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Showing 37 to 48 of 56 entries
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Upcoming ISSX Meetings.

Drug metabolism reviews

[No authors listed]
PMID: 27418301
Drug Metab Rev. 2016 Jul;48:5. doi: 10.1080/03602532.2016.1191849.

No abstract available.

Prediction of drug-induced kidney injury in drug discovery.

Drug metabolism reviews

Kulkarni P.
PMID: 34000943
Drug Metab Rev. 2021 May;53(2):234-244. doi: 10.1080/03602532.2021.1922436. Epub 2021 May 17.

Drug induced kidney injury is one of the leading causes of failure of drug development programs in the clinic. Early prediction of renal toxicity potential of drugs is crucial to the success of drug candidates in the clinic. The...

Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes.

Human mutation

Welch RA, Lazaruk K, Haque KA, Hyland F, Xiao N, Wronka L, Burdett L, Chanock SJ, Ingber D, De La Vega FM, Yeager M.
PMID: 18327779
Hum Mutat. 2008 May;29(5):750-6. doi: 10.1002/humu.20703.

A class of genes, known as drug metabolism enzymes (DMEs) are responsible for the metabolism and transport of drugs and other xenobiotics. Variation in DME genes most likely accounts for a proportion of the variability in drug response in...

20th North American ISSX Meeting 18-22 October 2015Orlando, Florida, USA.

Drug metabolism reviews

[No authors listed]
PMID: 27418299
Drug Metab Rev. 2016 Jul;48:2-3. doi: 10.1080/03602532.2016.1191846.

No abstract available.

20th North American ISSX Meeting.

Drug metabolism reviews

[No authors listed]
PMID: 27418305
Drug Metab Rev. 2016 Jul;48:158-64. doi: 10.1080/03602532.2016.1191841.

No abstract available.

Abstracts from the 19th North American ISSX and 29th JSSX Meeting.

Drug metabolism reviews

[No authors listed]
PMID: 26247907
Drug Metab Rev. 2015;47:1. doi: 10.3109/03602532.2015.1071937. Epub 2015 Oct 02.

No abstract available.

Abstracts from the DMW/ISSX 2000 Meeting.

Drug metabolism reviews

[No authors listed]
PMID: 28256155
Drug Metab Rev. 2000 Dec;32:vii-120. doi: 10.1080/03602532.2000.11864614.

No abstract available.

Cytochrome P450 expression and regulation in the brain.

Drug metabolism reviews

Kuban W, Daniel WA.
PMID: 33356626
Drug Metab Rev. 2021 Feb;53(1):1-29. doi: 10.1080/03602532.2020.1858856. Epub 2020 Dec 27.

The regulation of brain cytochrome P450 enzymes (CYPs) is different compared with respective hepatic enzymes. This may result from anatomical bases and physiological functions of the two organs. The brain is composed of a variety of functional structures built...

Drug metabolic stability in early drug discovery to develop potential lead compounds.

Drug metabolism reviews

Gajula SNR, Nadimpalli N, Sonti R.
PMID: 34406889
Drug Metab Rev. 2021 Aug;53(3):459-477. doi: 10.1080/03602532.2021.1970178. Epub 2021 Sep 11.

Knowledge of the metabolic stability of a new drug substance eliminated by biotransformation is essential for envisaging the pharmacokinetic parameters required for deciding drug dosing and frequency. Strategies aimed at modifying lead compounds may improve metabolic stability, thereby reducing...

Correction.

Drug metabolism reviews

[No authors listed]
PMID: 33781132
Drug Metab Rev. 2021 Feb;53(1):I-VI. doi: 10.1080/03602532.2021.1907078. Epub 2021 Mar 29.

No abstract available.

Rodent genetic models of Ah receptor signaling.

Drug metabolism reviews

Wilson RH, Bradfield CA.
PMID: 34289754
Drug Metab Rev. 2021 Aug;53(3):350-374. doi: 10.1080/03602532.2021.1955916. Epub 2021 Aug 25.

The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the PER-ARNT-SIM superfamily of environmental sensors. This receptor has been a molecule of interest for many years in the field of toxicology, as...

Abstracts from the 10th North American ISSX Meeting.

Drug metabolism reviews

[No authors listed]
PMID: 28256160
Drug Metab Rev. 2000 Dec;32:vi-340. doi: 10.1080/03602532.2000.11864616.

No abstract available.

Showing 37 to 48 of 56 entries