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Showing 13 to 24 of 87 entries
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Endocrinal and autoimmune linkage: Evidences from a controlled study of subjects with polycystic ovarian syndrome.

Journal of human reproductive sciences

Arora S, Sinha K, Kolte S, Mandal A.
PMID: 27110073
J Hum Reprod Sci. 2016 Jan-Mar;9(1):18-22. doi: 10.4103/0974-1208.178636.

BACKGROUND: Polycystic ovary syndrome (PCOS) is a metabolic syndrome, characterized by anovulation, hyperandrogenism, and polycystic ovary. With serological markers of autoimmunity found elevated in PCOS, there is a possible link between autoimmunity and PCOS.AIM: The study aimed to investigate...

Experimental and Theoretical Investigation of Sodiated Multimers of Steroid Epimers with Ion Mobility-Mass Spectrometry.

Journal of the American Society for Mass Spectrometry

Chouinard CD, Cruzeiro VWD, Roitberg AE, Yost RA.
PMID: 27914014
J Am Soc Mass Spectrom. 2017 Feb;28(2):323-331. doi: 10.1007/s13361-016-1525-7. Epub 2016 Dec 02.

Ion mobility-mass spectrometry (IM-MS) has recently seen increased use in the analysis of small molecules, especially in the field of metabolomics, for increased breadth of information and improved separation of isomers. In this study, steroid epimers androsterone and trans-androsterone...

Urinary Steroid Profile in Elite Female Athletes in Relation to Serum Androgens and in Comparison With Untrained Controls.

Frontiers in physiology

Eklund E, Andersson A, Ekström L, Hirschberg AL.
PMID: 34526910
Front Physiol. 2021 Aug 30;12:702305. doi: 10.3389/fphys.2021.702305. eCollection 2021.

INTRODUCTION: In female athletes, the interpretation of doping tests is complex due to hormonal variations during the menstrual cycle and hormonal contraceptive use, both influencing the urinary steroid profile. Exercise is suggested to affect circulating steroid hormone levels, and...

Liquid chromatography-mass spectrometry behavior of Girard's reagent T derivatives of oxosteroid intact phase II metabolites for doping control purposes.

Drug testing and analysis

Kiousi P, Fragkaki AG, Kioukia-Fougia N, Angelis YS.
PMID: 33942526
Drug Test Anal. 2021 May 03; doi: 10.1002/dta.3056. Epub 2021 May 03.

Intact phase II steroid metabolites have poor product ion mass spectra under collision-induced dissociation (CID) conditions. Therefore, we present herein the liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/(MS)) behavior of intact phase II metabolites of oxosteroids after derivatization. Based on...

Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis.

Heliyon

Engeli RT, Fürstenberger C, Kratschmar DV, Odermatt A.
PMID: 29560447
Heliyon. 2018 Feb 01;4(2):e00527. doi: 10.1016/j.heliyon.2018.e00527. eCollection 2018 Feb.

Androgen biosynthesis in males occurs to a large extent in testicular Leydig cells. This study focused on the evaluation of three murine Leydig cell lines as potential screening tool to test xenobiotics interfering with gonadal androgen synthesis. The final...

Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells.

Frontiers in physiology

Ye L, Li X, Li L, Chen H, Ge RS.
PMID: 28701961
Front Physiol. 2017 Jun 28;8:430. doi: 10.3389/fphys.2017.00430. eCollection 2017.

Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs). SLCs are spindle-shaped cells that lack steroidogenic cell markers,...

Relativein vitro effectiveness of estradiol-17β, androgens, corticosteroids, progesterone and other pregnene derivatives on germinal vesicle breakdown in oocytes of Indian major carps,Labeo rohita, Cirrhinus mrigala andCatla catla.

Fish physiology and biochemistry

Haider S, Inbaraj RM.
PMID: 24221598
Fish Physiol Biochem. 1989 Sep;6(5):289-95. doi: 10.1007/BF01881683.

The relative effectiveness of estradiol-17β, androgens, corticosteroids, progesterone and other pregnene derivatives on germinal vesicle breakdown (GVBD) was investigatedin vitro using folliculated oocytes of three carps,Labeo rohita, Cirrhinus mrigala, andCatla catla. In all three species progesterone and 17α-hydroxyprogesterone could...

Reprint of "In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3".

The Journal of steroid biochemistry and molecular biology

Roy J, Fournier MA, Maltais R, Kenmogne LC, Poirier D.
PMID: 26291835
J Steroid Biochem Mol Biol. 2015 Sep;153:170-8. doi: 10.1016/j.jsbmb.2015.08.014. Epub 2015 Aug 19.

17β-Hydroxysteroid dehydrogenase type 3 (17β-HSD3 or HSD17B3) catalyzes the last step in the biosynthesis of the potent androgen testosterone (T), by stereoselectively reducing the C17 ketone of 4-androstene-3,17-dione (4-dione), with NADPH as cofactor. Since T plays an important role...

Monofluoroalkenylation of Dimethylamino Compounds through Radical-Radical Cross-Coupling.

Angewandte Chemie (International ed. in English)

Xie J, Yu J, Rudolph M, Rominger F, Hashmi AS.
PMID: 27351709
Angew Chem Int Ed Engl. 2016 Aug 01;55(32):9416-21. doi: 10.1002/anie.201602347. Epub 2016 Jun 28.

An unprecedented and challenging radical-radical cross-coupling of α-aminoalkyl radicals with monofluoroalkenyl radicals derived from gem-difluoroalkenes was achieved. This first example of tandem C(sp(3) )-H and C(sp(2) )-F bond functionalization through visible-light photoredox catalysis offers a facile and flexible access...

Oestrogenic Action of Compounds of the Androsterone-Testosterone Series.

British medical journal

Deanesly R, Parkes AS.
PMID: 20779715
Br Med J. 1936 Feb 08;1(3918):257-8. doi: 10.1136/bmj.1.3918.257.

No abstract available.

Studies on steroid fever: I. Production of leukocyte pyrogen in vitro by etiocholanolone.

The Journal of clinical investigation

Bodel P, Dillard M.
PMID: 16695933
J Clin Invest. 1968 Jan;47(1):107-17. doi: 10.1172/JCI105701.

When a serum-buffer solution of etiocholanolone is incubated with human blood leukocytes in vitro, a pyrogen is released. Like endogenous pyrogen of leukocyte origin, this pyrogen produces prompt monophasic fevers in rabbits, does not induce fever tolerance when given...

The effects of water-soluble preparations of androsterone and androsterone-diol on castrated rats.

The Biochemical journal

Korenchevsky V, Dennison M, Simpson SL.
PMID: 16745889
Biochem J. 1935 Sep;29(9):2131-42. doi: 10.1042/bj0292131.

No abstract available.

Showing 13 to 24 of 87 entries