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Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model.

Journal of ethnopharmacology

Xu Z, Lin S, Tong Z, Chen S, Cao Y, Li Q, Jiang Y, Cai W, Tong Y, Zahra BS, Wang P.
PMID: 34848360
J Ethnopharmacol. 2021 Nov 27;285:114873. doi: 10.1016/j.jep.2021.114873. Epub 2021 Nov 27.

ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine considers that the etiology and pathogenesis of non-alcoholic fatty liver disease (NAFLD) are related to liver depression and qi stagnation. Saffron and its active ingredient, crocetin (CCT), are used for the treatment of metabolic...

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Xu Z, Lin S, Tong Z, et al. Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model. J Ethnopharmacol. 2021;285:114873doi: 10.1016/j.jep.2021.114873.
Xu, Z., Lin, S., Tong, Z., Chen, S., Cao, Y., Li, Q., Jiang, Y., Cai, W., Tong, Y., Zahra, B. S., & Wang, P. (2021). Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model. Journal of ethnopharmacology, 285114873. https://doi.org/10.1016/j.jep.2021.114873
Xu, Zijin, et al. "Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model." Journal of ethnopharmacology vol. 285 (2021): 114873. doi: https://doi.org/10.1016/j.jep.2021.114873
Xu Z, Lin S, Tong Z, Chen S, Cao Y, Li Q, Jiang Y, Cai W, Tong Y, Zahra BS, Wang P. Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model. J Ethnopharmacol. 2021 Nov 27;285:114873. doi: 10.1016/j.jep.2021.114873. Epub 2021 Nov 27. PMID: 34848360.
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Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model.

Journal of ethnopharmacology

Xu Z, Lin S, Tong Z, Chen S, Cao Y, Li Q, Jiang Y, Cai W, Tong Y, Zahra BS, Wang P.
PMID: 34848360
J Ethnopharmacol. 2021 Nov 27;285:114873. doi: 10.1016/j.jep.2021.114873. Epub 2021 Nov 27.

ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine considers that the etiology and pathogenesis of non-alcoholic fatty liver disease (NAFLD) are related to liver depression and qi stagnation. Saffron and its active ingredient, crocetin (CCT), are used for the treatment of metabolic...

Cite
Xu Z, Lin S, Tong Z, et al. Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model. J Ethnopharmacol. 2021;285:114873doi: 10.1016/j.jep.2021.114873.
Xu, Z., Lin, S., Tong, Z., Chen, S., Cao, Y., Li, Q., Jiang, Y., Cai, W., Tong, Y., Zahra, B. S., & Wang, P. (2021). Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model. Journal of ethnopharmacology, 285114873. https://doi.org/10.1016/j.jep.2021.114873
Xu, Zijin, et al. "Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model." Journal of ethnopharmacology vol. 285 (2021): 114873. doi: https://doi.org/10.1016/j.jep.2021.114873
Xu Z, Lin S, Tong Z, Chen S, Cao Y, Li Q, Jiang Y, Cai W, Tong Y, Zahra BS, Wang P. Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model. J Ethnopharmacol. 2021 Nov 27;285:114873. doi: 10.1016/j.jep.2021.114873. Epub 2021 Nov 27. PMID: 34848360.
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Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease.

Hepatitis monthly

El-Shabrawi M, Isa M.
PMID: 22087166
Hepat Mon. 2011 May;11(5):378-9.

No abstract available.

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El-Shabrawi M, Isa M. Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease. Hepat Mon. 2011;11(5):378-9
El-Shabrawi, M., & Isa, M. (2011). Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease. Hepatitis monthly, 11(5), 378-9.
El-Shabrawi, Mortada, and Isa, Mona. "Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease." Hepatitis monthly vol. 11,5 (2011): 378-9.
El-Shabrawi M, Isa M. Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease. Hepat Mon. 2011 May;11(5):378-9. PMID: 22087166; PMCID: PMC3212770.
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Preventive effects of Prangos ferulacea (L.) Lindle on liver damage of diabetic rats induced by alloxan.

Avicenna journal of phytomedicine

Farokhi F, Kaffash Farkhad N, Togmechi A, Soltani Band K.
PMID: 25050232
Avicenna J Phytomed. 2012;2(2):63-71.

OBJECTIVES: Diabetes mellitus is associated with biochemical, physiological and pathological alterations in the liver. The aim of this study was to investigate the effects of hydroalcoholic extract of Prangos ferulacea (L.) Lindle (P.f) on changes in rats´ liver structure...

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Farokhi F, Kaffash Farkhad N, Togmechi A, et al. Preventive effects of Prangos ferulacea (L.) Lindle on liver damage of diabetic rats induced by alloxan. Avicenna J Phytomed. 2012;2(2):63-71
Farokhi, F., Kaffash Farkhad, N., Togmechi, A., & Soltani Band, K. (2012). Preventive effects of Prangos ferulacea (L.) Lindle on liver damage of diabetic rats induced by alloxan. Avicenna journal of phytomedicine, 2(2), 63-71.
Farokhi, Farah, et al. "Preventive effects of Prangos ferulacea (L.) Lindle on liver damage of diabetic rats induced by alloxan." Avicenna journal of phytomedicine vol. 2,2 (2012): 63-71.
Farokhi F, Kaffash Farkhad N, Togmechi A, Soltani Band K. Preventive effects of Prangos ferulacea (L.) Lindle on liver damage of diabetic rats induced by alloxan. Avicenna J Phytomed. 2012;2(2):63-71. PMID: 25050232; PMCID: PMC4075660.
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Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L.

Planta

Holtum JA, Winter K.
PMID: 24271620
Planta. 1982 Jun;155(1):8-16. doi: 10.1007/BF00402925.

The maximum extractable activities of twenty-one photosynthetic and glycolytic enzymes were measured in mature leaves of Mesembryanthemum crystallinum plants, grown under a 12 h light 12 h dark photoperiod, exhibiting photosynthetic characteristics of either a C3 or a Crassulacean...

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Holtum JA, Winter K. Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L. Planta. 1982;155(1):8-16doi: 10.1007/BF00402925.
Holtum, J. A., & Winter, K. (1982). Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L. Planta, 155(1), 8-16. https://doi.org/10.1007/BF00402925
Holtum, J A, and Winter, K. "Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L." Planta vol. 155,1 (1982): 8-16. doi: https://doi.org/10.1007/BF00402925
Holtum JA, Winter K. Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L. Planta. 1982 Jun;155(1):8-16. doi: 10.1007/BF00402925. PMID: 24271620.
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Resveratrol mitigates hepatic injury in rats by regulating oxidative stress, nuclear factor-kappa B, and apoptosis.

Journal of advanced pharmaceutical technology & research

Seif El-Din SH, El-Lakkany NM, Salem MB, Hammam OA, Saleh S, Botros SS.
PMID: 27429929
J Adv Pharm Technol Res. 2016 Jul-Sep;7(3):99-104. doi: 10.4103/2231-4040.184594.

Resveratrol is a naturally occurring polyphenol, possesses several pharmacological activities including anticancer, antioxidant, antidiabetic, antinociceptive, and antiasthmatic activity. Little is known about its hepatoprotective action mechanisms. This study was conceived to explore the possible protective mechanisms of resveratrol compared...

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Seif El-Din SH, El-Lakkany NM, Salem MB, et al. Resveratrol mitigates hepatic injury in rats by regulating oxidative stress, nuclear factor-kappa B, and apoptosis. J Adv Pharm Technol Res. 2016;7(3):99-104doi: 10.4103/2231-4040.184594.
Seif El-Din, S. H., El-Lakkany, N. M., Salem, M. B., Hammam, O. A., Saleh, S., & Botros, S. S. (2016). Resveratrol mitigates hepatic injury in rats by regulating oxidative stress, nuclear factor-kappa B, and apoptosis. Journal of advanced pharmaceutical technology & research, 7(3), 99-104. https://doi.org/10.4103/2231-4040.184594
Seif El-Din, Sayed Hassan, et al. "Resveratrol mitigates hepatic injury in rats by regulating oxidative stress, nuclear factor-kappa B, and apoptosis." Journal of advanced pharmaceutical technology & research vol. 7,3 (2016): 99-104. doi: https://doi.org/10.4103/2231-4040.184594
Seif El-Din SH, El-Lakkany NM, Salem MB, Hammam OA, Saleh S, Botros SS. Resveratrol mitigates hepatic injury in rats by regulating oxidative stress, nuclear factor-kappa B, and apoptosis. J Adv Pharm Technol Res. 2016 Jul-Sep;7(3):99-104. doi: 10.4103/2231-4040.184594. PMID: 27429929; PMCID: PMC4932813.
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Inhibition of C4 photosynthesis by (benzamidooxy)acetic acid.

Photosynthesis research

Nakamoto H, Ku MS, Edwards GE.
PMID: 24458342
Photosynth Res. 1982 Dec;3(4):293-305. doi: 10.1007/BF00034110.

(Benzamidooxy)acetic acid (common name benzadox) which has herbicidal properties was evaluated as a potential inhibitor of photosynthesis in C4 plants. Among enzymes of the C4 pathway, it was a relatively strong inhibitor of alanine aminotransferase in in vitro experiments...

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Nakamoto H, Ku MS, Edwards GE. Inhibition of C4 photosynthesis by (benzamidooxy)acetic acid. Photosynth Res. 1982;3(4):293-305doi: 10.1007/BF00034110.
Nakamoto, H., Ku, M. S., & Edwards, G. E. (1982). Inhibition of C4 photosynthesis by (benzamidooxy)acetic acid. Photosynthesis research, 3(4), 293-305. https://doi.org/10.1007/BF00034110
Nakamoto, H, et al. "Inhibition of C4 photosynthesis by (benzamidooxy)acetic acid." Photosynthesis research vol. 3,4 (1982): 293-305. doi: https://doi.org/10.1007/BF00034110
Nakamoto H, Ku MS, Edwards GE. Inhibition of C4 photosynthesis by (benzamidooxy)acetic acid. Photosynth Res. 1982 Dec;3(4):293-305. doi: 10.1007/BF00034110. PMID: 24458342.
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Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc.

Comparative clinical pathology

Tizhe EV, Ibrahim ND, Fatihu MY, Igbokwe IO, George BD, Ambali SF, Shallangwa JM.
PMID: 25067936
Comp Clin Path. 2014;23:1043-1050. doi: 10.1007/s00580-013-1740-6. Epub 2013 May 03.

A subchronic toxicity study was carried out to assess hepatic and renal functions of rats during oral exposure to glyphosate with zinc for the period of 8 weeks. Forty-eight Wistar rats used for the study were randomized into six...

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Tizhe EV, Ibrahim ND, Fatihu MY, et al. Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc. Comp Clin Path. 2013;23:1043-1050doi: 10.1007/s00580-013-1740-6.
Tizhe, E. V., Ibrahim, N. D., Fatihu, M. Y., Igbokwe, I. O., George, B. D., Ambali, S. F., & Shallangwa, J. M. (2014). Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc. Comparative clinical pathology, 231043-1050. https://doi.org/10.1007/s00580-013-1740-6
Tizhe, Emmanuel Vandi, et al. "Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc." Comparative clinical pathology vol. 23 (2014): 1043-1050. doi: https://doi.org/10.1007/s00580-013-1740-6
Tizhe EV, Ibrahim ND, Fatihu MY, Igbokwe IO, George BD, Ambali SF, Shallangwa JM. Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc. Comp Clin Path. 2014;23:1043-1050. doi: 10.1007/s00580-013-1740-6. Epub 2013 May 03. PMID: 25067936; PMCID: PMC4085474.
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Detection of Renal Insufficiency in a Cohort of Patients With Beta-thalassemia Major Using Cystatin-C.

Journal of pediatric hematology/oncology

Hamdy M, Shaheen I, El-Gammal ZM, Ramadan YM.
PMID: 33843816
J Pediatr Hematol Oncol. 2021 Nov 01;43(8):e1082-e1087. doi: 10.1097/MPH.0000000000002171.

With increased life expectancy among patients with beta-thalassemia major (β-TM) renal insufficiency has been frequently noted because of the persistence of anemia, iron overload and some drug side effects. Serum creatinine becomes elevated in late stage of kidney affection....

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Hamdy M, Shaheen I, El-Gammal ZM, et al. Detection of Renal Insufficiency in a Cohort of Patients With Beta-thalassemia Major Using Cystatin-C. J Pediatr Hematol Oncol. 2021;43(8):e1082-e1087doi: 10.1097/MPH.0000000000002171.
Hamdy, M., Shaheen, I., El-Gammal, Z. M., & Ramadan, Y. M. (2021). Detection of Renal Insufficiency in a Cohort of Patients With Beta-thalassemia Major Using Cystatin-C. Journal of pediatric hematology/oncology, 43(8), e1082-e1087. https://doi.org/10.1097/MPH.0000000000002171
Hamdy, Mona, et al. "Detection of Renal Insufficiency in a Cohort of Patients With Beta-thalassemia Major Using Cystatin-C." Journal of pediatric hematology/oncology vol. 43,8 (2021): e1082-e1087. doi: https://doi.org/10.1097/MPH.0000000000002171
Hamdy M, Shaheen I, El-Gammal ZM, Ramadan YM. Detection of Renal Insufficiency in a Cohort of Patients With Beta-thalassemia Major Using Cystatin-C. J Pediatr Hematol Oncol. 2021 Nov 01;43(8):e1082-e1087. doi: 10.1097/MPH.0000000000002171. PMID: 33843816.
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Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes.

Toxics

Resiere D, Kallel H, Oxybel O, Chabartier C, Florentin J, Brouste Y, Gueye P, Megarbane B, Mehdaoui H.
PMID: 32283693
Toxics. 2020 Apr 09;8(2). doi: 10.3390/toxics8020028.

The epidemiology of severe acute poisonings in the French overseas departments of the Americas remains poorly reported. The main objective of this study was to determine the epidemiology and characteristics of severe acutely poisoned adult patients.METHODS: A retrospective descriptive...

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Resiere D, Kallel H, Oxybel O, et al. Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes. Toxics. 2020;8(2)doi: 10.3390/toxics8020028.
Resiere, D., Kallel, H., Oxybel, O., Chabartier, C., Florentin, J., Brouste, Y., Gueye, P., Megarbane, B., & Mehdaoui, H. (2020). Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes. Toxics, 8(2), . https://doi.org/10.3390/toxics8020028
Resiere, Dabor, et al. "Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes." Toxics vol. 8,2 (2020). doi: https://doi.org/10.3390/toxics8020028
Resiere D, Kallel H, Oxybel O, Chabartier C, Florentin J, Brouste Y, Gueye P, Megarbane B, Mehdaoui H. Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes. Toxics. 2020 Apr 09;8(2). doi: 10.3390/toxics8020028. PMID: 32283693; PMCID: PMC7356022.
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Effects of sodium-glucose co-transporter 2 inhibitors on liver parameters and steatosis: A meta-analysis of randomized clinical trials.

Diabetes/metabolism research and reviews

Coelho FDS, Borges-Canha M, von Hafe M, Neves JS, Vale C, Leite AR, Carvalho D, Leite-Moreira A.
PMID: 33010191
Diabetes Metab Res Rev. 2021 Sep;37(6):e3413. doi: 10.1002/dmrr.3413. Epub 2020 Oct 12.

AIMS: Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in Western countries and a common comorbidity with type 2 diabetes (T2D). It lacks effective pharmacotherapy. We aimed to summarize the evidence on the...

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Coelho FDS, Borges-Canha M, von Hafe M, et al. Effects of sodium-glucose co-transporter 2 inhibitors on liver parameters and steatosis: A meta-analysis of randomized clinical trials. Diabetes Metab Res Rev. 2020;37(6):e3413doi: 10.1002/dmrr.3413.
Coelho, F. D. S., Borges-Canha, M., von Hafe, M., Neves, J. S., Vale, C., Leite, A. R., Carvalho, D., & Leite-Moreira, A. (2021). Effects of sodium-glucose co-transporter 2 inhibitors on liver parameters and steatosis: A meta-analysis of randomized clinical trials. Diabetes/metabolism research and reviews, 37(6), e3413. https://doi.org/10.1002/dmrr.3413
Coelho, Francisca Dos Santos, et al. "Effects of sodium-glucose co-transporter 2 inhibitors on liver parameters and steatosis: A meta-analysis of randomized clinical trials." Diabetes/metabolism research and reviews vol. 37,6 (2021): e3413. doi: https://doi.org/10.1002/dmrr.3413
Coelho FDS, Borges-Canha M, von Hafe M, Neves JS, Vale C, Leite AR, Carvalho D, Leite-Moreira A. Effects of sodium-glucose co-transporter 2 inhibitors on liver parameters and steatosis: A meta-analysis of randomized clinical trials. Diabetes Metab Res Rev. 2021 Sep;37(6):e3413. doi: 10.1002/dmrr.3413. Epub 2020 Oct 12. PMID: 33010191.
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The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis.

Journal of clinical and diagnostic research : JCDR

Cakir OO, Toker A, Ataseven H, Demir A, Polat H.
PMID: 28571184
J Clin Diagn Res. 2017 Apr;11(4):OC17-OC21. doi: 10.7860/JCDR/2017/24958.9621. Epub 2017 Apr 01.

INTRODUCTION: Acute hepatitis is acute inflammation of liver elicited by a large number of causes. It sometimes spontaneously recovers, sometimes may progress to chronic hepatitis. Liver- Fatty Acid Binding Protein (L-FABP) is a small protein that is abundant in...

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Cakir OO, Toker A, Ataseven H, et al. The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis. J Clin Diagn Res. 2017;11(4):OC17-OC21doi: 10.7860/JCDR/2017/24958.9621.
Cakir, O. O., Toker, A., Ataseven, H., Demir, A., & Polat, H. (2017). The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis. Journal of clinical and diagnostic research : JCDR, 11(4), OC17-OC21. https://doi.org/10.7860/JCDR/2017/24958.9621
Cakir, Ozlem Ozer, et al. "The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis." Journal of clinical and diagnostic research : JCDR vol. 11,4 (2017): OC17-OC21. doi: https://doi.org/10.7860/JCDR/2017/24958.9621
Cakir OO, Toker A, Ataseven H, Demir A, Polat H. The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis. J Clin Diagn Res. 2017 Apr;11(4):OC17-OC21. doi: 10.7860/JCDR/2017/24958.9621. Epub 2017 Apr 01. PMID: 28571184; PMCID: PMC5449830.
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