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Showing 25 to 36 of 1369 entries
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FMF Genotype-phenotype correlation in Iranian Azeri Turks: Association between M694V/R761H mutation and amyloidosis.

Iranian journal of basic medical sciences

Bonyadi MJ, Somi MH, Khoshknab MM, Eslami F, Montazam M, Gerami SM.
PMID: 26351556
Iran J Basic Med Sci. 2015 Jul;18(7):659-63.

OBJECTIVES: Familial Mediterranean fever (FMF), an inherited autosomal recessive disorder, is frequently present among individuals of Mediterranean origin. Differences in the clinical manifestations of FMF between different ethnic groups have been documented. The aim of the present study was...

New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.

ACS medicinal chemistry letters

Thomopoulou P, Sachs J, Teusch N, Mariappan A, Gopalakrishnan J, Schmalz HG.
PMID: 26985296
ACS Med Chem Lett. 2015 Dec 29;7(2):188-91. doi: 10.1021/acsmedchemlett.5b00418. eCollection 2016 Feb 11.

A series of new colchicinoids with a variable triazole unit at C-7 was synthesized through Cu(I)-catalyzed 1,3-dipolar cycloaddition (click-chemistry) of a colchicine-derived azide with various alkynes and the cytotoxicity against THP-1 and Jurkat cancer cell lines was used for...

[The effect of Colchicine on the differentiation and the frequency of transdetermination in leg imaginal disks ofDrosophila melanogaster].

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen

Tobler H.
PMID: 28304687
Wilhelm Roux Arch Entwickl Mech Org. 1970 Sep;165(3):217-225. doi: 10.1007/BF01380785.

1. Treatment of male foreleg disks of late 3rd instar larvae ofDrosophila melanogaster with Colchicinein vitro (Conc. 0.005-1 mg/ml) and implantation into larval hosts of the same age results in the formation of a characteristic pattern of damage, whereby...

Insect epidermis: disturbance of supracellular tissue polarity does not prevent the expression of cell polarity.

Roux's archives of developmental biology : the official organ of the EDBO

Nübler-Jung K.
PMID: 28305549
Rouxs Arch Dev Biol. 1987 Jul;196(5):286-289. doi: 10.1007/BF00395951.

The insect integument displays planar tissue polarity in the uniform orientation of polarized cuticular structures. In a body segment, for example, the denticles and bristles produced by the constituent epidermal cells point posteriorly. Colchicine can abolish this uniform orientation...

Polar effects of concanavalin A on the cortical cytoskeleton of a molluscan egg (Nassarius reticulatus, Gastropoda).

Roux's archives of developmental biology : the official organ of the EDBO

Speksnijder JE, Teerds KJ, Hage WJ, Dohmen MR.
PMID: 28305913
Rouxs Arch Dev Biol. 1991 Jun;200(1):8-20. doi: 10.1007/BF02457636.

The organization of the surface of fertilizedNassarius reticulatus eggs was probed by investigating the effects of treatment with concanavalin A (Con A). This lectin causes abnormal polar lobe formation as well as inhibition of cleavage. At low concentrations of...

A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos.

Roux's archives of developmental biology : the official organ of the EDBO

Bodmer R, Jan LY, Jan YN.
PMID: 28306050
Rouxs Arch Dev Biol. 1993 Aug;202(6):371-381. doi: 10.1007/BF00188736.

In Drosophila, mutations in a class of genes, the neurogenic genes, produce an excess of neurons. This neural hyperplasia has been attributed to the formation of more than the normal number of neuronal precursor cells at the expense of...

Colchicine-induced myoneuropathy in a cyclosporine-treated renal transplant recipient.

Kidney research and clinical practice

Huh K, Joung JY, Jeong H, Je D, Cho YY, Jang HR, Huh W.
PMID: 26877917
Kidney Res Clin Pract. 2013 Jun;32(2):74-7. doi: 10.1016/j.krcp.2013.04.003. Epub 2013 May 23.

Colchicine is a relatively safe medication that is widely used for both prevention and treatment of gout attack. However, serious adverse events, including myoneuropathy and multiorgan failure, have been reported. We report a case of colchicine-induced myoneuropathy in a...

Fever of unknown origin in a haemodialysis patient: a late diagnosis requiring a novel treatment.

Clinical kidney journal

Pateinakis P, Katsaounou C, Meimaridou D, Manou E, Papadopoulou D, Tsakiris DJ.
PMID: 25852898
Clin Kidney J. 2014 Jun;7(3):314-7. doi: 10.1093/ckj/sfu044. Epub 2014 May 14.

No abstract available.

Effects of colchicine on pericardial diseases: a review of the literature and current evidence.

Journal of community hospital internal medicine perspectives

Shah SR, Alweis R, Shah SA, Arshad MH, Manji AA, Arfeen AA, Javed M, Shujauddin SM, Irfan R, Shabbir S, Shaikh S.
PMID: 27406462
J Community Hosp Intern Med Perspect. 2016 Jul 06;6(3):31957. doi: 10.3402/jchimp.v6.31957. eCollection 2016.

Colchicine, extracted from the colchicum autumnale plant, used by the ancient Greeks more than 20 centuries ago, is one of the most ancient drugs still prescribed even today. The major mechanism of action is binding to microtubules thereby interfering...

The Ku70 DNA-repair protein is involved in centromere function in a grasshopper species.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

Cabrero J, Bakkali M, Navarro-Domínguez B, Ruíz-Ruano FJ, Martín-Blázquez R, López-León MD, Camacho JP.
PMID: 23797468
Chromosome Res. 2013 Jun 25; doi: 10.1007/s10577-013-9367-7. Epub 2013 Jun 25.

The Ku70 protein is involved in numerous cell functions, the nonhomologous end joining (NHEJ) DNA repair pathway being the best known. Here, we report a novel function for this protein in the grasshopper Eyprepocnemis plorans. We observed the presence...

Familial mediterranean Fever: diagnosing as early as 3 months of age.

Case reports in pediatrics

Keskindemirci G, Aktay Ayaz N, Aldemir E, Aydoğmuş C, Aydoğan G, Kavuncuoğlu S.
PMID: 24800095
Case Rep Pediatr. 2014;2014:296479. doi: 10.1155/2014/296479. Epub 2014 Mar 27.

Familial Mediterranean Fever is an autosomal recessive disease. Major symptoms of disease are recurrent fever accompanied by serositis attacks. The disease is usually diagnosed before 20 years of age. Symptoms related to FMF are noted when children become more...

Successful crosses between fungal-resistant wild species of Arachis (section Arachis) and Arachis hypogaea.

Genetics and molecular biology

Fávero AP, Dos Santos RF, Simpson CE, Valls JF, Vello NA.
PMID: 26500440
Genet Mol Biol. 2015 Jul-Sep;38(3):353-65. doi: 10.1590/S1415-475738320140376. Epub 2015 Aug 21.

Peanut (Arachis hypogaea) is the fifth most produced oil crop worldwide. Besides lack of water, fungal diseases are the most limiting factors for the crop. Several species of Arachis are resistant to certain pests and diseases. This study aimed...

Showing 25 to 36 of 1369 entries