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Showing 25 to 36 of 57184 entries
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Synovial tissue response to treatment in psoriatic arthritis.

The open rheumatology journal

Codullo V, McInnes IB.
PMID: 22279513
Open Rheumatol J. 2011;5:133-7. doi: 10.2174/1874312901105010133. Epub 2011 Dec 30.

Following its validation and wide application in rheumatoid arthritis (RA), synovial tissue analysis has recently been applied to studies on Psoriatic Arthritis (PsA). Such studies aim to thereby clarify its distinctive features and the nature of specific responses upon...

Use of mTOR inhibitors in the treatment of breast cancer: an evaluation of factors that influence patient outcomes.

Breast cancer (Dove Medical Press)

Jerusalem G, Rorive A, Collignon J.
PMID: 24833916
Breast Cancer (Dove Med Press). 2014 Apr 17;6:43-57. doi: 10.2147/BCTT.S38679. eCollection 2014.

Many systemic treatment options are available for advanced breast cancer, including endocrine therapy, chemotherapy, anti-human epidermal growth factor receptor 2 (HER2) therapy, and other targeted agents. Recently, everolimus, a mammalian target of rapamycin (mTOR) inhibitor, combined with exemestane, an...

Biomarkers in kidney transplantation: From bench to bedside.

World journal of nephrology

Townamchai N, Eiam-Ong S.
PMID: 26558185
World J Nephrol. 2015 Nov 06;4(5):487-91. doi: 10.5527/wjn.v4.i5.487.

Immunosuppressive drug level monitoring and serum creatinine are widely used for kidney transplantation (KT) monitoring. Monitoring of drug level is not the direct measurement of the immune response while the rising of creatinine is too late for detection of...

A Comparison Effect of Copper Nanoparticles versus Copper Sulphate on Juvenile Epinephelus coioides: Growth Parameters, Digestive Enzymes, Body Composition, and Histology as Biomarkers.

International journal of genomics

Wang T, Long X, Cheng Y, Liu Z, Yan S.
PMID: 26527479
Int J Genomics. 2015;2015:783021. doi: 10.1155/2015/783021. Epub 2015 Oct 07.

Copper nanoparticles (Cu-NPs) are components in numerous commercial products, but little is known about their potential hazard in the marine environments. In this study the effects of Cu-NPs and soluble Cu on juvenile Epinephelus coioides were investigated. The fish...

Breast Cancer Survival Defined by the ER/PR/HER2 Subtypes and a Surrogate Classification according to Tumor Grade and Immunohistochemical Biomarkers.

Journal of cancer epidemiology

Parise CA, Caggiano V.
PMID: 24955090
J Cancer Epidemiol. 2014;2014:469251. doi: 10.1155/2014/469251. Epub 2014 May 26.

Introduction. ER, PR, and HER2 are routinely available in breast cancer specimens. The purpose of this study is to contrast breast cancer-specific survival for the eight ER/PR/HER2 subtypes with survival of an immunohistochemical surrogate for the molecular subtype based...

Network-based biomarkers for cold coagulation blood stasis syndrome and the therapeutic effects of shaofu zhuyu decoction in rats.

Evidence-based complementary and alternative medicine : eCAM

Su S, Duan J, Cui W, Shang E, Liu P, Bai G, Guo S, Qian D, Tang Y.
PMID: 24288569
Evid Based Complement Alternat Med. 2013;2013:901943. doi: 10.1155/2013/901943. Epub 2013 Oct 21.

In this study, the reverse docking methodology was applied to predict the action targets and pathways of Shaofu Zhuyu decoction (SFZYD) bioactive ingredients. Furthermore, Traditional Chinese Medicine (TCM) cold coagulation blood stasis (CCBS) syndrome was induced in female Sprague-Dawley...

Potential impact of silymarin in combination with chlorogenic acid and/or melatonin in combating cardiomyopathy induced by carbon tetrachloride.

Saudi journal of biological sciences

Al-Rasheed NM, Al-Rasheed NM, Faddah LM, Mohamed AM, Mohammad RA, Al-Amin M.
PMID: 24955012
Saudi J Biol Sci. 2014 Jul;21(3):265-74. doi: 10.1016/j.sjbs.2013.09.006. Epub 2013 Sep 17.

The aim of this study was to investigate the effective role of silymarin either alone or in combination with chlorogenic acid and/or melatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction. CCl4 (l.2 ml/kg body weight)...

Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer.

OncoTargets and therapy

Wang Z, Wang Z, Liang Z, Liu J, Shi W, Bai P, Lin X, Magaye R, Zhao J.
PMID: 24204158
Onco Targets Ther. 2013 Oct 16;6:1437-44. doi: 10.2147/OTT.S51997. eCollection 2013.

The expression and clinical significance of insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), and insulin-like growth factor binding protein 7 (IGFBP-7) were investigated in serum and lung cancer tissues from 57 patients with non-small...

Sensitive Detection of Cardiac Biomarkers Using a Magnetic Microbead Immunoassay.

Analytical methods : advancing methods and applications

Woolley CF, Hayes MA.
PMID: 26527562
Anal Methods. 2015 Oct 21;7(20):8632-8639. doi: 10.1039/C5AY01071C. Epub 2015 Aug 20.

To achieve improved sensitivity in cardiac biomarker detection, a batch incubation magnetic microbead immunoassay was developed and tested on three separate human protein targets: myoglobin, heart-type fatty acid binding protein, and cardiac troponin I. A sandwich immunoassay was performed...

INCORPORATING BIOLOGICAL INFORMATION INTO LINEAR MODELS: A BAYESIAN APPROACH TO THE SELECTION OF PATHWAYS AND GENES.

The annals of applied statistics

Stingo FC, Chen YA, Tadesse MG, Vannucci M.
PMID: 23667412
Ann Appl Stat. 2011 Sep 01;5(3):1978-2002. doi: 10.1214/11-AOAS463.

The vast amount of biological knowledge accumulated over the years has allowed researchers to identify various biochemical interactions and define different families of pathways. There is an increased interest in identifying pathways and pathway elements involved in particular biological...

CSF p-Tau levels in the prediction of Alzheimer's disease.

Biology open

Kandimalla RJ, Prabhakar S, Wani WY, Kaushal A, Gupta N, Sharma DR, Grover VK, Bhardwaj N, Jain K, Gill KD.
PMID: 24244848
Biol Open. 2013 Sep 04;2(11):1119-24. doi: 10.1242/bio.20135447. eCollection 2013.

The two hallmarks of Alzheimer's disease (AD) are neurofibrillary tangles and amyloid plaques. Neurofibrillary tangles are formed due to the hyperphosphorylation of tau protein. There is an urgent need to develop a reliable biomarker for the diagnosis of AD....

Analyzing historical trends in breast cancer biomarker expression: a feasibility study (1947-2009).

NPJ breast cancer

Krieger N, Habel LA, Waterman PD, Shabani M, Ellison-Loschmann L, Achacoso NS, Acton L, Schnitt SJ.
PMID: 26807440
NPJ Breast Cancer. 2015;1. doi: 10.1038/npjbcancer.2015.16. Epub 2015 Oct 07.

BACKGROUND/OBJECTIVES: Determining long-term trends in tumor biomarker expression is essential for understanding aspects of tumor biology amenable to change. Limiting the availability of such data, currently used assays for biomarkers are relatively new. For example, assays for the estrogen...

Showing 25 to 36 of 57184 entries