approach. Curr Pharm Des. 2015;21(39):5674-9. doi: 10.2174/1381612821666150901110207. PMID: 26323412.
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Safety of Excipients in Pediatric Formulations-A Call for Toxicity Studies in Juvenile Animals?.

Children (Basel, Switzerland)

Schmitt G.
PMID: 27417358
Children (Basel). 2015 May 15;2(2):191-7. doi: 10.3390/children2020191.

The development of drug products for pediatric use often requires age-appropriate formulations which can be more complex and may involve a broader range of excipients than adult dosage forms. Excipients established for adult use are not always appropriate for...

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Schmitt G. Safety of Excipients in Pediatric Formulations-A Call for Toxicity Studies in Juvenile Animals?. Children (Basel). 2015;2(2):191-7doi: 10.3390/children2020191.
Schmitt, G. (2015). Safety of Excipients in Pediatric Formulations-A Call for Toxicity Studies in Juvenile Animals?. Children (Basel, Switzerland), 2(2), 191-7. https://doi.org/10.3390/children2020191
Schmitt, Georg. "Safety of Excipients in Pediatric Formulations-A Call for Toxicity Studies in Juvenile Animals?." Children (Basel, Switzerland) vol. 2,2 (2015): 191-7. doi: https://doi.org/10.3390/children2020191
Schmitt G. Safety of Excipients in Pediatric Formulations-A Call for Toxicity Studies in Juvenile Animals?. Children (Basel). 2015 May 15;2(2):191-7. doi: 10.3390/children2020191. PMID: 27417358; PMCID: PMC4928760.
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Preparation of active 3D film patches via aligned fiber electrohydrodynamic (EHD) printing.

Scientific reports

Wang JC, Zheng H, Chang MW, Ahmad Z, Li JS.
PMID: 28272513
Sci Rep. 2017 Mar 08;7:43924. doi: 10.1038/srep43924.

The design, preparation and application of three-dimensional (3D) printed structures have gained appreciable interest in recent times, particularly for drug dosage development. In this study, the electrohydrodynamic (EHD) printing technique was developed to fabricate aligned-fiber antibiotic (tetracycline hydrochloride, TE-HCL)...

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Wang JC, Zheng H, Chang MW, et al. Preparation of active 3D film patches via aligned fiber electrohydrodynamic (EHD) printing. Sci Rep. 2017;7:43924doi: 10.1038/srep43924.
Wang, J. C., Zheng, H., Chang, M. W., Ahmad, Z., & Li, J. S. (2017). Preparation of active 3D film patches via aligned fiber electrohydrodynamic (EHD) printing. Scientific reports, 743924. https://doi.org/10.1038/srep43924
Wang, Jun-Chuan, et al. "Preparation of active 3D film patches via aligned fiber electrohydrodynamic (EHD) printing." Scientific reports vol. 7 (2017): 43924. doi: https://doi.org/10.1038/srep43924
Wang JC, Zheng H, Chang MW, Ahmad Z, Li JS. Preparation of active 3D film patches via aligned fiber electrohydrodynamic (EHD) printing. Sci Rep. 2017 Mar 08;7:43924. doi: 10.1038/srep43924. PMID: 28272513; PMCID: PMC5341077.
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Stability-Indicating HPLC Method for the Simultaneous Determination of HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate, and Rilpivirine Hydrochloride in Pharmaceutical Dosage Forms.

International scholarly research notices

Venkatesan S, Kannappan N, Mannemala SS.
PMID: 27437485
Int Sch Res Notices. 2014 Oct 29;2014:849149. doi: 10.1155/2014/849149. eCollection 2014.

A simple, accurate, rapid, and stability-indicating RP-HPLC method for a combination of tenofovir disoproxil fumarate, emtricitabine, and rilpivirine has been developed and subsequently validated in commercial tablets. The proposed HPLC method utilizes Phenomenex Gemini C18 column (150 mm ×...

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Venkatesan S, Kannappan N, Mannemala SS. Stability-Indicating HPLC Method for the Simultaneous Determination of HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate, and Rilpivirine Hydrochloride in Pharmaceutical Dosage Forms. Int Sch Res Notices. 2014;2014:849149doi: 10.1155/2014/849149.
Venkatesan, S., Kannappan, N., & Mannemala, S. S. (2014). Stability-Indicating HPLC Method for the Simultaneous Determination of HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate, and Rilpivirine Hydrochloride in Pharmaceutical Dosage Forms. International scholarly research notices, 2014849149. https://doi.org/10.1155/2014/849149
Venkatesan, S, et al. "Stability-Indicating HPLC Method for the Simultaneous Determination of HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate, and Rilpivirine Hydrochloride in Pharmaceutical Dosage Forms." International scholarly research notices vol. 2014 (2014): 849149. doi: https://doi.org/10.1155/2014/849149
Venkatesan S, Kannappan N, Mannemala SS. Stability-Indicating HPLC Method for the Simultaneous Determination of HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate, and Rilpivirine Hydrochloride in Pharmaceutical Dosage Forms. Int Sch Res Notices. 2014 Oct 29;2014:849149. doi: 10.1155/2014/849149. eCollection 2014. PMID: 27437485; PMCID: PMC4897060.
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Suppression of IgM Proteolysis by Conformational Stabilization Through Excipients.

Scientia pharmaceutica

Mueller M, Loh MQ, Gagnon P.
PMID: 26839826
Sci Pharm. 2015 Mar 04;83(2):401-10. doi: 10.3797/scipharm.1501-12. Print 2015.

Protease activity from host cell lines may cause product loss or affect the quality of recombinant proteins. In this study, we showed that excipients like glycine and sorbitol reduce the proteolysis of an immunoglobulin M (IgM) in the presence...

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Mueller M, Loh MQ, Gagnon P. Suppression of IgM Proteolysis by Conformational Stabilization Through Excipients. Sci Pharm. 2015;83(2):401-10doi: 10.3797/scipharm.1501-12.
Mueller, M., Loh, M. Q., & Gagnon, P. (2015). Suppression of IgM Proteolysis by Conformational Stabilization Through Excipients. Scientia pharmaceutica, 83(2), 401-10. https://doi.org/10.3797/scipharm.1501-12
Mueller, Monika, et al. "Suppression of IgM Proteolysis by Conformational Stabilization Through Excipients." Scientia pharmaceutica vol. 83,2 (2015): 401-10. doi: https://doi.org/10.3797/scipharm.1501-12
Mueller M, Loh MQ, Gagnon P. Suppression of IgM Proteolysis by Conformational Stabilization Through Excipients. Sci Pharm. 2015 Mar 04;83(2):401-10. doi: 10.3797/scipharm.1501-12. Print 2015. PMID: 26839826; PMCID: PMC4727821.
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High-throughput formulation screening of therapeutic proteins.

Drug discovery today. Technologies

Capelle MA, Arvinte T.
PMID: 24981094
Drug Discov Today Technol. 2008;5(2):e71-9. doi: 10.1016/j.ddtec.2009.03.003.

High-throughput screening (HTS) is used extensively in drug discovery to identify active compounds. Automated preparation and sample analysis in multiwell plates using a combination of liquid and/or powder handling stations, robotics and sensitive detection devices provide powerful tools. At...

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Capelle MA, Arvinte T. High-throughput formulation screening of therapeutic proteins. Drug Discov Today Technol. 2008;5(2):e71-9doi: 10.1016/j.ddtec.2009.03.003.
Capelle, M. A., & Arvinte, T. (2008). High-throughput formulation screening of therapeutic proteins. Drug discovery today. Technologies, 5(2), e71-9. https://doi.org/10.1016/j.ddtec.2009.03.003
Capelle, Martinus A H, and Arvinte, Tudor. "High-throughput formulation screening of therapeutic proteins." Drug discovery today. Technologies vol. 5,2 (2008): e71-9. doi: https://doi.org/10.1016/j.ddtec.2009.03.003
Capelle MA, Arvinte T. High-throughput formulation screening of therapeutic proteins. Drug Discov Today Technol. 2008;5(2):e71-9. doi: 10.1016/j.ddtec.2009.03.003. PMID: 24981094.
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Application of SeDeM Expert system in formulation development of effervescent tablets by direct compression.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Khan A, Iqbal Z, Rehman Z, Nasir F, Khan A, Ismail M, Roohullah, Mohammad A.
PMID: 25473332
Saudi Pharm J. 2014 Nov;22(5):433-44. doi: 10.1016/j.jsps.2013.07.002. Epub 2013 Aug 08.

The SeDeM expert system is a pre formulation tool applied for the prediction of the suitability of a material for direct compression. This innovative tool provides an index of good compressibility of the material indicating its aptitude to be...

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Khan A, Iqbal Z, Rehman Z, et al. Application of SeDeM Expert system in formulation development of effervescent tablets by direct compression. Saudi Pharm J. 2013;22(5):433-44doi: 10.1016/j.jsps.2013.07.002.
Khan, A., Iqbal, Z., Rehman, Z., Nasir, F., Khan, A., Ismail, M., Roohullah, & Mohammad, A. (2014). Application of SeDeM Expert system in formulation development of effervescent tablets by direct compression. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 22(5), 433-44. https://doi.org/10.1016/j.jsps.2013.07.002
Khan, Amjad, et al. "Application of SeDeM Expert system in formulation development of effervescent tablets by direct compression." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 22,5 (2014): 433-44. doi: https://doi.org/10.1016/j.jsps.2013.07.002
Khan A, Iqbal Z, Rehman Z, Nasir F, Khan A, Ismail M, Roohullah, Mohammad A. Application of SeDeM Expert system in formulation development of effervescent tablets by direct compression. Saudi Pharm J. 2014 Nov;22(5):433-44. doi: 10.1016/j.jsps.2013.07.002. Epub 2013 Aug 08. PMID: 25473332; PMCID: PMC4246396.
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Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry: A Case Study on Cornus officinalis.

Evidence-based complementary and alternative medicine : eCAM

Cao G, Cai H, Yue X, Tu S, Cai B, Xu Z.
PMID: 23737825
Evid Based Complement Alternat Med. 2013;2013:306712. doi: 10.1155/2013/306712. Epub 2013 Apr 29.

Ultrahigh-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-QTOF/MS) was developed for rapid and sensitive analysis of the effect of rice wine on the metabolites of the main components of herbal medicine in rat urine. Using Cornus officinalis as a model of...

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Cao G, Cai H, Yue X, et al. Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry: A Case Study on Cornus officinalis. Evid Based Complement Alternat Med. 2013;2013:306712doi: 10.1155/2013/306712.
Cao, G., Cai, H., Yue, X., Tu, S., Cai, B., & Xu, Z. (2013). Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry: A Case Study on Cornus officinalis. Evidence-based complementary and alternative medicine : eCAM, 2013306712. https://doi.org/10.1155/2013/306712
Cao, Gang, et al. "Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry: A Case Study on Cornus officinalis." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 306712. doi: https://doi.org/10.1155/2013/306712
Cao G, Cai H, Yue X, Tu S, Cai B, Xu Z. Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry: A Case Study on Cornus officinalis. Evid Based Complement Alternat Med. 2013;2013:306712. doi: 10.1155/2013/306712. Epub 2013 Apr 29. PMID: 23737825; PMCID: PMC3657418.
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Interpenetrating polymer networks as innovative drug delivery systems.

Journal of drug delivery

Lohani A, Singh G, Bhattacharya SS, Verma A.
PMID: 24949205
J Drug Deliv. 2014;2014:583612. doi: 10.1155/2014/583612. Epub 2014 May 14.

Polymers have always been valuable excipients in conventional dosage forms, also have shown excellent performance into the parenteral arena, and are now capable of offering advanced and sophisticated functions such as controlled drug release and drug targeting. Advances in...

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Lohani A, Singh G, Bhattacharya SS, et al. Interpenetrating polymer networks as innovative drug delivery systems. J Drug Deliv. 2014;2014:583612doi: 10.1155/2014/583612.
Lohani, A., Singh, G., Bhattacharya, S. S., & Verma, A. (2014). Interpenetrating polymer networks as innovative drug delivery systems. Journal of drug delivery, 2014583612. https://doi.org/10.1155/2014/583612
Lohani, Alka, et al. "Interpenetrating polymer networks as innovative drug delivery systems." Journal of drug delivery vol. 2014 (2014): 583612. doi: https://doi.org/10.1155/2014/583612
Lohani A, Singh G, Bhattacharya SS, Verma A. Interpenetrating polymer networks as innovative drug delivery systems. J Drug Deliv. 2014;2014:583612. doi: 10.1155/2014/583612. Epub 2014 May 14. PMID: 24949205; PMCID: PMC4052081.
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The influence of formulation and manufacturing process parameters on the characteristics of lyophilized orally disintegrating tablets.

Pharmaceutics

Jones RJ, Rajabi-Siahboomi A, Levina M, Perrie Y, Mohammed AR.
PMID: 24310589
Pharmaceutics. 2011 Jul 20;3(3):440-57. doi: 10.3390/pharmaceutics3030440.

Gelatin is a principal excipient used as a binder in the formulation of lyophilized orally disintegrating tablets. The current study focuses on exploiting the physicochemical properties of gelatin by varying formulation parameters to determine their influence on orally disintegrating...

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Jones RJ, Rajabi-Siahboomi A, Levina M, et al. The influence of formulation and manufacturing process parameters on the characteristics of lyophilized orally disintegrating tablets. Pharmaceutics. 2011;3(3):440-57doi: 10.3390/pharmaceutics3030440.
Jones, R. J., Rajabi-Siahboomi, A., Levina, M., Perrie, Y., & Mohammed, A. R. (2011). The influence of formulation and manufacturing process parameters on the characteristics of lyophilized orally disintegrating tablets. Pharmaceutics, 3(3), 440-57. https://doi.org/10.3390/pharmaceutics3030440
Jones, Rhys J, et al. "The influence of formulation and manufacturing process parameters on the characteristics of lyophilized orally disintegrating tablets." Pharmaceutics vol. 3,3 (2011): 440-57. doi: https://doi.org/10.3390/pharmaceutics3030440
Jones RJ, Rajabi-Siahboomi A, Levina M, Perrie Y, Mohammed AR. The influence of formulation and manufacturing process parameters on the characteristics of lyophilized orally disintegrating tablets. Pharmaceutics. 2011 Jul 20;3(3):440-57. doi: 10.3390/pharmaceutics3030440. PMID: 24310589; PMCID: PMC3857075.
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Isolation and Evaluation of Mucilage of Adansonia digitata Linn as a Suspending Agent.

Journal of pharmaceutics

Deshmukh SS, Katare YS, Shyale SS, Bhujbal SS, Kadam SD, Landge DA, Shah DV, Pawar JB.
PMID: 26709363
J Pharm (Cairo). 2013;2013:379750. doi: 10.1155/2013/379750. Epub 2013 Dec 24.

Natural excipients can serve as alternative to synthetic products because of local accessibility, biodegradability, eco-friendly nature and cost effectiveness as compared to synthetic products. Therefore, it is a current need to explore natural excipients that can be used as...

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Deshmukh SS, Katare YS, Shyale SS, et al. Isolation and Evaluation of Mucilage of Adansonia digitata Linn as a Suspending Agent. J Pharm (Cairo). 2013;2013:379750doi: 10.1155/2013/379750.
Deshmukh, S. S., Katare, Y. S., Shyale, S. S., Bhujbal, S. S., Kadam, S. D., Landge, D. A., Shah, D. V., & Pawar, J. B. (2013). Isolation and Evaluation of Mucilage of Adansonia digitata Linn as a Suspending Agent. Journal of pharmaceutics, 2013379750. https://doi.org/10.1155/2013/379750
Deshmukh, S S, et al. "Isolation and Evaluation of Mucilage of Adansonia digitata Linn as a Suspending Agent." Journal of pharmaceutics vol. 2013 (2013): 379750. doi: https://doi.org/10.1155/2013/379750
Deshmukh SS, Katare YS, Shyale SS, Bhujbal SS, Kadam SD, Landge DA, Shah DV, Pawar JB. Isolation and Evaluation of Mucilage of Adansonia digitata Linn as a Suspending Agent. J Pharm (Cairo). 2013;2013:379750. doi: 10.1155/2013/379750. Epub 2013 Dec 24. PMID: 26709363; PMCID: PMC4590786.
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Somatotropin delivery to farmed animals.

Advanced drug delivery reviews

Foster TP.
PMID: 10837754
Adv Drug Deliv Rev. 1999 Jul 26;38(2):151-165. doi: 10.1016/s0169-409x(99)00014-9.

Bovine somatotropin (bST) is marketed worldwide for increased milk production in cows while porcine somatotropin (pST) is approved in one country for increasing growth in swine. Somatotropin physicochemical properties, animal production method limitations and the need for cost effectiveness...

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Foster TP. Somatotropin delivery to farmed animals. Adv Drug Deliv Rev. 1999;38(2):151-165doi: 10.1016/s0169-409x(99)00014-9.
Foster, T. P. (1999). Somatotropin delivery to farmed animals. Advanced drug delivery reviews, 38(2), 151-165. https://doi.org/10.1016/s0169-409x(99)00014-9
Foster. "Somatotropin delivery to farmed animals." Advanced drug delivery reviews vol. 38,2 (1999): 151-165. doi: https://doi.org/10.1016/s0169-409x(99)00014-9
Foster TP. Somatotropin delivery to farmed animals. Adv Drug Deliv Rev. 1999 Jul 26;38(2):151-165. doi: 10.1016/s0169-409x(99)00014-9. PMID: 10837754.
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Showing 13 to 24 of 1439 entries