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Showing 85 to 88 of 88 entries
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Lipid profile in acute stroke: A prospective study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Shuaib A, Kalra J, Prasad M, Mantha S, Wallace K.
PMID: 26486709
J Stroke Cerebrovasc Dis. 1992;2(3):125-30. doi: 10.1016/S1052-3057(10)80220-4. Epub 2010 Jun 09.

The dramatic decline in the risk of stroke is most likely secondary to a better control of risk factors, especially hypertension. An increase in low-density lipoprotein (LDL) cholesterol or a decrease in high-density lipoprotein (HDL) cholesterol may be additional...

Targeting the Cholesterol Paradigm in the Risk Reduction for Atherosclerotic Cardiovascular Disease: Does the Mechanism of Action of Pharmacotherapy Matter for Clinical Outcomes?.

Journal of cardiovascular pharmacology and therapeutics

Zhou R, Stouffer GA, Smith SC.
PMID: 34138676
J Cardiovasc Pharmacol Ther. 2021 Nov;26(6):533-549. doi: 10.1177/10742484211023632. Epub 2021 Jun 17.

Hypercholesterolemia is a well-established risk factor for atherosclerotic cardiovascular disease (ASCVD). Low-density lipoprotein cholesterol (LDL-C) has been labeled as "bad" cholesterol and high-density lipoprotein cholesterol (HDL-C) as "good" cholesterol. The prevailing hypothesis is that lowering blood cholesterol levels, especially...

Label-Free Higher Order Structure and Dynamic Investigation Method of Proteins in Solution Using an Enzymatic Reactor Coupled to Electrospray High-Resolution Mass Spectrometry Detection.

Journal of the American Society for Mass Spectrometry

Grifnée E, Kune C, Delvaux C, Quinton L, Far J, Mazzucchelli G, De Pauw E.
PMID: 34969249
J Am Soc Mass Spectrom. 2021 Dec 31; doi: 10.1021/jasms.1c00274. Epub 2021 Dec 31.

For decades, structural analysis of proteins have received considerable attention, from their sequencing to the determination of their 3D structures either in the free state (e.g., no host-guest system, apoproteins) or (non)covalently bound complexes. The elucidation of the 3D...

Reduced Levels of ABCA1 Transporter Are Responsible for the Cholesterol Efflux Impairment in β-Amyloid-Induced Reactive Astrocytes: Potential Rescue from Biomimetic HDLs.

International journal of molecular sciences

Sierri G, Dal Magro R, Vergani B, Leone BE, Formicola B, Taiarol L, Fagioli S, Kravicz M, Tremolizzo L, Calabresi L, Re F.
PMID: 35008528
Int J Mol Sci. 2021 Dec 22;23(1). doi: 10.3390/ijms23010102.

The cerebral synthesis of cholesterol is mainly handled by astrocytes, which are also responsible for apoproteins' synthesis and lipoproteins' assembly required for the cholesterol transport in the brain parenchyma. In Alzheimer disease (AD), these processes are impaired, likely because...

Showing 85 to 88 of 88 entries