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Showing 25 to 36 of 313 entries
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Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease.

Frontiers in cellular neuroscience

Vejar S, Oyarzún JE, Retamal MA, Ortiz FC, Orellana JA.
PMID: 30760982
Front Cell Neurosci. 2019 Jan 29;13:3. doi: 10.3389/fncel.2019.00003. eCollection 2019.

Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper synaptic...

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Vejar S, Oyarzún JE, Retamal MA, et al. Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease. Front Cell Neurosci. 2019;13:3doi: 10.3389/fncel.2019.00003.
Vejar, S., Oyarzún, J. E., Retamal, M. A., Ortiz, F. C., & Orellana, J. A. (2019). Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease. Frontiers in cellular neuroscience, 133. https://doi.org/10.3389/fncel.2019.00003
Vejar, Sebastián, et al. "Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease." Frontiers in cellular neuroscience vol. 13 (2019): 3. doi: https://doi.org/10.3389/fncel.2019.00003
Vejar S, Oyarzún JE, Retamal MA, Ortiz FC, Orellana JA. Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease. Front Cell Neurosci. 2019 Jan 29;13:3. doi: 10.3389/fncel.2019.00003. eCollection 2019. PMID: 30760982; PMCID: PMC6361860.
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Diseases associated with leaky hemichannels.

Frontiers in cellular neuroscience

Retamal MA, Reyes EP, García IE, Pinto B, Martínez AD, González C.
PMID: 26283912
Front Cell Neurosci. 2015 Jul 27;9:267. doi: 10.3389/fncel.2015.00267. eCollection 2015.

Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication. While HCs connect the intracellular compartment with the extracellular milieu, GJCs allow the interchange of molecules between cytoplasm of...

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Retamal MA, Reyes EP, García IE, et al. Diseases associated with leaky hemichannels. Front Cell Neurosci. 2015;9:267doi: 10.3389/fncel.2015.00267.
Retamal, M. A., Reyes, E. P., García, I. E., Pinto, B., Martínez, A. D., & González, C. (2015). Diseases associated with leaky hemichannels. Frontiers in cellular neuroscience, 9267. https://doi.org/10.3389/fncel.2015.00267
Retamal, Mauricio A, et al. "Diseases associated with leaky hemichannels." Frontiers in cellular neuroscience vol. 9 (2015): 267. doi: https://doi.org/10.3389/fncel.2015.00267
Retamal MA, Reyes EP, García IE, Pinto B, Martínez AD, González C. Diseases associated with leaky hemichannels. Front Cell Neurosci. 2015 Jul 27;9:267. doi: 10.3389/fncel.2015.00267. eCollection 2015. PMID: 26283912; PMCID: PMC4515567.
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Vitamin C and Microvascular Dysfunction in Systemic Inflammation.

Antioxidants (Basel, Switzerland)

Tyml K.
PMID: 28661424
Antioxidants (Basel). 2017 Jun 29;6(3). doi: 10.3390/antiox6030049.

Sepsis, life-threatening organ dysfunction caused by a dysfunctional host response to infection, is associated with high mortality. A promising strategy to improve the outcome is to inject patients intravenously with ascorbate (vitamin C). In animal models of sepsis, this...

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Tyml K. Vitamin C and Microvascular Dysfunction in Systemic Inflammation. Antioxidants (Basel). 2017;6(3)doi: 10.3390/antiox6030049.
Tyml, K. (2017). Vitamin C and Microvascular Dysfunction in Systemic Inflammation. Antioxidants (Basel, Switzerland), 6(3), . https://doi.org/10.3390/antiox6030049
Tyml, Karel. "Vitamin C and Microvascular Dysfunction in Systemic Inflammation." Antioxidants (Basel, Switzerland) vol. 6,3 (2017). doi: https://doi.org/10.3390/antiox6030049
Tyml K. Vitamin C and Microvascular Dysfunction in Systemic Inflammation. Antioxidants (Basel). 2017 Jun 29;6(3). doi: 10.3390/antiox6030049. PMID: 28661424; PMCID: PMC5618077.
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Managing the complexity of communication: regulation of gap junctions by post-translational modification.

Frontiers in pharmacology

Axelsen LN, Calloe K, Holstein-Rathlou NH, Nielsen MS.
PMID: 24155720
Front Pharmacol. 2013 Oct 22;4:130. doi: 10.3389/fphar.2013.00130.

Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of...

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Axelsen LN, Calloe K, Holstein-Rathlou NH, et al. Managing the complexity of communication: regulation of gap junctions by post-translational modification. Front Pharmacol. 2013;4:130doi: 10.3389/fphar.2013.00130.
Axelsen, L. N., Calloe, K., Holstein-Rathlou, N. H., & Nielsen, M. S. (2013). Managing the complexity of communication: regulation of gap junctions by post-translational modification. Frontiers in pharmacology, 4130. https://doi.org/10.3389/fphar.2013.00130
Axelsen, Lene N, et al. "Managing the complexity of communication: regulation of gap junctions by post-translational modification." Frontiers in pharmacology vol. 4 (2013): 130. doi: https://doi.org/10.3389/fphar.2013.00130
Axelsen LN, Calloe K, Holstein-Rathlou NH, Nielsen MS. Managing the complexity of communication: regulation of gap junctions by post-translational modification. Front Pharmacol. 2013 Oct 22;4:130. doi: 10.3389/fphar.2013.00130. PMID: 24155720; PMCID: PMC3804956.
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Connexins and Nitric Oxide Inside and Outside Mitochondria: Significance for Cardiac Protection and Adaptation.

Frontiers in physiology

Shvedova M, Anfinogenova Y, Popov SV, Atochin DN.
PMID: 29867537
Front Physiol. 2018 May 16;9:479. doi: 10.3389/fphys.2018.00479. eCollection 2018.

Irreversible myocardial damage happens in the presence of prolonged and severe ischemia. Several phenomena protect the heart against myocardial infarction and other adverse outcomes of ischemia and reperfusion (IR), namely: hibernation related to stunned myocardium, ischemic preconditioning (IPC), ischemic...

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Shvedova M, Anfinogenova Y, Popov SV, et al. Connexins and Nitric Oxide Inside and Outside Mitochondria: Significance for Cardiac Protection and Adaptation. Front Physiol. 2018;9:479doi: 10.3389/fphys.2018.00479.
Shvedova, M., Anfinogenova, Y., Popov, S. V., & Atochin, D. N. (2018). Connexins and Nitric Oxide Inside and Outside Mitochondria: Significance for Cardiac Protection and Adaptation. Frontiers in physiology, 9479. https://doi.org/10.3389/fphys.2018.00479
Shvedova, Maria, et al. "Connexins and Nitric Oxide Inside and Outside Mitochondria: Significance for Cardiac Protection and Adaptation." Frontiers in physiology vol. 9 (2018): 479. doi: https://doi.org/10.3389/fphys.2018.00479
Shvedova M, Anfinogenova Y, Popov SV, Atochin DN. Connexins and Nitric Oxide Inside and Outside Mitochondria: Significance for Cardiac Protection and Adaptation. Front Physiol. 2018 May 16;9:479. doi: 10.3389/fphys.2018.00479. eCollection 2018. PMID: 29867537; PMCID: PMC5964197.
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Bioelectrical signals improve cardiac function and modify gene expression of extracellular matrix components.

ESC heart failure

Macfelda K, Kapeller B, Holly A, Podesser BK, Losert U, Brandes K, Goettel P, Mueller J.
PMID: 28772035
ESC Heart Fail. 2017 Aug;4(3):291-300. doi: 10.1002/ehf2.12169. Epub 2017 Jun 30.

AIMS: Beyond the influence of stimulating devices on cardiac excitation, their use in treating patients with heart failure has positive effects on the myocardium at the molecular level. Electrical signals can induce a wide spectrum of effects in living...

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Macfelda K, Kapeller B, Holly A, et al. Bioelectrical signals improve cardiac function and modify gene expression of extracellular matrix components. ESC Heart Fail. 2017;4(3):291-300doi: 10.1002/ehf2.12169.
Macfelda, K., Kapeller, B., Holly, A., Podesser, B. K., Losert, U., Brandes, K., Goettel, P., & Mueller, J. (2017). Bioelectrical signals improve cardiac function and modify gene expression of extracellular matrix components. ESC heart failure, 4(3), 291-300. https://doi.org/10.1002/ehf2.12169
Macfelda, Karin, et al. "Bioelectrical signals improve cardiac function and modify gene expression of extracellular matrix components." ESC heart failure vol. 4,3 (2017): 291-300. doi: https://doi.org/10.1002/ehf2.12169
Macfelda K, Kapeller B, Holly A, Podesser BK, Losert U, Brandes K, Goettel P, Mueller J. Bioelectrical signals improve cardiac function and modify gene expression of extracellular matrix components. ESC Heart Fail. 2017 Aug;4(3):291-300. doi: 10.1002/ehf2.12169. Epub 2017 Jun 30. PMID: 28772035; PMCID: PMC5542736.
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Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer's Disease.

Frontiers in neuroscience

Droguerre M, Duchêne A, Picoli C, Portal B, Lejards C, Guiard BP, Meunier J, Villard V, Déglon N, Hamon M, Mouthon F, Charvériat M.
PMID: 32612499
Front Neurosci. 2020 Jun 16;14:563. doi: 10.3389/fnins.2020.00563. eCollection 2020.

Donepezil (DPZ) is an acetylcholinesterase inhibitor used in Alzheimer's disease to restore cognitive functions but is endowed with limited efficacy. Recent studies pointed out the implication of astroglial networks in cognitive processes, notably via astrocyte connexins (Cxs), proteins involved...

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Droguerre M, Duchêne A, Picoli C, et al. Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer's Disease. Front Neurosci. 2020;14:563doi: 10.3389/fnins.2020.00563.
Droguerre, M., Duchêne, A., Picoli, C., Portal, B., Lejards, C., Guiard, B. P., Meunier, J., Villard, V., Déglon, N., Hamon, M., Mouthon, F., & Charvériat, M. (2020). Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer's Disease. Frontiers in neuroscience, 14563. https://doi.org/10.3389/fnins.2020.00563
Droguerre, Marine, et al. "Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer's Disease." Frontiers in neuroscience vol. 14 (2020): 563. doi: https://doi.org/10.3389/fnins.2020.00563
Droguerre M, Duchêne A, Picoli C, Portal B, Lejards C, Guiard BP, Meunier J, Villard V, Déglon N, Hamon M, Mouthon F, Charvériat M. Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer's Disease. Front Neurosci. 2020 Jun 16;14:563. doi: 10.3389/fnins.2020.00563. eCollection 2020. PMID: 32612499; PMCID: PMC7309601.
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Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization.

Frontiers in cellular neuroscience

Gómez GI, Falcon RV, Maturana CJ, Labra VC, Salgado N, Rojas CA, Oyarzun JE, Cerpa W, Quintanilla RA, Orellana JA.
PMID: 30564103
Front Cell Neurosci. 2018 Dec 04;12:472. doi: 10.3389/fncel.2018.00472. eCollection 2018.

A mounting body of evidence indicates that adolescents are specially more susceptible to alcohol influence than adults. However, the mechanisms underlying this phenomenon remain poorly understood. Astrocyte-mediated gliotransmission is crucial for hippocampal plasticity and recently, the opening of hemichannels...

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Gómez GI, Falcon RV, Maturana CJ, et al. Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization. Front Cell Neurosci. 2018;12:472doi: 10.3389/fncel.2018.00472.
Gómez, G. I., Falcon, R. V., Maturana, C. J., Labra, V. C., Salgado, N., Rojas, C. A., Oyarzun, J. E., Cerpa, W., Quintanilla, R. A., & Orellana, J. A. (2018). Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization. Frontiers in cellular neuroscience, 12472. https://doi.org/10.3389/fncel.2018.00472
Gómez, Gonzalo I, et al. "Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization." Frontiers in cellular neuroscience vol. 12 (2018): 472. doi: https://doi.org/10.3389/fncel.2018.00472
Gómez GI, Falcon RV, Maturana CJ, Labra VC, Salgado N, Rojas CA, Oyarzun JE, Cerpa W, Quintanilla RA, Orellana JA. Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization. Front Cell Neurosci. 2018 Dec 04;12:472. doi: 10.3389/fncel.2018.00472. eCollection 2018. PMID: 30564103; PMCID: PMC6288256.
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Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice.

Pain

Letellier B, Kremer M, Becker LJ, Andry V, Goumon Y, Leboulleux Q, Hener P, Inquimbert P, Couqueberg N, Waltisperger E, Yalcin I, Mouthon F, Droguerre M, Charvériat M, Barrot M.
PMID: 33769363
Pain. 2021 Dec 01;162(12):2841-2853. doi: 10.1097/j.pain.0000000000002276.

ABSTRACT: Tricyclic antidepressants that inhibit serotonin and noradrenaline reuptake, such as amitriptyline, are among the first-line treatments for neuropathic pain, which is caused by a lesion or disease affecting the somatosensory nervous system. These treatments are, however, partially efficient...

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Letellier B, Kremer M, Becker LJ, et al. Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice. Pain. 2021;162(12):2841-2853doi: 10.1097/j.pain.0000000000002276.
Letellier, B., Kremer, M., Becker, L. J., Andry, V., Goumon, Y., Leboulleux, Q., Hener, P., Inquimbert, P., Couqueberg, N., Waltisperger, E., Yalcin, I., Mouthon, F., Droguerre, M., Charvériat, M., & Barrot, M. (2021). Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice. Pain, 162(12), 2841-2853. https://doi.org/10.1097/j.pain.0000000000002276
Letellier, Baptiste, et al. "Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice." Pain vol. 162,12 (2021): 2841-2853. doi: https://doi.org/10.1097/j.pain.0000000000002276
Letellier B, Kremer M, Becker LJ, Andry V, Goumon Y, Leboulleux Q, Hener P, Inquimbert P, Couqueberg N, Waltisperger E, Yalcin I, Mouthon F, Droguerre M, Charvériat M, Barrot M. Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice. Pain. 2021 Dec 01;162(12):2841-2853. doi: 10.1097/j.pain.0000000000002276. PMID: 33769363; PMCID: PMC8600545.
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Inhibition of connexin 43 induces hearing loss in postnatal mice.

Physiology international

Wang J, Song Q.
PMID: 33769954
Physiol Int. 2021 Mar 26; doi: 10.1556/2060.2021.00008. Epub 2021 Mar 26.

BACKGROUND: Connexin 43 (Cx43) is the most ubiquitously expressed member of the family of connexins, constituting gap junctions and mediating cell communication, still its role in hearing loss has been little studied.METHODS: Immunohistochemistry was used to detect the expression...

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Wang J, Song Q. Inhibition of connexin 43 induces hearing loss in postnatal mice. Physiol Int. 2021;doi: 10.1556/2060.2021.00008.
Wang, J., & Song, Q. (2021). Inhibition of connexin 43 induces hearing loss in postnatal mice. Physiology international, . https://doi.org/10.1556/2060.2021.00008
Wang, J, and Song, Q. "Inhibition of connexin 43 induces hearing loss in postnatal mice." Physiology international vol. (2021). doi: https://doi.org/10.1556/2060.2021.00008
Wang J, Song Q. Inhibition of connexin 43 induces hearing loss in postnatal mice. Physiol Int. 2021 Mar 26; doi: 10.1556/2060.2021.00008. Epub 2021 Mar 26. PMID: 33769954.
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Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice.

Frontiers in cellular neuroscience

Cibelli A, Veronica Lopez-Quintero S, Mccutcheon S, Scemes E, Spray DC, Stout RF, Suadicani SO, Thi MM, Urban-Maldonado M.
PMID: 33790744
Front Cell Neurosci. 2021 Mar 15;15:647109. doi: 10.3389/fncel.2021.647109. eCollection 2021.

We transduced mouse cortical astrocytes cultured from four litters of embryonic wildtype (WT) and connexin43 (Cx43) null mouse pups with lentiviral vector encoding hTERT and measured expression of astrocyte-specific markers up to passage 10 (p10). The immortalized cell lines...

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Cibelli A, Veronica Lopez-Quintero S, Mccutcheon S, et al. Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice. Front Cell Neurosci. 2021;15:647109doi: 10.3389/fncel.2021.647109.
Cibelli, A., Veronica Lopez-Quintero, S., Mccutcheon, S., Scemes, E., Spray, D. C., Stout, R. F., Suadicani, S. O., Thi, M. M., & Urban-Maldonado, M. (2021). Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice. Frontiers in cellular neuroscience, 15647109. https://doi.org/10.3389/fncel.2021.647109
Cibelli, Antonio, et al. "Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice." Frontiers in cellular neuroscience vol. 15 (2021): 647109. doi: https://doi.org/10.3389/fncel.2021.647109
Cibelli A, Veronica Lopez-Quintero S, Mccutcheon S, Scemes E, Spray DC, Stout RF, Suadicani SO, Thi MM, Urban-Maldonado M. Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice. Front Cell Neurosci. 2021 Mar 15;15:647109. doi: 10.3389/fncel.2021.647109. eCollection 2021. PMID: 33790744; PMCID: PMC8005635.
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Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity.

Frontiers in molecular neuroscience

Brunal AA, Clark KC, Ma M, Woods IG, Pan YA.
PMID: 33505244
Front Mol Neurosci. 2021 Jan 11;13:587978. doi: 10.3389/fnmol.2020.587978. eCollection 2020.

Connexins are transmembrane proteins that form hemichannels allowing the exchange of molecules between the extracellular space and the cell interior. Two hemichannels from adjacent cells dock and form a continuous gap junction pore, thereby permitting direct intercellular communication. Connexin...

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Brunal AA, Clark KC, Ma M, et al. Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity. Front Mol Neurosci. 2021;13:587978doi: 10.3389/fnmol.2020.587978.
Brunal, A. A., Clark, K. C., Ma, M., Woods, I. G., & Pan, Y. A. (2020). Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity. Frontiers in molecular neuroscience, 13587978. https://doi.org/10.3389/fnmol.2020.587978
Brunal, Alyssa A, et al. "Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity." Frontiers in molecular neuroscience vol. 13 (2020): 587978. doi: https://doi.org/10.3389/fnmol.2020.587978
Brunal AA, Clark KC, Ma M, Woods IG, Pan YA. Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity. Front Mol Neurosci. 2021 Jan 11;13:587978. doi: 10.3389/fnmol.2020.587978. eCollection 2020. PMID: 33505244; PMCID: PMC7829467.
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Showing 25 to 36 of 313 entries