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Showing 13 to 24 of 4494 entries
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Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target.

Pharmacology research & perspectives

Ankrom W, Wood HB, Xu J, Geissler W, Bateman T, Chatterjee MS, Feng KI, Metzger JM, Strapps WR, Tadin-Strapps M, Seiffert D, Andre P.
PMID: 26977298
Pharmacol Res Perspect. 2016 Jan 15;4(1):e00207. doi: 10.1002/prp2.207. eCollection 2016 Feb.

The benefits of novel oral anticoagulants are hampered by bleeding. Since coagulation factor IX (fIX) lies upstream of fX in the coagulation cascade, and intermediate levels have been associated with reduced incidence of thrombotic events, we evaluated the viability...

Epidemiology, diagnosis, and management of atrial fibrillation in women.

International journal of women's health

Poli D, Antonucci E.
PMID: 26089706
Int J Womens Health. 2015 Jun 11;7:605-14. doi: 10.2147/IJWH.S45925. eCollection 2015.

Atrial fibrillation (AF) is the most common arrhythmia and has become a serious public health problem. Moreover, epidemiological data demonstrate that incidence and prevalence of AF are increasing. Several differences in epidemiological patterns, clinical manifestations, and incidence of stroke...

Antithrombotic Management of Patients with Nonvalvular Atrial Fibrillation and Ischemic Stroke or Transient Ischemic Attack: Executive Summary of the Korean Clinical Practice Guidelines for Stroke.

Journal of stroke

Jung KH, Yu KH, Kim YD, Park JM, Hong KS, Rha JH, Kwon SU, Bae HJ, Heo JH, Lee BC, Yoon BW.
PMID: 26060808
J Stroke. 2015 May;17(2):210-5. doi: 10.5853/jos.2015.17.2.210. Epub 2015 May 29.

Cardioembolic stroke related to nonvalvular atrial fibrillation is associated with a high recurrence rate and high mortality and morbidity. In this population, therefore, optimal anticoagulant therapy is required to prevent the occurrence of second stroke. Oral anticoagulant, warfarin has...

Safety of new oral anticoagulant drugs: a perspective.

Therapeutic advances in drug safety

Vílchez JA, Gallego P, Lip GY.
PMID: 25083259
Ther Adv Drug Saf. 2014 Feb;5(1):8-20. doi: 10.1177/2042098613507945.

The recent development of new oral anticoagulants (NOACs) offers the possibility of efficacy, relative safety and convenience compared with warfarin. This could lead to greater patient compliance, with easier management and improved provision of thromboprophylaxis. Safety whilst using NOACs...

Major themes for 2013 in cardiothoracic and vascular anaesthesia and intensive care.

Heart, lung and vessels

Gutsche JT, Riha H, Patel P, Sahota GS, Valentine E, Ghadimi K, Silvay G, Augoustides JG.
PMID: 25024989
Heart Lung Vessel. 2014;6(2):79-87.

There has been significant progress throughout 2013 in cardiothoracic and vascular anaesthesia and intensive care. There has been a revolution in the medical and interventional management of atrial fibrillation. The medical advances include robust clinical risk scoring systems, novel...

Global assays and the management of oral anticoagulation.

Thrombosis journal

Brinkman HJ.
PMID: 25762867
Thromb J. 2015 Feb 10;13:9. doi: 10.1186/s12959-015-0037-1. eCollection 2015.

Coagulation tests range from global or overall tests to assays specific to individual clotting factors and their inhibitors. Whether a particular test is influenced by an oral anticoagulant depends on the principle of the test and the type of...

Efficacy and safety of the target-specific oral anticoagulants for stroke prevention in atrial fibrillation: the real-life evidence.

Therapeutic advances in drug safety

Russo V, Rago A, Proietti R, Di Meo F, Antonio Papa A, Calabrò P, D'Onofrio A, Nigro G, AlTurki A.
PMID: 28255434
Ther Adv Drug Saf. 2017 Feb;8(2):67-75. doi: 10.1177/2042098616673990. Epub 2016 Oct 24.

The aim of our article is to provide a concise review for clinicians entailing the main studies that evaluated the efficacy and safety of target-specific oral anticoagulants (TSOAs) for thromboembolic stroke prevention in the real-world setting. Atrial fibrillation (AF)...

Beyond warfarin: The advent of new oral anticoagulants.

The Indian journal of radiology & imaging

Laroia ST, Morales S, Laroia AT.
PMID: 26752818
Indian J Radiol Imaging. 2015 Oct-Dec;25(4):375-9. doi: 10.4103/0971-3026.169459.

New oral anticoagulants (NOAC) are the latest addition to anticoagulant armamentarium. Unlike traditional anti-coagulants like warfarin, lab monitoring and management of bleeding complications secondary to these agents is different. As more and more patients are being switched to these...

Heparin induced thrombocytopenia in critically ill: Diagnostic dilemmas and management conundrums.

World journal of critical care medicine

Gupta S, Tiruvoipati R, Green C, Botha J, Tran H.
PMID: 26261772
World J Crit Care Med. 2015 Aug 04;4(3):202-12. doi: 10.5492/wjccm.v4.i3.202. eCollection 2015 Aug 04.

Thrombocytopenia is often noted in critically ill patients. While there are many reasons for thrombocytopenia, the use of heparin and its derivatives is increasingly noted to be associated with thrombocytopenia. Heparin induced thrombocytopenia syndrome (HITS) is a distinct entity...

New oral anticoagulants: their advantages and disadvantages compared with vitamin K antagonists in the prevention and treatment of patients with thromboembolic events.

Therapeutics and clinical risk management

Mekaj YH, Mekaj AY, Duci SB, Miftari EI.
PMID: 26150723
Ther Clin Risk Manag. 2015 Jun 24;11:967-77. doi: 10.2147/TCRM.S84210. eCollection 2015.

Despite the discovery and application of many parenteral (unfractionated and low-molecular-weight heparins) and oral anticoagulant vitamin K antagonist (VKA) drugs, the prevention and treatment of venous and arterial thrombotic phenomena remain major medical challenges. Furthermore, VKAs are the only...

Clinical Course and Results of Surgery for Chronic Subdural Hematomas in Patients on Drugs Affecting Hemostasis.

Journal of Korean Neurosurgical Society

Dziedzic TA, Kunert P, Marchel A.
PMID: 28264245
J Korean Neurosurg Soc. 2017 Mar;60(2):232-238. doi: 10.3340/jkns.2015.1212.005. Epub 2017 Mar 01.

OBJECTIVE: An apparent increase of use of drugs affecting hemostasis in our neurosurgical department since the 1990s has encouraged us to investigate whether these drugs influence the clinical course and results of surgery for chronic subdural hematoma (CSDH).METHODS: This...

Management of Cavoatrial Deep Venous Thrombosis: Incorporating New Strategies.

Seminars in interventional radiology

Zayed MA, De Silva GS, Ramaswamy RS, Sanchez LA.
PMID: 28265127
Semin Intervent Radiol. 2017 Mar;34(1):25-34. doi: 10.1055/s-0036-1597761.

Cavoatrial deep venous thrombosis (DVT) is diagnosed with increasing prevalence. It can be managed medically with anticoagulation or with directed interventions aimed to efficiently reduce the thrombus burden within the target venous segment. The type of management chosen depends...

Showing 13 to 24 of 4494 entries