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Showing 25 to 36 of 317 entries
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The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases.

Frontiers in pharmacology

Rižner TL.
PMID: 26924986
Front Pharmacol. 2016 Feb 18;7:30. doi: 10.3389/fphar.2016.00030. eCollection 2016.

Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women. These diseases are estrogen dependent, and their progression often depends on local estrogen formation. In...

Evaluating sex hormone levels in reproductive age women with multiple sclerosis and their relationship with disease severity.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Foroughipour A, Norbakhsh V, Najafabadi SH, Meamar R.
PMID: 23826018
J Res Med Sci. 2012 Sep;17(9):882-5.

BACKGROUND: Sex-related differences in the severity of multiple sclerosis (MS) could be influenced by the sex hormones.MATERIALS AND METHODS: This cohort (historical) study evaluated the sex hormone levels during menstrual cycle and their correlation with disease severity in MS.RESULT:...

Association between Body Mass Index and Serum Dehydroepiandrosterone Sulfate Level in 8-Year-Old Girls.

Journal of obesity & metabolic syndrome

Na JH, Kim YH, Hong SJ, Kim JK.
PMID: 31089550
J Obes Metab Syndr. 2018 Jun 30;27(2):110-116. doi: 10.7570/jomes.2018.27.2.110.

BACKGROUND: Adiposity may play a role as a potential trigger for adrenarche. The purpose of this study was to evaluate the association between body mass index (BMI) and serum dehydroepiandrosterone sulfate (DHEAS) level.METHODS: The medical records of 8-year-old girls...

[Dehydroepiandrosterone: physiological role and possibilities of use as a drug].

Problemy endokrinologii

Rozhivanov PV, Vaks VV.
PMID: 31627556
Probl Endokrinol (Mosk). 2005 Apr 15;51(2):46-51. doi: 10.14341/probl200551246-51.

Dehydroepiandrosterone (DHEA) is one of the important androgens synthesized by the adrenal cortex from 17-hydroxypregnenolone. In the mesh zone of the adrenal cortex, with the participation of enzymes 17, 20-desmolase and 17-a-hydroxylase, the cholesterol is sequentially converted through 17-hydroxypregnenolone...

[The specific features of adrenal steroidogenesis in patients with congenital adrenal cortical dysfunction due to 21-hydroxylase deficiency].

Problemy endokrinologii

Serebryakova IP, Velikanova LI, Vorokhobina NV, Silnitskiy PA, Strelnikova EG.
PMID: 31627545
Probl Endokrinol (Mosk). 2005 Aug 15;51(4):22-26. doi: 10.14341/probl200551422-26.

Forty-two patients with classical forms of congenital adrenal cortical dysfunction (CACD) (22 patients with salt-loosing form and 20 patients with simple virile form) caused by 21-hydroxylase deficiency and 29 female with an obscure form of the disease were examined....

Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study.

Journal of the Endocrine Society

Jiménez MC, Tucker KL, Rodriguez F, Porneala BC, Meigs JB, López L.
PMID: 30623167
J Endocr Soc. 2018 Dec 03;3(1):291-303. doi: 10.1210/js.2018-00205. eCollection 2019 Jan 01.

Low blood dehydroepiandrosterone sulfate (DHEAS) levels have strong positive associations with stroke and coronary heart disease. However, it is unclear whether DHEAS is independently associated with cardiovascular risk factors. Therefore, we examined the association between cardiovascular risk factors and...

Relationship of dehydroepiandrosterone sulfate levels with atherosclerosis in patients with subclinical hypothyroidism.

Wiener klinische Wochenschrift

Gonulalan G, Tanrıkulu Y.
PMID: 33788012
Wien Klin Wochenschr. 2021 Mar 31; doi: 10.1007/s00508-021-01844-9. Epub 2021 Mar 31.

BACKGROUND: Subclinical hypothyroidism is related with increased risk of cardiovascular diseases. The decreased levels of dehydroepiandrosterone sulphate (DHEA-S) are associated with hyperlipidemia, atherosclerosis and obesity. The lower levels of DHEA‑S might be an important factor in development of atherosclerosis...

The impact of rosuvastatin on hypothalamic-pituitary-testicular axis activity in metformin-treated and metformin-naïve men with low testosterone levels: a pilot study.

Pharmacological reports : PR

Krysiak R, Basiak M, Szkróbka W, Okopień B.
PMID: 34086261
Pharmacol Rep. 2021 Oct;73(5):1465-1472. doi: 10.1007/s43440-021-00289-1. Epub 2021 Jun 04.

BACKGROUND: Intense statin therapy was found to impair testosterone production in men. Metformin administered to subjects with hypergonadotropic hypogonadism decreased gonadotropin production. The current study was aimed at investigating whether metformin treatment modulates the impact of high-dose rosuvastatin therapy...

Cerebral perfusion in depression: Relationship to sex, dehydroepiandrosterone sulfate and depression severity.

NeuroImage. Clinical

Ritter C, Buchmann A, Müller ST, Hersberger M, Haynes M, Ghisleni C, Tuura R, Hasler G.
PMID: 34628302
Neuroimage Clin. 2021;32:102840. doi: 10.1016/j.nicl.2021.102840. Epub 2021 Sep 28.

BACKGROUND: Major depressive disorder (MDD) is a leading cause of disease burden and shows a marked sexual dimorphism. Previous studies reported changes in cerebral perfusion in MDD, an association between perfusion and dehydroepiandrosterone sulfate (DHEAS) levels, and large sex...

Rare Coexistence of Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency and Turner Syndrome: A Case Report and Brief Literature Review.

Journal of clinical research in pediatric endocrinology

Inácio I, Serra-Caetano J, Cardoso R, Dinis I, Mirante A.
PMID: 34355878
J Clin Res Pediatr Endocrinol. 2021 Aug 06; doi: 10.4274/jcrpe.galenos.2021.2021.0174. Epub 2021 Aug 06.

Coexistence of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency and Turner Syndrome (TS) is rare. We report a 6-year-old Portuguese girl with mosaic TS [45,XO(39)/47,XXX(21)] presented with premature pubarche at the age of 5 years. Laboratory findings showed...

Nonseminomatous Germ-Cell Tumor Presenting as Bilateral Adrenal Masses.

AACE clinical case reports

Baral N, Bansal R, Basyal B, Lee W, Kulkarni K, Kantorovich V, Sharma M.
PMID: 33851019
AACE Clin Case Rep. 2020 Dec 28;7(1):43-46. doi: 10.1016/j.aace.2020.11.011. eCollection 2021.

OBJECTIVE: Many tumors can metastasize to the adrenal glands, making the diagnosis of adrenal masses challenging. Awareness that rare primary tumors can metastasize to the adrenals and consideration of biopsy for their diagnosis, sometimes at extra-adrenal sites, is essential...

Functional characterization of Clonorchis sinensis sodium-bile acid co-transporter (CsSBAT) as a steroid sulfate transporter.

Parasitology research

Jung H, Won JY, Park YK, Han JH, Cha SH.
PMID: 34825261
Parasitol Res. 2021 Nov 26; doi: 10.1007/s00436-021-07393-4. Epub 2021 Nov 26.

Clonorchis sinensis (Cs) is a common trematode in Asian countries. Infection by Cs can result in many clinical symptoms. Here, a cDNA encoding a Cs apical sodium-dependent bile acid transporter (CsSBAT) was isolated from a Cs cDNA library, and...

Showing 25 to 36 of 317 entries