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The development of anthracycline analogs (review).

International journal of oncology

Vasey P.
PMID: 21573611
Int J Oncol. 1993 Apr;2(4):677-81. doi: 10.3892/ijo.2.4.677.

The anthracycline class of antitumour agents have the widest spectrum of activity of all drugs used to treat malignant disease. Consequently they are ubiquitous in their use worldwide, but are not without problems. The abrogation of cardiac toxicity and...

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Vasey P. The development of anthracycline analogs (review). Int J Oncol. 1993;2(4):677-81doi: 10.3892/ijo.2.4.677.
Vasey, P. (1993). The development of anthracycline analogs (review). International journal of oncology, 2(4), 677-81. https://doi.org/10.3892/ijo.2.4.677
Vasey, P. "The development of anthracycline analogs (review)." International journal of oncology vol. 2,4 (1993): 677-81. doi: https://doi.org/10.3892/ijo.2.4.677
Vasey P. The development of anthracycline analogs (review). Int J Oncol. 1993 Apr;2(4):677-81. doi: 10.3892/ijo.2.4.677. PMID: 21573611.
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Clinical Significance of ALK-1 Gene Abnormalities in Diffuse Large Cell Lymphoma.

Clinical Medicine Insights. Oncology

Korashy L, El-Zawahry H, Abdou S, Shahin D, Sherif F, Farrag W, Abdel-Khalik O, Salem H, El-Sebaaie A.
PMID: 23239932
Clin Med Insights Oncol. 2012;6:395-405. doi: 10.4137/CMO.S9920. Epub 2012 Nov 26.

OBJECTIVES: To detect relative frequency of anaplastic lymphoma kinase (ALK-1) gene abnormality in diffuse large cell lymphoma (DLCL) using fluorescence in situ hybridization (FISH), and correlate its presence with clinicopathological features which may be useful for choice of therapy...

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Korashy L, El-Zawahry H, Abdou S, et al. Clinical Significance of ALK-1 Gene Abnormalities in Diffuse Large Cell Lymphoma. Clin Med Insights Oncol. 2012;6:395-405doi: 10.4137/CMO.S9920.
Korashy, L., El-Zawahry, H., Abdou, S., Shahin, D., Sherif, F., Farrag, W., Abdel-Khalik, O., Salem, H., & El-Sebaaie, A. (2012). Clinical Significance of ALK-1 Gene Abnormalities in Diffuse Large Cell Lymphoma. Clinical Medicine Insights. Oncology, 6395-405. https://doi.org/10.4137/CMO.S9920
Korashy, L, et al. "Clinical Significance of ALK-1 Gene Abnormalities in Diffuse Large Cell Lymphoma." Clinical Medicine Insights. Oncology vol. 6 (2012): 395-405. doi: https://doi.org/10.4137/CMO.S9920
Korashy L, El-Zawahry H, Abdou S, Shahin D, Sherif F, Farrag W, Abdel-Khalik O, Salem H, El-Sebaaie A. Clinical Significance of ALK-1 Gene Abnormalities in Diffuse Large Cell Lymphoma. Clin Med Insights Oncol. 2012;6:395-405. doi: 10.4137/CMO.S9920. Epub 2012 Nov 26. PMID: 23239932; PMCID: PMC3516130.
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Adenovirus-mediated delivery of the human IFN-γ gene potentiates the cytotoxicity of daunorubicin against leukemic cells through downregulation of the α4β1 integrin/ILK/apoptosis pathway.

Oncology letters

Zhang J, Wang H, Wang L, Wang WD, Geng QR, Lu Y.
PMID: 24396448
Oncol Lett. 2014 Feb;7(2):361-368. doi: 10.3892/ol.2013.1749. Epub 2013 Dec 10.

The recurrence of acute myeloid leukemia (AML) is primarily attributed to drug resistance and minimal residual disease. In addition, adhesion of hematopoietic tumor cells to bone marrow extracellular matrix via β1 integrins (α4β1 and α5β1) is crucial in this...

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Zhang J, Wang H, Wang L, et al. Adenovirus-mediated delivery of the human IFN-γ gene potentiates the cytotoxicity of daunorubicin against leukemic cells through downregulation of the α4β1 integrin/ILK/apoptosis pathway. Oncol Lett. 2013;7(2):361-368doi: 10.3892/ol.2013.1749.
Zhang, J., Wang, H., Wang, L., Wang, W. D., Geng, Q. R., & Lu, Y. (2014). Adenovirus-mediated delivery of the human IFN-γ gene potentiates the cytotoxicity of daunorubicin against leukemic cells through downregulation of the α4β1 integrin/ILK/apoptosis pathway. Oncology letters, 7(2), 361-368. https://doi.org/10.3892/ol.2013.1749
Zhang, Jing, et al. "Adenovirus-mediated delivery of the human IFN-γ gene potentiates the cytotoxicity of daunorubicin against leukemic cells through downregulation of the α4β1 integrin/ILK/apoptosis pathway." Oncology letters vol. 7,2 (2014): 361-368. doi: https://doi.org/10.3892/ol.2013.1749
Zhang J, Wang H, Wang L, Wang WD, Geng QR, Lu Y. Adenovirus-mediated delivery of the human IFN-γ gene potentiates the cytotoxicity of daunorubicin against leukemic cells through downregulation of the α4β1 integrin/ILK/apoptosis pathway. Oncol Lett. 2014 Feb;7(2):361-368. doi: 10.3892/ol.2013.1749. Epub 2013 Dec 10. PMID: 24396448; PMCID: PMC3881933.
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Use of pluronic micelles to overcome multidrug-resistance.

International journal of oncology

Paradis R, Noel C, Page M.
PMID: 21559714
Int J Oncol. 1994 Dec;5(6):1305-8. doi: 10.3892/ijo.5.6.1305.

Pluronic P-85 (poly(55)(oxypropylene)dipoly(s)(oxyethylene)) was used to form daunorubicin containing micelles. This new carrier was tested in vitro on sensitive and resistant ovarian cancer cell lines. Drug incorporation was measured by cytofluorometry and the cytotoxicity was measured by the tetrazolium...

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Paradis R, Noel C, Page M. Use of pluronic micelles to overcome multidrug-resistance. Int J Oncol. 1994;5(6):1305-8doi: 10.3892/ijo.5.6.1305.
Paradis, R., Noel, C., & Page, M. (1994). Use of pluronic micelles to overcome multidrug-resistance. International journal of oncology, 5(6), 1305-8. https://doi.org/10.3892/ijo.5.6.1305
Paradis, R, et al. "Use of pluronic micelles to overcome multidrug-resistance." International journal of oncology vol. 5,6 (1994): 1305-8. doi: https://doi.org/10.3892/ijo.5.6.1305
Paradis R, Noel C, Page M. Use of pluronic micelles to overcome multidrug-resistance. Int J Oncol. 1994 Dec;5(6):1305-8. doi: 10.3892/ijo.5.6.1305. PMID: 21559714.
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Intrinsic cytotoxicity and reversal of multidrug-resistance by monensin in kb parent and mdr cells.

International journal of oncology

Ling Y, Priebe W, Perezsoler R.
PMID: 21573461
Int J Oncol. 1993 Nov;3(5):971-7. doi: 10.3892/ijo.3.5.971.

Results presented in this study indicate that monensin, a Na+/H+ gradient ionophore, is by itself a potent inhibitor of proliferation of both KB parent and KB/multidrug resistant (MDR) cells. By MTT assay, the ID50 of monensin against both cell...

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Ling Y, Priebe W, Perezsoler R. Intrinsic cytotoxicity and reversal of multidrug-resistance by monensin in kb parent and mdr cells. Int J Oncol. 1993;3(5):971-7doi: 10.3892/ijo.3.5.971.
Ling, Y., Priebe, W., & Perezsoler, R. (1993). Intrinsic cytotoxicity and reversal of multidrug-resistance by monensin in kb parent and mdr cells. International journal of oncology, 3(5), 971-7. https://doi.org/10.3892/ijo.3.5.971
Ling, Y, et al. "Intrinsic cytotoxicity and reversal of multidrug-resistance by monensin in kb parent and mdr cells." International journal of oncology vol. 3,5 (1993): 971-7. doi: https://doi.org/10.3892/ijo.3.5.971
Ling Y, Priebe W, Perezsoler R. Intrinsic cytotoxicity and reversal of multidrug-resistance by monensin in kb parent and mdr cells. Int J Oncol. 1993 Nov;3(5):971-7. doi: 10.3892/ijo.3.5.971. PMID: 21573461.
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Comparative embryotoxicity of four anthracyclines: In Vitro study on their effects on glutathione status.

Toxicology in vitro : an international journal published in association with BIBRA

Menegola E, Broccia ML, Prati M, Ricolfi R, Giavini E.
PMID: 20654294
Toxicol In Vitro. 1997 Feb-Apr;11(1):33-41. doi: 10.1016/s0887-2333(96)00070-7.

The embryotoxicity of four different anthracyclines [doxorubicin (DOXO), epirubicin (EPI), daunorubicin (DAUNO) and idarubicin (IDA)] was compared using the postimplantation whole embryo culture method. Moreover, to investigate the role of free oxygen radical production in anthracycline-induced embryotoxicity, the reduced...

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Menegola E, Broccia ML, Prati M, et al. Comparative embryotoxicity of four anthracyclines: In Vitro study on their effects on glutathione status. Toxicol In Vitro. 1997;11(1):33-41doi: 10.1016/s0887-2333(96)00070-7.
Menegola, E., Broccia, M. L., Prati, M., Ricolfi, R., & Giavini, E. (1997). Comparative embryotoxicity of four anthracyclines: In Vitro study on their effects on glutathione status. Toxicology in vitro : an international journal published in association with BIBRA, 11(1), 33-41. https://doi.org/10.1016/s0887-2333(96)00070-7
Menegola, E, et al. "Comparative embryotoxicity of four anthracyclines: In Vitro study on their effects on glutathione status." Toxicology in vitro : an international journal published in association with BIBRA vol. 11,1 (1997): 33-41. doi: https://doi.org/10.1016/s0887-2333(96)00070-7
Menegola E, Broccia ML, Prati M, Ricolfi R, Giavini E. Comparative embryotoxicity of four anthracyclines: In Vitro study on their effects on glutathione status. Toxicol In Vitro. 1997 Feb-Apr;11(1):33-41. doi: 10.1016/s0887-2333(96)00070-7. PMID: 20654294.
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Significant dose Escalation of Idarubicin in the treatment of aggressive Non- Hodgkin Lymphoma leads to increased hematotoxicity without improvement in efficacy in comparison to standard CHOEP-14: 9-year follow up results of the CIVEP trial of the DSHNHL.

SpringerPlus

Hohloch K, Zwick C, Ziepert M, Hasenclever D, Kaiser U, Engert A, Höffkes HG, Kroschinsky F, Mesters R, Feller AC, Löffler M, Trümper L, Pfreundschuh M.
PMID: 24455463
Springerplus. 2014 Jan 03;3:5. doi: 10.1186/2193-1801-3-5. eCollection 2014 Jan 03.

BACKGROUND: Dose escalation and modification of CHOP has improved the prognosis of patients with aggressive lymphoma; even in the rituximab era, dose escalation for high-risk patients is exploited and frequently limited by drug toxicity. Idarubicin (Id) is a 4-demethoxy...

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Hohloch K, Zwick C, Ziepert M, et al. Significant dose Escalation of Idarubicin in the treatment of aggressive Non- Hodgkin Lymphoma leads to increased hematotoxicity without improvement in efficacy in comparison to standard CHOEP-14: 9-year follow up results of the CIVEP trial of the DSHNHL. Springerplus. 2014;3:5doi: 10.1186/2193-1801-3-5.
Hohloch, K., Zwick, C., Ziepert, M., Hasenclever, D., Kaiser, U., Engert, A., Höffkes, H. G., Kroschinsky, F., Mesters, R., Feller, A. C., Löffler, M., Trümper, L., Pfreundschuh, M. (2014). Significant dose Escalation of Idarubicin in the treatment of aggressive Non- Hodgkin Lymphoma leads to increased hematotoxicity without improvement in efficacy in comparison to standard CHOEP-14: 9-year follow up results of the CIVEP trial of the DSHNHL. SpringerPlus, 35. https://doi.org/10.1186/2193-1801-3-5
Hohloch, Karin, et al. "Significant dose Escalation of Idarubicin in the treatment of aggressive Non- Hodgkin Lymphoma leads to increased hematotoxicity without improvement in efficacy in comparison to standard CHOEP-14: 9-year follow up results of the CIVEP trial of the DSHNHL." SpringerPlus vol. 3 (2014): 5. doi: https://doi.org/10.1186/2193-1801-3-5
Hohloch K, Zwick C, Ziepert M, Hasenclever D, Kaiser U, Engert A, Höffkes HG, Kroschinsky F, Mesters R, Feller AC, Löffler M, Trümper L, Pfreundschuh M. Significant dose Escalation of Idarubicin in the treatment of aggressive Non- Hodgkin Lymphoma leads to increased hematotoxicity without improvement in efficacy in comparison to standard CHOEP-14: 9-year follow up results of the CIVEP trial of the DSHNHL. Springerplus. 2014 Jan 03;3:5. doi: 10.1186/2193-1801-3-5. eCollection 2014 Jan 03. PMID: 24455463; PMCID: PMC3890437.
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The promotion of secondary structures in single-stranded DNA by drugs that bind to duplex DNA: an atomic force microscopy study.

Nanotechnology

Adamcik J, Valle F, Witz G, Rechendorff K, Dietler G.
PMID: 21832575
Nanotechnology. 2008 Sep 24;19(38):384016. doi: 10.1088/0957-4484/19/38/384016. Epub 2008 Aug 12.

We study the behavior of single-stranded DNA (ssDNA) in the presence of well-known drugs with either an intercalating binding mode, such as daunorubicin, actinomycin D, and chloroquine, or a minor groove binding mode, such as netropsin and berenil, by...

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Adamcik J, Valle F, Witz G, et al. The promotion of secondary structures in single-stranded DNA by drugs that bind to duplex DNA: an atomic force microscopy study. Nanotechnology. 2008;19(38):384016doi: 10.1088/0957-4484/19/38/384016.
Adamcik, J., Valle, F., Witz, G., Rechendorff, K., & Dietler, G. (2008). The promotion of secondary structures in single-stranded DNA by drugs that bind to duplex DNA: an atomic force microscopy study. Nanotechnology, 19(38), 384016. https://doi.org/10.1088/0957-4484/19/38/384016
Adamcik, Jozef, et al. "The promotion of secondary structures in single-stranded DNA by drugs that bind to duplex DNA: an atomic force microscopy study." Nanotechnology vol. 19,38 (2008): 384016. doi: https://doi.org/10.1088/0957-4484/19/38/384016
Adamcik J, Valle F, Witz G, Rechendorff K, Dietler G. The promotion of secondary structures in single-stranded DNA by drugs that bind to duplex DNA: an atomic force microscopy study. Nanotechnology. 2008 Sep 24;19(38):384016. doi: 10.1088/0957-4484/19/38/384016. Epub 2008 Aug 12. PMID: 21832575.
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Recent advances in the treatment of acute myeloid leukemia.

F1000 medicine reports

Abdel-Wahab O, Levine RL.
PMID: 20798782
F1000 Med Rep. 2010 Jul 22;2:55. doi: 10.3410/M2-55.

Acute myeloid leukemia (AML) is a disorder with significant molecular and clinical heterogeneity. Although there have been clear advances in the identification of somatic genetic and epigenetic alterations present in the malignant cells of patients with AML, translating this...

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Abdel-Wahab O, Levine RL. Recent advances in the treatment of acute myeloid leukemia. F1000 Med Rep. 2010;2:55doi: 10.3410/M2-55.
Abdel-Wahab, O., & Levine, R. L. (2010). Recent advances in the treatment of acute myeloid leukemia. F1000 medicine reports, 255. https://doi.org/10.3410/M2-55
Abdel-Wahab, Omar, and Levine, Ross L. "Recent advances in the treatment of acute myeloid leukemia." F1000 medicine reports vol. 2 (2010): 55. doi: https://doi.org/10.3410/M2-55
Abdel-Wahab O, Levine RL. Recent advances in the treatment of acute myeloid leukemia. F1000 Med Rep. 2010 Jul 22;2:55. doi: 10.3410/M2-55. PMID: 20798782; PMCID: PMC2927833.
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Reversal of multidrug resistance by the anti-malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line.

Oncology letters

Liu L, Zuo LF, Guo JW.
PMID: 24179544
Oncol Lett. 2013 Nov;6(5):1475-1481. doi: 10.3892/ol.2013.1545. Epub 2013 Aug 23.

The overexpression of ATP-binding cassette (ABC) transporters confers multidrug resistance (MDR) to tumor cells. ABCG2 is a member of the ABC superfamily. The present study aimed to investigate the correlation between ABCG2 expression and the MDR of esophageal cancer...

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Liu L, Zuo LF, Guo JW. Reversal of multidrug resistance by the anti-malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line. Oncol Lett. 2013;6(5):1475-1481doi: 10.3892/ol.2013.1545.
Liu, L., Zuo, L. F., & Guo, J. W. (2013). Reversal of multidrug resistance by the anti-malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line. Oncology letters, 6(5), 1475-1481. https://doi.org/10.3892/ol.2013.1545
Liu, Liang, et al. "Reversal of multidrug resistance by the anti-malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line." Oncology letters vol. 6,5 (2013): 1475-1481. doi: https://doi.org/10.3892/ol.2013.1545
Liu L, Zuo LF, Guo JW. Reversal of multidrug resistance by the anti-malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line. Oncol Lett. 2013 Nov;6(5):1475-1481. doi: 10.3892/ol.2013.1545. Epub 2013 Aug 23. PMID: 24179544; PMCID: PMC3813605.
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Sabarubicin.

Topics in current chemistry

Arcamone FM.
PMID: 23605632
Top Curr Chem. 2008;283:171-89. doi: 10.1007/128_2007_1.

Disaccharide derivatives in the daunorubicin and in the 4-demethoxy (idarubicin) series in whichthe first sugar moiety linked to the aglycone is a non-aminated sugar, namely 2-deoxy-L-rhamnose or 2-deoxy-L-fucose andthe second moiety is daunosamine, have been obtained upon synthesis of...

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Arcamone FM. Sabarubicin. Top Curr Chem. 2008;283:171-89doi: 10.1007/128_2007_1.
Arcamone, F. M. (2008). Sabarubicin. Topics in current chemistry, 283171-89. https://doi.org/10.1007/128_2007_1
Arcamone, Federico-Maria. "Sabarubicin." Topics in current chemistry vol. 283 (2008): 171-89. doi: https://doi.org/10.1007/128_2007_1
Arcamone FM. Sabarubicin. Top Curr Chem. 2008;283:171-89. doi: 10.1007/128_2007_1. PMID: 23605632.
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Acute promyelocytic leukemia presenting as an extradural mass.

Revista brasileira de hematologia e hemoterapia

Bittencourt H, Teixeira Junior AL, Glória AB, Ribeiro AF, Fagundes EM.
PMID: 23049367
Rev Bras Hematol Hemoter. 2011;33(6):478-80. doi: 10.5581/1516-8484.20110126.

Acute promyelocytic leukemia is potentially a highly curable type of leukemia that usually presents with pancytopenia, coagulopathies and bleeding. We describe a case of an unusual presentation of acute promyelocytic leukemia. A 53 year-old male was admitted complaining of...

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Bittencourt H, Teixeira Junior AL, Glória AB, et al. Acute promyelocytic leukemia presenting as an extradural mass. Rev Bras Hematol Hemoter. 2011;33(6):478-80doi: 10.5581/1516-8484.20110126.
Bittencourt, H., Teixeira Junior, A. L., Glória, A. B., Ribeiro, A. F., & Fagundes, E. M. (2011). Acute promyelocytic leukemia presenting as an extradural mass. Revista brasileira de hematologia e hemoterapia, 33(6), 478-80. https://doi.org/10.5581/1516-8484.20110126
Bittencourt, Henrique, et al. "Acute promyelocytic leukemia presenting as an extradural mass." Revista brasileira de hematologia e hemoterapia vol. 33,6 (2011): 478-80. doi: https://doi.org/10.5581/1516-8484.20110126
Bittencourt H, Teixeira Junior AL, Glória AB, Ribeiro AF, Fagundes EM. Acute promyelocytic leukemia presenting as an extradural mass. Rev Bras Hematol Hemoter. 2011;33(6):478-80. doi: 10.5581/1516-8484.20110126. PMID: 23049367; PMCID: PMC3459371.
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Showing 13 to 24 of 337 entries