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Showing 56557 to 808 of 808 entries
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Effect of Treatment of Clinical Seizures vs Electrographic Seizures in Full-Term and Near-Term Neonates: A Randomized Clinical Trial.

JAMA network open

Hunt RW, Liley HG, Wagh D, Schembri R, Lee KJ, Shearman AD, Francis-Pester S, deWaal K, Cheong JYL, Olischar M, Badawi N, Wong FY, Osborn DA, Rajadurai VS, Dargaville PA, Headley B, Wright I, Colditz PB.
PMID: 34919132
JAMA Netw Open. 2021 Dec 01;4(12):e2139604. doi: 10.1001/jamanetworkopen.2021.39604.

IMPORTANCE: Seizures in the neonatal period are associated with increased mortality and morbidity. Bedside amplitude-integrated electroencephalography (aEEG) has facilitated the detection of electrographic seizures; however, whether these seizures should be treated remains uncertain.OBJECTIVE: To determine if the active management...

Outpatient Treatment of Chronic Designer Benzodiazepine Use: A Case Report.

Journal of addiction medicine

Hauck TS, Rochon S, Bahra P, Selby P.
PMID: 33900229
J Addict Med. 2021 Apr 26; doi: 10.1097/ADM.0000000000000857. Epub 2021 Apr 26.

BACKGROUND: Novel psychoactive substances, such as designer benzodiazepines unapproved for therapeutic purposes, are an emerging concern worldwide. They have unknown or unpredictable pharmacological properties. Using a case example, we discuss the use of "Xanax bars," which now generally do...

Anticonvulsants and Chromatin-Genes Expression: A Systems Biology Investigation.

Frontiers in neuroscience

Kowalski TW, Gomes JDA, Feira MF, Dupont ÁV, Recamonde-Mendoza M, Vianna FSL.
PMID: 33328862
Front Neurosci. 2020 Nov 25;14:591196. doi: 10.3389/fnins.2020.591196. eCollection 2020.

Embryofetal development is a critical process that needs a strict epigenetic control, however, perturbations in this balance might lead to the occurrence of congenital anomalies. It is known that anticonvulsants potentially affect epigenetics-related genes, however, it is not comprehended...

Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides.

International journal of molecular sciences

Abram M, Jakubiec M, Rapacz A, Mogilski S, Latacz G, Szulczyk B, Szafarz M, Socała K, Nieoczym D, Wyska E, Wlaź P, Kamiński RM, Kamiński K.
PMID: 34884898
Int J Mol Sci. 2021 Dec 03;22(23). doi: 10.3390/ijms222313092.

We report herein a series of water-soluble analogues of previously described anticonvulsants and their detailed in vivo and in vitro characterization. The majority of these compounds demonstrated broad-spectrum anticonvulsant properties in animal seizure models, including the maximal electroshock (MES)...

Showing 56557 to 808 of 808 entries