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Showing 25 to 36 of 5708 entries
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Injectable therapy for Peyronie's disease.

Translational andrology and urology

Chong W, Tan RB.
PMID: 27298778
Transl Androl Urol. 2016 Jun;5(3):310-7. doi: 10.21037/tau.2016.03.15.

Peyronie's disease is a disfiguring and psychologically devastating disease, which continues to pose a significant clinical conundrum to the attending doctor. Many forms of therapy have been trialled but results have been inconsistent at best. Non-surgical therapy revolves around...

A phase II clinical trial of palonosetron for the management of delayed vomiting in gynecological cancer patients receiving paclitaxel/carboplatin therapy.

Molecular and clinical oncology

Takatori E, Shoji T, Miura Y, Nagao M, Takada A, Nagasawa T, Omi H, Kagabu M, Honda T, Sugiyama T.
PMID: 25798254
Mol Clin Oncol. 2015 Mar;3(2):281-286. doi: 10.3892/mco.2015.484. Epub 2015 Jan 09.

There are currently no studies demonstrating the effects of palonosetron on delayed chemotherapy-induced nausea and vomiting (CINV) in gynecological cancer patients receiving chemotherapy with moderately emetogenic chemotherapeutic agents. We conducted a phase II clinical trial to assess the efficacy...

One mechanism of glucocorticoid action in asthma may involve the inhibition of IL-25 expression.

Experimental and therapeutic medicine

Lu W, Lu C, Zhang C, Zhang C.
PMID: 28352347
Exp Ther Med. 2017 Feb;13(2):657-661. doi: 10.3892/etm.2016.4002. Epub 2016 Dec 27.

While the mechanism of action of classic cytokines in asthma has received increased attention from researchers, certain non-classical cytokines, such as IL-25, also participate in this mechanism. The present study was performed to investigate the changes in IL-25 (IL-17E)...

Maytansinoid immunoconjugate IMGN901 is cytotoxic in a three-dimensional culture model of multiple myeloma.

American journal of blood research

Nierste BA, Gunn EJ, Whiteman KR, Lutz RJ, Kirshner J.
PMID: 27335686
Am J Blood Res. 2016 May 18;6(1):6-18. eCollection 2016.

Environmental-mediated drug-resistance (EM-DR) presents a major challenge for therapeutic development. Tissue microenvironment in the form of extracellular matrix, soluble factors, and stroma contribute to EM-DR. In multiple myeloma (MM), drug-resistance has hindered treatment success with 5-year survival rates remaining

GDP versus ESHAP Regimen in Relapsed and/or Refractory Hodgkin lymphoma: A Comparison Study.

International journal of hematology-oncology and stem cell research

Ramzi M, Rezvani A, Dehghani M.
PMID: 25802695
Int J Hematol Oncol Stem Cell Res. 2015 Jan 01;9(1):10-4.

BACKGROUND: Despite multiple published studies reporting result of salvage regimens for relapsed and refractory Hodgkin's lymphoma, there are no comparisons of different combinations.PATIENTS AND METHODS: A Total of 44 patients identified with refractory or relapsed Hodgkin's Lymphoma were considered...

The Effect of a Combination Treatment Using Palonosetron, Promethazine, and Dexamethasone on the Prophylaxis of Postoperative Nausea and Vomiting and QTc Interval Duration in Patients Undergoing Craniotomy under General Anesthesia: A Pilot Study.

Frontiers in medicine

Bergese SD, Puente EG, Antor MA, Capo G, Yildiz VO, Uribe AA.
PMID: 26870733
Front Med (Lausanne). 2016 Feb 02;3:1. doi: 10.3389/fmed.2016.00001. eCollection 2016.

INTRODUCTION: Postoperative nausea and vomiting (PONV) is a displeasing experience that distresses surgical patients during the first 24 h after a surgical procedure. The incidence of postoperative nausea occurs in about 50%, the incidence of postoperative vomiting is about...

Impaired Spinal Glucocorticoid Receptor Signaling Contributes to the Attenuating Effect of Depression on Mechanical Allodynia and Thermal Hyperalgesia in Rats with Neuropathic Pain.

Frontiers in cellular neuroscience

Wei X, Sun Y, Luo F.
PMID: 28579944
Front Cell Neurosci. 2017 May 19;11:145. doi: 10.3389/fncel.2017.00145. eCollection 2017.

Although depression-induced altered pain perception has been described in several laboratory and clinical studies, its neurobiological mechanism in the central nervous system (CNS), particularly in the spinal dorsal horn, remains unclear. Therefore, in this study, we aimed to clarify...

Emphysematous Pyelonephritis and Cystitis: Unusual Adverse Events during Concurrent Chemoradiotherapy for Lung Cancer.

Case reports in oncology

Yokoyama T, Shinozaki S, Arimura H, Nakatomi K, Wataya H.
PMID: 28638336
Case Rep Oncol. 2017 Mar 09;10(1):239-243. doi: 10.1159/000463381. eCollection 2017.

Various adverse events can occur during antineoplastic therapy. A 67-year-old diabetic woman developed an emphysematous urinary tract infection (UTI) associated with chemoradiotherapy for lung cancer. She had received weekly carboplatin plus paclitaxel with thoracic radiotherapy and developed a fever...

MicroRNA-130b attenuates dexamethasone-induced increase of lipid accumulation in porcine preadipocytes by suppressing PPAR-γ expression.

Oncotarget

Pan S, Cui Y, Dong X, Zhang T, Xing H.
PMID: 29152131
Oncotarget. 2017 Sep 27;8(50):87928-87943. doi: 10.18632/oncotarget.21318. eCollection 2017 Oct 20.

In this study, two experiments were conducted to determine the role of miR-130b in dexamethasone (DEX)-induced lipid accumulation. Porcine preadipocytes were treated with 10

Overactivated autophagy contributes to steroid-induced avascular necrosis of the femoral head.

Experimental and therapeutic medicine

Li X, Li YS, Li LJ, Xie X, Yang Y, Deng ZH, Zeng C, Lei GH.
PMID: 28672940
Exp Ther Med. 2017 Jul;14(1):367-372. doi: 10.3892/etm.2017.4508. Epub 2017 May 23.

Steroid-induced avascular necrosis of the femoral head (SANFH) is a mainly bilateral complication of steroid therapy that involves extensive necrosis, and frequently occurs in young and middle-aged individuals, with a high disability rate. Autophagy is an intracellular lysosomal degradation...

Bosutinib as a fourth-line therapy for a patient with T315I-positive lymphoid blastic phase chronic myeloid leukemia: A case report.

Oncology letters

Komeno Y, Uchida N, Satoh Y, Uryu H, Iwata Y, Masuda A, Iihara K, Yatomi Y, Taniguchi S, Ryu T.
PMID: 28599428
Oncol Lett. 2017 Jun;13(6):4285-4289. doi: 10.3892/ol.2017.5989. Epub 2017 Apr 05.

A 35-year-old male was diagnosed with chronic myeloid leukemia in the chronic phase and was prescribed 100 mg daily dasatinib. However, dasatinib was discontinued due to thrombocytopenia, and within six months, the disease progressed to the lymphoid blastic phase....

Curculigoside regulates proliferation, differentiation, and pro-inflammatory cytokines levels in dexamethasone-induced rat calvarial osteoblasts.

International journal of clinical and experimental medicine

Zhu FB, Wang JY, Zhang YL, Quan RF, Yue ZS, Zeng LR, Zheng WJ, Hou Q, Yan SG, Hu YG.
PMID: 26550143
Int J Clin Exp Med. 2015 Aug 15;8(8):12337-46. eCollection 2015.

BACKGROUND: Curculigoside (CCG), one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn., is reported to prevent bone loss in ovariectomized rats. However, the underlying molecular mechanisms are largely unknown. Therefore, we investigated the...

Showing 25 to 36 of 5708 entries