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Showing 445 to 451 of 451 entries
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Effect of sacubitril/valsartan on investigator-reported ventricular arrhythmias in PARADIGM-HF.

European journal of heart failure

Curtain JP, Jackson A, Shen L, Jhund PS, Docherty KF, Petrie MC, Castagno D, Desai AS, Rohde LE, Lefkowitz MP, Rouleau JL, Zile MR, Solomon SD, Swedberg K, Packer M, McMurray JJV.
PMID: 34969175
Eur J Heart Fail. 2021 Dec 30; doi: 10.1002/ejhf.2419. Epub 2021 Dec 30.

BACKGROUND: Sudden death is a leading cause of mortality in HFrEF. In PARADIGM-HF, sacubitril/valsartan reduced the incidence of sudden death. The purpose of this post hoc study was to analyze the effect of sacubitril/valsartan, compared to enalapril, on the...

Hexahydrocurcumin ameliorates hypertensive and vascular remodeling in L-NAME-induced rats.

Biochimica et biophysica acta. Molecular basis of disease

Panthiya L, Tocharus J, Onsa-Ard A, Chaichompoo W, Suksamrarn A, Tocharus C.
PMID: 34883248
Biochim Biophys Acta Mol Basis Dis. 2021 Dec 07;1868(3):166317. doi: 10.1016/j.bbadis.2021.166317. Epub 2021 Dec 07.

Hexahydrocurcumin (HHC), a major metabolite of curcumin, possesses several biological activities such as antioxidant, anti-inflammation, and cardioprotective properties. This study aimed to investigate the effect of HHC on high blood pressure, vascular dysfunction, and remodeling induced by N-nitro L-arginine...

Intravital imaging reveals glomerular capillary distension and endothelial and immune cell activation early in Alport syndrome.

JCI insight

Gyarmati G, Shroff UN, Izuhara A, Hou X, Da Sacco S, Sedrakyan S, Lemley KV, Amann K, Perin L, Peti-Peterdi J.
PMID: 34793332
JCI Insight. 2021 Nov 18; doi: 10.1172/jci.insight.152676. Epub 2021 Nov 18.

Alport syndrome (AS) is a genetic disorder caused by mutations in type IV collagen that leads to defective glomerular basement membrane, glomerular filtration barrier (GFB) damage, and progressive chronic kidney disease. While the genetic basis of AS is well...

Finding a cell-permeable compound to inhibit inflammatory cytokines: Uptake, biotransformation, and anti-cytokine activity of javamide-I/-II esters.

Life sciences

Park JB.
PMID: 34982964
Life Sci. 2022 Jan 01;291:120280. doi: 10.1016/j.lfs.2021.120280. Epub 2022 Jan 01.

AIM: Currently, there is limited information available about cell-permeability and anti-cytokine activity of javamide-I/-II esters in monocyte/macrophage-like cells. Therefore, the aim of this study was to investigate their cell-permeability and anti-cytokine activity in the cells.MATERIALS AND METHODS: The uptake...

A Randomized Crossover Pilot Study Examining the Effect of Carvedilol and Terazosin plus Enalapril on Urinary Symptoms of Patients with Hypertension and Benign Prostatic Hyperplasia.

Urology journal

Farshi A, DalirAkbari N, Zomorrodi A, Khalili M, Mahmoudinezhad M.
PMID: 33840085
Urol J. 2021 Apr 11;18(3):337-342. doi: 10.22037/uj.v18i.5678.

PURPOSE: The present study aims to assess and compare the effects of carvedilol and terazosin plus enalapril on lower urinary tract symptoms (LUTS), the urine flow, and blood pressure (BP) in patients with moderate hypertension (HTN) and benign prostatic...

Hexahydrocurcumin ameliorates hypertensive and vascular remodeling in L-NAME-induced rats.

Biochimica et biophysica acta. Molecular basis of disease

Panthiya L, Tocharus J, Onsa-Ard A, Chaichompoo W, Suksamrarn A, Tocharus C.
PMID: 34883248
Biochim Biophys Acta Mol Basis Dis. 2021 Dec 07;1868(3):166317. doi: 10.1016/j.bbadis.2021.166317. Epub 2021 Dec 07.

Hexahydrocurcumin (HHC), a major metabolite of curcumin, possesses several biological activities such as antioxidant, anti-inflammation, and cardioprotective properties. This study aimed to investigate the effect of HHC on high blood pressure, vascular dysfunction, and remodeling induced by N-nitro L-arginine...

Comparing Sacubitril/Valsartan Against Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure: A Systematic Review and Network Meta-analysis.

Clinical drug investigation

Teo YN, Teo YH, Syn NL, Yoong CSY, Cheong AJY, Wee CF, Lim YC, Lee CH, Yeo TC, Chai P, Wong RCC, Lin W, Sia CH.
PMID: 34797518
Clin Drug Investig. 2022 Jan;42(1):1-16. doi: 10.1007/s40261-021-01098-3. Epub 2021 Nov 19.

BACKGROUND AND OBJECTIVE: In recent trials, sodium-glucose cotransporter 2 (SGLT2) inhibitors proved effective as treatment for heart failure. However, the relative efficacy of sacubitril/valsartan against SGLT2 inhibitor in patients with heart failure remains unknown. Hence, we performed a network...

Showing 445 to 451 of 451 entries