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Non-β-blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma.

The Journal of clinical investigation

Seebauer CT, Graus MS, Huang L, McCann AJ, Wylie-Sears J, Fontaine FR, Karnezis T, Zurakowski D, Staffa SJ, Meunier FA, Mulliken JB, Bischoff J, Francois M.
PMID: 34874911
J Clin Invest. 2021 Dec 07; doi: 10.1172/JCI151109. Epub 2021 Dec 07.

Propranolol and atenolol, current therapies for problematic infantile hemangioma (IH), are composed of R(+) and S(-) enantiomers: the R(+) enantiomer is largely devoid of β-blocker activity. We investigated the effect of R(+) enantiomers of propranolol and atenolol on the...

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Seebauer CT, Graus MS, Huang L, et al. Non-β-blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma. J Clin Invest. 2021;doi: 10.1172/JCI151109.
Seebauer, C. T., Graus, M. S., Huang, L., McCann, A. J., Wylie-Sears, J., Fontaine, F. R., Karnezis, T., Zurakowski, D., Staffa, S. J., Meunier, F. A., Mulliken, J. B., Bischoff, J., & Francois, M. (2021). Non-β-blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma. The Journal of clinical investigation, . https://doi.org/10.1172/JCI151109
Seebauer, Caroline T, et al. "Non-β-blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma." The Journal of clinical investigation vol. (2021). doi: https://doi.org/10.1172/JCI151109
Seebauer CT, Graus MS, Huang L, McCann AJ, Wylie-Sears J, Fontaine FR, Karnezis T, Zurakowski D, Staffa SJ, Meunier FA, Mulliken JB, Bischoff J, Francois M. Non-β-blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma. J Clin Invest. 2021 Dec 07; doi: 10.1172/JCI151109. Epub 2021 Dec 07. PMID: 34874911.
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Nanomaterial Synthesis in Ionic Liquids and Their Use on the Photocatalytic Degradation of Emerging Pollutants.

Nanomaterials (Basel, Switzerland)

Corchero R, Rodil R, Soto A, Rodil E.
PMID: 33562868
Nanomaterials (Basel). 2021 Feb 05;11(2). doi: 10.3390/nano11020411.

The unique properties of ionic liquids make them suitable candidates to prepare nanoscale materials. A simple method that uses exclusively a corresponding bulk material and an ionic liquid-in this case, [P

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Corchero R, Rodil R, Soto A, et al. Nanomaterial Synthesis in Ionic Liquids and Their Use on the Photocatalytic Degradation of Emerging Pollutants. Nanomaterials (Basel). 2021;11(2)doi: 10.3390/nano11020411.
Corchero, R., Rodil, R., Soto, A., & Rodil, E. (2021). Nanomaterial Synthesis in Ionic Liquids and Their Use on the Photocatalytic Degradation of Emerging Pollutants. Nanomaterials (Basel, Switzerland), 11(2), . https://doi.org/10.3390/nano11020411
Corchero, Raquel, et al. "Nanomaterial Synthesis in Ionic Liquids and Their Use on the Photocatalytic Degradation of Emerging Pollutants." Nanomaterials (Basel, Switzerland) vol. 11,2 (2021). doi: https://doi.org/10.3390/nano11020411
Corchero R, Rodil R, Soto A, Rodil E. Nanomaterial Synthesis in Ionic Liquids and Their Use on the Photocatalytic Degradation of Emerging Pollutants. Nanomaterials (Basel). 2021 Feb 05;11(2). doi: 10.3390/nano11020411. PMID: 33562868; PMCID: PMC7916080.
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Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation.

PloS one

Khan A.
PMID: 34882723
PLoS One. 2021 Dec 09;16(12):e0261051. doi: 10.1371/journal.pone.0261051. eCollection 2021.

High shear wet granulation is commonly applied technique for commercial manufacturing of tablets. Granulation process for tablets manufacturing is generally optimized by hit and trial which involves preparation of granules under different processing parameters, compression of granules and evaluation...

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Khan A. Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation. PLoS One. 2021;16(12):e0261051doi: 10.1371/journal.pone.0261051.
Khan, A. (2021). Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation. PloS one, 16(12), e0261051. https://doi.org/10.1371/journal.pone.0261051
Khan, Amjad. "Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation." PloS one vol. 16,12 (2021): e0261051. doi: https://doi.org/10.1371/journal.pone.0261051
Khan A. Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation. PLoS One. 2021 Dec 09;16(12):e0261051. doi: 10.1371/journal.pone.0261051. eCollection 2021. PMID: 34882723; PMCID: PMC8660064.
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Enhanced Slow Sand Filtration for the Removal of Micropollutants from Groundwater.

The Science of the total environment

Vu CT, Wu T.
PMID: 34875329
Sci Total Environ. 2021 Dec 04;809:152161. doi: 10.1016/j.scitotenv.2021.152161. Epub 2021 Dec 04.

Remote areas, where centralized water supply cannot reach, rely heavily on decentralized supply systems such as slow sand filters (SSFs). Groundwater used to be a reliable water source; yet, the advent of micropollutants (MPs) has raised concerns over its...

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Vu CT, Wu T. Enhanced Slow Sand Filtration for the Removal of Micropollutants from Groundwater. Sci Total Environ. 2021;809:152161doi: 10.1016/j.scitotenv.2021.152161.
Vu, C. T., & Wu, T. (2021). Enhanced Slow Sand Filtration for the Removal of Micropollutants from Groundwater. The Science of the total environment, 809152161. https://doi.org/10.1016/j.scitotenv.2021.152161
Vu, Chi Thanh, and Wu, Tingting. "Enhanced Slow Sand Filtration for the Removal of Micropollutants from Groundwater." The Science of the total environment vol. 809 (2021): 152161. doi: https://doi.org/10.1016/j.scitotenv.2021.152161
Vu CT, Wu T. Enhanced Slow Sand Filtration for the Removal of Micropollutants from Groundwater. Sci Total Environ. 2021 Dec 04;809:152161. doi: 10.1016/j.scitotenv.2021.152161. Epub 2021 Dec 04. PMID: 34875329.
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Clozapine Induced Hypertension and its Association with Autonomic Dysfunction.

Psychopharmacology bulletin

Deepak MB, Deeksha K, Pallavi R, Hemant C, Nidhisha B, Raman D.
PMID: 34887604
Psychopharmacol Bull. 2021 Nov 03;51(4):122-127.

Clozapine is a second generation antipsychotic agent which is drug of choice for treatment resistant schizophrenia. Tachycardia and postural hypotension are most frequently observed cardiovascular adverse effects, but reports on new-onset persistently elevated blood pressure are sparse. Mechanisms underlying...

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Deepak MB, Deeksha K, Pallavi R, et al. Clozapine Induced Hypertension and its Association with Autonomic Dysfunction. Psychopharmacol Bull. 2021;51(4):122-127
Deepak, M. B., Deeksha, K., Pallavi, R., Hemant, C., Nidhisha, B., & Raman, D. (2021). Clozapine Induced Hypertension and its Association with Autonomic Dysfunction. Psychopharmacology bulletin, 51(4), 122-127.
Deepak, M B, et al. "Clozapine Induced Hypertension and its Association with Autonomic Dysfunction." Psychopharmacology bulletin vol. 51,4 (2021): 122-127.
Deepak MB, Deeksha K, Pallavi R, Hemant C, Nidhisha B, Raman D. Clozapine Induced Hypertension and its Association with Autonomic Dysfunction. Psychopharmacol Bull. 2021 Nov 03;51(4):122-127. PMID: 34887604; PMCID: PMC8601757.
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Novel pathway and acetate-facilitated complete atenolol degradation by Hydrogenophaga sp. YM1 isolated from activated sludge.

The Science of the total environment

Yi M, Sheng Q, Lv Z, Lu H.
PMID: 34890665
Sci Total Environ. 2021 Dec 07;810:152218. doi: 10.1016/j.scitotenv.2021.152218. Epub 2021 Dec 07.

Atenolol is a widely prescribed beta-blocker that has been detected in wastewater at concentrations up to 300 μg/L. The parent compound and its transformation products pose risks to aquatic organisms. Efficient atenolol degrading microorganism has yet to be identified,...

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Yi M, Sheng Q, Lv Z, et al. Novel pathway and acetate-facilitated complete atenolol degradation by Hydrogenophaga sp. YM1 isolated from activated sludge. Sci Total Environ. 2021;810:152218doi: 10.1016/j.scitotenv.2021.152218.
Yi, M., Sheng, Q., Lv, Z., & Lu, H. (2021). Novel pathway and acetate-facilitated complete atenolol degradation by Hydrogenophaga sp. YM1 isolated from activated sludge. The Science of the total environment, 810152218. https://doi.org/10.1016/j.scitotenv.2021.152218
Yi, Ming, et al. "Novel pathway and acetate-facilitated complete atenolol degradation by Hydrogenophaga sp. YM1 isolated from activated sludge." The Science of the total environment vol. 810 (2021): 152218. doi: https://doi.org/10.1016/j.scitotenv.2021.152218
Yi M, Sheng Q, Lv Z, Lu H. Novel pathway and acetate-facilitated complete atenolol degradation by Hydrogenophaga sp. YM1 isolated from activated sludge. Sci Total Environ. 2021 Dec 07;810:152218. doi: 10.1016/j.scitotenv.2021.152218. Epub 2021 Dec 07. PMID: 34890665.
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β-blocker eye drops affect ocular surface through β2 adrenoceptor of corneal limbal stem cells.

BMC ophthalmology

Yuan X, Ma X, Yang L, Zhou Q, Li Y.
PMID: 34863129
BMC Ophthalmol. 2021 Dec 05;21(1):419. doi: 10.1186/s12886-021-02186-w.

BACKGROUND: Topical application of β-blocker eye drops induces damage to the ocular surface in clinical. However, the mechanism involved remains incompletely understood. The purpose of this study was to investigate the influence and mechanism of β-blocker eye drops on...

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Yuan X, Ma X, Yang L, et al. β-blocker eye drops affect ocular surface through β2 adrenoceptor of corneal limbal stem cells. BMC Ophthalmol. 2021;21(1):419doi: 10.1186/s12886-021-02186-w.
Yuan, X., Ma, X., Yang, L., Zhou, Q., & Li, Y. (2021). β-blocker eye drops affect ocular surface through β2 adrenoceptor of corneal limbal stem cells. BMC ophthalmology, 21(1), 419. https://doi.org/10.1186/s12886-021-02186-w
Yuan, Xingyue, et al. "β-blocker eye drops affect ocular surface through β2 adrenoceptor of corneal limbal stem cells." BMC ophthalmology vol. 21,1 (2021): 419. doi: https://doi.org/10.1186/s12886-021-02186-w
Yuan X, Ma X, Yang L, Zhou Q, Li Y. β-blocker eye drops affect ocular surface through β2 adrenoceptor of corneal limbal stem cells. BMC Ophthalmol. 2021 Dec 05;21(1):419. doi: 10.1186/s12886-021-02186-w. PMID: 34863129; PMCID: PMC8645087.
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Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study.

Hypertension (Dallas, Tex. : 1979)

Chan You S, Krumholz HM, Suchard MA, Schuemie MJ, Hripcsak G, Chen R, Shea S, Duke J, Pratt N, Reich CG, Madigan D, Ryan PB, Woong Park R, Park S.
PMID: 33775125
Hypertension. 2021 May 05;77(5):1528-1538. doi: 10.1161/HYPERTENSIONAHA.120.16402. Epub 2021 Mar 29.

[Figure: see text].

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Chan You S, Krumholz HM, Suchard MA, et al. Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study. Hypertension. 2021;77(5):1528-1538doi: 10.1161/HYPERTENSIONAHA.120.16402.
Chan You, S., Krumholz, H. M., Suchard, M. A., Schuemie, M. J., Hripcsak, G., Chen, R., Shea, S., Duke, J., Pratt, N., Reich, C. G., Madigan, D., Ryan, P. B., Woong Park, R., & Park, S. (2021). Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study. Hypertension (Dallas, Tex. : 1979), 77(5), 1528-1538. https://doi.org/10.1161/HYPERTENSIONAHA.120.16402
Chan You, Seng, et al. "Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study." Hypertension (Dallas, Tex. : 1979) vol. 77,5 (2021): 1528-1538. doi: https://doi.org/10.1161/HYPERTENSIONAHA.120.16402
Chan You S, Krumholz HM, Suchard MA, Schuemie MJ, Hripcsak G, Chen R, Shea S, Duke J, Pratt N, Reich CG, Madigan D, Ryan PB, Woong Park R, Park S. Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study. Hypertension. 2021 May 05;77(5):1528-1538. doi: 10.1161/HYPERTENSIONAHA.120.16402. Epub 2021 Mar 29. PMID: 33775125; PMCID: PMC8035236.
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In silico design and pharmacological evaluation of conjugates of atenolol with modified saccharide for cardiovascular targeting.

Glycoconjugate journal

Kumbhar ST, Patil SS, Bhatia MS.
PMID: 33687640
Glycoconj J. 2021 Apr;38(2):261-271. doi: 10.1007/s10719-021-09983-x. Epub 2021 Mar 09.

Amongst a wide range of biological macromolecules, saccharides exhibit the potential to be specifically recognized by cell-surface receptors and hence can be utilized as ligands in targeted drug delivery. The current study aims to use saccharides viz. Galactose, Pectin...

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Kumbhar ST, Patil SS, Bhatia MS. In silico design and pharmacological evaluation of conjugates of atenolol with modified saccharide for cardiovascular targeting. Glycoconj J. 2021;38(2):261-271doi: 10.1007/s10719-021-09983-x.
Kumbhar, S. T., Patil, S. S., & Bhatia, M. S. (2021). In silico design and pharmacological evaluation of conjugates of atenolol with modified saccharide for cardiovascular targeting. Glycoconjugate journal, 38(2), 261-271. https://doi.org/10.1007/s10719-021-09983-x
Kumbhar, Smita Tukaram, et al. "In silico design and pharmacological evaluation of conjugates of atenolol with modified saccharide for cardiovascular targeting." Glycoconjugate journal vol. 38,2 (2021): 261-271. doi: https://doi.org/10.1007/s10719-021-09983-x
Kumbhar ST, Patil SS, Bhatia MS. In silico design and pharmacological evaluation of conjugates of atenolol with modified saccharide for cardiovascular targeting. Glycoconj J. 2021 Apr;38(2):261-271. doi: 10.1007/s10719-021-09983-x. Epub 2021 Mar 09. PMID: 33687640.
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Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

You ZB, Galaj E, Alén F, Wang B, Bi GH, Moore AR, Buck T, Crissman M, Pari S, Xi ZX, Leggio L, Wise RA, Gardner EL.
PMID: 34923576
Neuropsychopharmacology. 2021 Dec 18; doi: 10.1038/s41386-021-01249-2. Epub 2021 Dec 18.

Cocaine addiction is a significant medical and public concern. Despite decades of research effort, development of pharmacotherapy for cocaine use disorder remains largely unsuccessful. This may be partially due to insufficient understanding of the complex biological mechanisms involved in...

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You ZB, Galaj E, Alén F, et al. Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors. Neuropsychopharmacology. 2021;doi: 10.1038/s41386-021-01249-2.
You, Z. B., Galaj, E., Alén, F., Wang, B., Bi, G. H., Moore, A. R., Buck, T., Crissman, M., Pari, S., Xi, Z. X., Leggio, L., Wise, R. A., & Gardner, E. L. (2021). Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, . https://doi.org/10.1038/s41386-021-01249-2
You, Zhi-Bing, et al. "Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. (2021). doi: https://doi.org/10.1038/s41386-021-01249-2
You ZB, Galaj E, Alén F, Wang B, Bi GH, Moore AR, Buck T, Crissman M, Pari S, Xi ZX, Leggio L, Wise RA, Gardner EL. Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors. Neuropsychopharmacology. 2021 Dec 18; doi: 10.1038/s41386-021-01249-2. Epub 2021 Dec 18. PMID: 34923576.
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Enhanced Slow Sand Filtration for the Removal of Micropollutants from Groundwater.

The Science of the total environment

Vu CT, Wu T.
PMID: 34875329
Sci Total Environ. 2021 Dec 04;809:152161. doi: 10.1016/j.scitotenv.2021.152161. Epub 2021 Dec 04.

Remote areas, where centralized water supply cannot reach, rely heavily on decentralized supply systems such as slow sand filters (SSFs). Groundwater used to be a reliable water source; yet, the advent of micropollutants (MPs) has raised concerns over its...

Cite
Vu CT, Wu T. Enhanced Slow Sand Filtration for the Removal of Micropollutants from Groundwater. Sci Total Environ. 2021;809:152161doi: 10.1016/j.scitotenv.2021.152161.
Vu, C. T., & Wu, T. (2021). Enhanced Slow Sand Filtration for the Removal of Micropollutants from Groundwater. The Science of the total environment, 809152161. https://doi.org/10.1016/j.scitotenv.2021.152161
Vu, Chi Thanh, and Wu, Tingting. "Enhanced Slow Sand Filtration for the Removal of Micropollutants from Groundwater." The Science of the total environment vol. 809 (2021): 152161. doi: https://doi.org/10.1016/j.scitotenv.2021.152161
Vu CT, Wu T. Enhanced Slow Sand Filtration for the Removal of Micropollutants from Groundwater. Sci Total Environ. 2021 Dec 04;809:152161. doi: 10.1016/j.scitotenv.2021.152161. Epub 2021 Dec 04. PMID: 34875329.
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Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease.

Alzheimer's research & therapy

Fang J, Zhang P, Wang Q, Chiang CW, Zhou Y, Hou Y, Xu J, Chen R, Zhang B, Lewis SJ, Leverenz JB, Pieper AA, Li B, Li L, Cummings J, Cheng F.
PMID: 35012639
Alzheimers Res Ther. 2022 Jan 10;14(1):7. doi: 10.1186/s13195-021-00951-z.

BACKGROUND: Genome-wide association studies (GWAS) have identified numerous susceptibility loci for Alzheimer's disease (AD). However, utilizing GWAS and multi-omics data to identify high-confidence AD risk genes (ARGs) and druggable targets that can guide development of new therapeutics for patients...

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Fang J, Zhang P, Wang Q, et al. Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease. Alzheimers Res Ther. 2022;14(1):7doi: 10.1186/s13195-021-00951-z.
Fang, J., Zhang, P., Wang, Q., Chiang, C. W., Zhou, Y., Hou, Y., Xu, J., Chen, R., Zhang, B., Lewis, S. J., Leverenz, J. B., Pieper, A. A., Li, B., Li, L., Cummings, J., & Cheng, F. (2022). Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease. Alzheimer's research & therapy, 14(1), 7. https://doi.org/10.1186/s13195-021-00951-z
Fang, Jiansong, et al. "Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease." Alzheimer's research & therapy vol. 14,1 (2022): 7. doi: https://doi.org/10.1186/s13195-021-00951-z
Fang J, Zhang P, Wang Q, Chiang CW, Zhou Y, Hou Y, Xu J, Chen R, Zhang B, Lewis SJ, Leverenz JB, Pieper AA, Li B, Li L, Cummings J, Cheng F. Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease. Alzheimers Res Ther. 2022 Jan 10;14(1):7. doi: 10.1186/s13195-021-00951-z. PMID: 35012639; PMCID: PMC8751379.
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Showing 361 to 372 of 372 entries