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Showing 313 to 317 of 317 entries
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Functional characterization of Clonorchis sinensis sodium-bile acid co-transporter (CsSBAT) as a steroid sulfate transporter.

Parasitology research

Jung H, Won JY, Park YK, Han JH, Cha SH.
PMID: 34825261
Parasitol Res. 2022 Jan;121(1):217-224. doi: 10.1007/s00436-021-07393-4. Epub 2021 Nov 26.

Clonorchis sinensis (Cs) is a common trematode in Asian countries. Infection by Cs can result in many clinical symptoms. Here, a cDNA encoding a Cs apical sodium-dependent bile acid transporter (CsSBAT) was isolated from a Cs cDNA library, and...

Diagnostic Accuracy of Dehydroepiandrosterone Sulfate and Corticotropin in Autonomous Cortisol Secretion.

Biomedicines

Carafone LE, Zhang CD, Li D, Lazik N, Hamidi O, Hurtado MD, Young WF, Thomas MA, Dy BM, Lyden ML, Foster TR, McKenzie TJ, Bancos I.
PMID: 34203283
Biomedicines. 2021 Jun 28;9(7). doi: 10.3390/biomedicines9070741.

Autonomous cortisol secretion (ACS) affects up to 50% of patients with adrenal adenomas. Despite the limited evidence, clinical guidelines recommend measurement of serum concentrations of dehydroepiandrosterone-sulfate (DHEA-S) and corticotropin (ACTH) to aid in the diagnosis of ACS. Our objective...

A Prospective Study of the Relationship Between Clinical Outcomes After Enzalutamide and Serum Androgen Levels Measured via Liquid Chromatography-tandem Mass Spectrometry in Patients with Castration-resistant Prostate Cancer.

European urology open science

Miyazawa Y, Sekine Y, Arai S, Nakamura T, Takezawa Y, Shimizu N, Matsuo Y, Ogura H, Takei T, Suzuki K.
PMID: 34337535
Eur Urol Open Sci. 2021 Jun 07;29:59-67. doi: 10.1016/j.euros.2021.05.003. eCollection 2021 Jul.

BACKGROUND: Enzalutamide (ENZ) is used to treat patients with castration-resistant prostate cancer (CRPC). However, the kinetics of serum androgens before and after ENZ treatment are unknown.OBJECTIVE: To elucidate the kinetics of serum androgens and explore the possibility of identifying...

Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study.

Neurobiology of stress

Jenz ST, Goodyear CD, TSgt Graves PR, Goldstein S, Shia MR, Redei EE.
PMID: 33912629
Neurobiol Stress. 2021 Apr 09;14:100323. doi: 10.1016/j.ynstr.2021.100323. eCollection 2021 May.

In highly stressful environments, individuals with diverging stress-reactivity can perform differently. Identification of blood markers of stress-reactivity is of major significance to help human performance during stress. Candidate transcripts were identified between stressed and non-stressed strains of rats' blood...

Fenfluramine modulates the anti-amnesic effects induced by sigma-1 receptor agonists and neuro(active)steroids in vivo.

Epilepsy & behavior : E&B

Martin P, Maurice T, Gammaitoni A, Farfel G, Boyd B, Galer B.
PMID: 35007961
Epilepsy Behav. 2022 Jan 07;127:108526. doi: 10.1016/j.yebeh.2021.108526. Epub 2022 Jan 07.

Fenfluramine (N-ethyl-α-methl-3-(trifluoromethyl)phenethylamine) is an anti-seizure medication (ASM) particularly effective in patients with Dravet syndrome, a severe treatment-resistant epileptic encephalopathy. Fenfluramine acts not only as neuronal serotonin (5-HT) releaser but also as a positive modulator of the sigma-1 receptor (S1R)....

Showing 313 to 317 of 317 entries