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Showing 385 to 396 of 396 entries
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Lipoprotein size is a main determinant for the rate of hydrolysis by exogenous LPL in human plasma.

Journal of lipid research

Kovrov O, Landfors F, Saar-Kovrov V, Näslund U, Olivecrona G.
PMID: 34710432
J Lipid Res. 2021 Oct 26;63(1):100144. doi: 10.1016/j.jlr.2021.100144. Epub 2021 Oct 26.

LPL is a key player in plasma triglyceride metabolism. Consequently, LPL is regulated by several proteins during synthesis, folding, secretion, and transport to its site of action at the luminal side of capillaries, as well as during the catalytic...

Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia.

Annals of general psychiatry

Rao W, Meng X, Li K, Zhang Y, Zhang XY.
PMID: 34930329
Ann Gen Psychiatry. 2021 Dec 20;20(1):56. doi: 10.1186/s12991-021-00376-w.

BACKGROUND: The apolipoprotein E (ApoE) gene polymorphisms are correlated with blood lipid levels and several neuropsychiatric symptoms. Therefore, this study aimed to examine whether the ApoE rs429358 affected the development and clinical symptoms of schizophrenia and to explore the...

Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia.

Annals of general psychiatry

Rao W, Meng X, Li K, Zhang Y, Zhang XY.
PMID: 34930329
Ann Gen Psychiatry. 2021 Dec 20;20(1):56. doi: 10.1186/s12991-021-00376-w.

BACKGROUND: The apolipoprotein E (ApoE) gene polymorphisms are correlated with blood lipid levels and several neuropsychiatric symptoms. Therefore, this study aimed to examine whether the ApoE rs429358 affected the development and clinical symptoms of schizophrenia and to explore the...

Identification of blood-based biomarkers for diagnosis and prognosis of Parkinson's disease: A systematic review of proteomics studies.

Ageing research reviews

Chelliah SS, Bhuvanendran S, Magalingam KB, Kamarudin MNA, Radhakrishnan AK.
PMID: 34798300
Ageing Res Rev. 2021 Nov 16;73:101514. doi: 10.1016/j.arr.2021.101514. Epub 2021 Nov 16.

Parkinson's Disease (PD), a neurodegenerative disorder, is characterised by the loss of motor function and dopamine neurons. Therapeutic avenues remain a challenge due to lack of accuracy in early diagnosis, monitoring of disease progression and limited therapeutic options. Proteomic...

A systematic review and meta-analysis on the impact of oral vitamin E supplementation on apolipoproteins A1 and B100.

Clinical nutrition ESPEN

Hamedi-Kalajahi F, Zarezadeh M, Dehghani A, Musazadeh V, Kolahi A, Shabbidar S, Djafarian K.
PMID: 34857183
Clin Nutr ESPEN. 2021 Dec;46:106-114. doi: 10.1016/j.clnesp.2021.09.013. Epub 2021 Sep 29.

BACKGROUND AND AIM: Cardiovascular diseases (CVDs) are the number one cause of mortality worldwide. Apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), and ApoB/ApoA1 ratio are considered as predictors of CVD alongside with lipid profile. Evidence suggest that nutrients with antioxidant...

Temperature-Responsive Nanoparticles Enable Specific Binding of Apolipoproteins from Human Plasma.

Small (Weinheim an der Bergstrasse, Germany)

Prawatborisut M, Oberländer J, Jiang S, Graf R, Avlasevich Y, Morsbach S, Crespy D, Mailänder V, Landfester K.
PMID: 34761508
Small. 2021 Nov 10;e2103138. doi: 10.1002/smll.202103138. Epub 2021 Nov 10.

Apolipoproteins are an important class of proteins because they provide a so-called stealth effect to nanoparticles. The stealth effect on nanocarriers leads to a reduced unspecific uptake into immune cells and thereby to a prolonged blood circulation time. Herein,...

Sodium salicylate rewires hepatic metabolic pathways in obesity and attenuates IL-1β secretion from adipose tissue: The implications for obesity-impaired reverse cholesterol transport.

Molecular metabolism

Kajani S, Curley S, O'Reilly ME, Yin X, Dillon ET, Guo W, Nilaweera KN, Brennan L, Roche HM, McGillicuddy FC.
PMID: 34954383
Mol Metab. 2021 Dec 24;101425. doi: 10.1016/j.molmet.2021.101425. Epub 2021 Dec 24.

INTRODUCTION: High-fat diet (HFD)-induced obesity impairs clearance of cholesterol through the Reverse Cholesterol Transport (RCT) pathway, with downregulation in hepatic expression of cholesterol and bile acid transporters, namely ABCG5/8 and ABCB11, and reduced high-density lipoprotein (HDL) cholesterol efflux capacity...

Apolipoprotein F concentration, activity, and the properties of LDL controlling ApoF activation in hyperlipidemic plasma.

Journal of lipid research

Morton RE, Mihna D.
PMID: 35016907
J Lipid Res. 2022 Jan 08;100166. doi: 10.1016/j.jlr.2021.100166. Epub 2022 Jan 08.

Apolipoprotein F (ApoF) modulates lipoprotein metabolism by selectively inhibiting cholesteryl ester transfer protein (CETP) activity on LDL. This ApoF activity requires that it is bound to LDL. How hyperlipidemia alters total plasma ApoF and its binding to LDL are...

Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with reduced risk of developing amyotrophic lateral sclerosis.

Journal of neurology, neurosurgery, and psychiatry

Thompson AG, Talbot K, Turner MR.
PMID: 34518331
J Neurol Neurosurg Psychiatry. 2022 Jan;93(1):75-81. doi: 10.1136/jnnp-2021-327133. Epub 2021 Sep 13.

BACKGROUND: Premorbid body mass index, physical activity, diabetes and cardiovascular disease have been associated with an altered risk of developing amyotrophic lateral sclerosis (ALS). There is evidence of shared genetic risk between ALS and lipid metabolism. A very large...

Importance of Apolipoprotein A-I and A-II Composition in HDL and Its Potential for Studying COVID-19 and SARS-CoV-2.

Medicines (Basel, Switzerland)

Cho KH.
PMID: 34357154
Medicines (Basel). 2021 Jul 16;8(7). doi: 10.3390/medicines8070038.

The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19. HDL containing native apoA-I showed potent antiviral activity, while HDL containing glycated...

Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture.

Journal of neuropathology and experimental neurology

Huuska N, Netti E, Tulamo R, Lehti S, Jahromi BR, Kovanen PT, Niemelä M.
PMID: 34534311
J Neuropathol Exp Neurol. 2021 Oct 26;80(10):966-974. doi: 10.1093/jnen/nlab086.

Saccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage. Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative remodeling that precedes its rupture. A better understanding of the pathobiological process is essential for...

The bidirectional link between HDL and COVID-19 infections.

Journal of lipid research

Feingold KR.
PMID: 33741421
J Lipid Res. 2021 Mar 17;62:100067. doi: 10.1016/j.jlr.2021.100067. Epub 2021 Mar 17.

No abstract available.

Showing 385 to 396 of 396 entries