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Showing 277 to 281 of 281 entries
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20-hydroxyecdysone (20E) signaling regulates amnioserosa morphogenesis during Drosophila dorsal closure: EcR modulates gene expression in a complex with the AP-1 subunit, Jun.

Biology open

Yoo B, Kim HY, Chen X, Shen W, Jang JS, Stein SN, Cormier O, Pereira L, Shih CRY, Krieger C, Reed B, Harden N, Wang SJH.
PMID: 34296248
Biol Open. 2021 Aug 15;10(8). doi: 10.1242/bio.058605. Epub 2021 Aug 17.

Steroid hormones influence diverse biological processes throughout the animal life cycle, including metabolism, stress resistance, reproduction, and lifespan. In insects, the steroid hormone, 20-hydroxyecdysone (20E), is the central hormone regulator of molting and metamorphosis, and plays roles in tissue...

Drosophila Keap1 xenobiotic response factor regulates developmental transcription through binding to chromatin.

Developmental biology

Carlson J, Price L, Cook I, Deng H.
PMID: 34662537
Dev Biol. 2022 Jan;481:139-147. doi: 10.1016/j.ydbio.2021.10.003. Epub 2021 Oct 15.

The Keap1-Nrf2 complex is a central regulator that mediates transcriptional responses to xenobiotic stimuli and is highly related with multiple human diseases. The molecular mechanisms and biological functions of Keap1 and Nrf2 are not fully understood. The Drosophila Keap1...

Characterization of Two Small Heat Shock Protein Genes (.

Insects

Zhao J, Huang Q, Zhang G, Zhu-Salzman K, Cheng W.
PMID: 33572953
Insects. 2021 Jan 29;12(2). doi: 10.3390/insects12020119.

No abstract available.

Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP.

Journal of pesticide science

Browning C, McEwen AG, Mori K, Yokoi T, Moras D, Nakagawa Y, Billas IML.
PMID: 33746550
J Pestic Sci. 2021 Feb 20;46(1):88-100. doi: 10.1584/jpestics.D20-095.

The ecdysone receptor (EcR) possesses the remarkable capacity to adapt structurally to different types of ligands. EcR binds ecdysteroids, including 20-hydroxyecdysone (20E), as well as nonsteroidal synthetic agonists such as insecticidal dibenzoylhydrazines (DBHs). Here, we report the crystal structures...

Co-option of immune effectors by the hormonal signalling system triggering metamorphosis in Drosophila melanogaster.

PLoS genetics

Nunes C, Koyama T, Sucena É.
PMID: 34843450
PLoS Genet. 2021 Nov 29;17(11):e1009916. doi: 10.1371/journal.pgen.1009916. eCollection 2021 Nov.

Insect metamorphosis is triggered by the production, secretion and degradation of 20-hydroxyecdysone (ecdysone). In addition to its role in developmental regulation, increasing evidence suggests that ecdysone is involved in innate immunity processes, such as phagocytosis and the induction of...

Showing 277 to 281 of 281 entries