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Showing 13 to 24 of 1627 entries
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Acute cocaine exposure elicits rises in calcium in arousal-related laterodorsal tegmental neurons.

Pharmacology research & perspectives

Lambert MØ, Ipsen TH, Kohlmeier KA.
PMID: 28596834
Pharmacol Res Perspect. 2016 Dec 23;5(1):e00282. doi: 10.1002/prp2.282. eCollection 2017 Feb.

Cocaine has strong reinforcing properties, which underlie its high addiction potential. Reinforcement of use of addictive drugs is associated with rises in dopamine (DA) in mesoaccumbal circuitry. Excitatory afferent input to mesoaccumbal circuitry sources from the laterodorsal tegmental nucleus...

Perinatal 6-Hydroxydopamine Modeling of ADHD.

Current topics in behavioral neurosciences

Kostrzewa JP, Kostrzewa RA, Kostrzewa RM, Brus R, Nowak P.
PMID: 26475157
Curr Top Behav Neurosci. 2016;29:279-293. doi: 10.1007/7854_2015_397.

The neonatally 6-hydroxydopamine (n6-OHDA)-lesioned rat has been the standard for 40 years, as an animal model of attention-deficit hyperactivity disorder (ADHD). Rats so lesioned during postnatal ontogeny are characterized by ~99 % destruction of dopaminergic nerves in pars compacta...

Electrochemical impedance spectroscopic sensing of methamphetamine by a specific aptamer.

BioImpacts : BI

Ebrahimi M, Johari-Ahar M, Hamzeiy H, Barar J, Mashinchian O, Omidi Y.
PMID: 23678446
Bioimpacts. 2012;2(2):91-5. doi: 10.5681/bi.2012.013. Epub 2012 May 20.

INTRODUCTION: Electrochemical impedance spectroscopy (EIS) is a simple and highly sensitive technique that can be used for evaluation of the aptamer-target interaction even in a label-free approach.METHODS: To pursue the effectiveness of EIS, in the current study, the folding...

Memory impairment induced by amphetamine derivatives in laboratory animals and in humans: a review.

Biomolecular concepts

Camarasa J, Rodrigo T, Pubill D, Escubedo E.
PMID: 25436520
Biomol Concepts. 2012 Feb;3(1):1-12. doi: 10.1515/bmc.2011.048.

Abstract The 20th century brought with it the so-called club drugs (the most notorious being amphetamine derivatives), which are used by young adults at all-night dance parties. Methamphet-amine and 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) are synthetic drugs with stimulant and...

Agonist signalling properties of radiotracers used for imaging of dopamine D2/3 receptors.

EJNMMI research

van Wieringen JP, Michel MC, Janssen HM, Janssen AG, Elsinga PH, Booij J.
PMID: 25977878
EJNMMI Res. 2014 Oct 07;4:53. doi: 10.1186/s13550-014-0053-3. eCollection 2014.

BACKGROUND: Dopamine D2/3 receptor (D2/3R) agonist radiopharmaceuticals are considered superior to antagonists to detect dopamine release, e.g. induced by amphetamines. Agonists bind preferentially to the high-affinity state of the dopamine D2R, which has been proposed as the reason why...

Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine Binding.

Frontiers in neurology

Cheng MH, Block E, Hu F, Cobanoglu MC, Sorkin A, Bahar I.
PMID: 26106364
Front Neurol. 2015 Jun 09;6:134. doi: 10.3389/fneur.2015.00134. eCollection 2015.

Human dopamine (DA) transporter (hDAT) regulates dopaminergic signaling in the central nervous system by maintaining the synaptic concentration of DA at physiological levels, upon reuptake of DA into presynaptic terminals. DA translocation involves the co-transport of two sodium ions...

Dopamine Transporter Activity Is Modulated by α-synuclein.

The Journal of biological chemistry

Butler B, Goodwin S, Saha K, Becker J, Sambo D, Davari P, Khoshbouei H.
PMID: 26048988
J Biol Chem. 2015 Jun 05; doi: 10.1074/jbc.M115.639880. Epub 2015 Jun 05.

The duration and strength of the dopaminergic signal is regulated by the dopamine transporter (DAT). Drug addiction, neurodegenerative and neuropsychiatric diseases have all been associated with altered DAT activity. The membrane localization and the activity of DAT are regulated...

Substance misuse in Aboriginal Australians.

Addiction biology

Gracey M.
PMID: 26736078
Addict Biol. 1998 Jan;3(1):29-46. doi: 10.1080/13556219872326.

Australia's Aborigines lived in isolation from the rest of humanity as successful hunter-gatherers for tens of thousands of years. That isolation ended abruptly with British colonization in the late 18th century and was followed by a traumatic 200 years...

Central 5-HT2 antagonists: A preclinical evaluation of a therapeutic potential.

Acta neuropsychiatrica

Meert TF, Awouters F.
PMID: 26952556
Acta Neuropsychiatr. 1990 Dec;2(4):101-9. doi: 10.1017/S0924270800034517.

A preclinical evaluation is presented of the serotonin 5-HT2 antagonists ritanserin and risperidone. Whereas ritanserin is a relative selective 5-HT2 antagonist, risperidone is a potent 5-HT2 and catecholamine antagonist. The pharmacological differences between both drugs are also observed in...

A Novel PKC Inhibitor Shows Promise for Amphetamine Use Disorders.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Newman AH.
PMID: 28593999
Neuropsychopharmacology. 2017 Sep;42(10):1929-1930. doi: 10.1038/npp.2017.116. Epub 2017 Jun 08.

No abstract available.

Acceleration of cardiovascular-biological age by amphetamine exposure is a power function of chronological age.

Heart Asia

Reece AS, Norman A, Hulse GK.
PMID: 28243315
Heart Asia. 2017 Jan 10;9(1):30-38. doi: 10.1136/heartasia-2016-010832. eCollection 2017.

BACKGROUND: Amphetamine abuse is becoming more widespread internationally. The possibility that its many cardiovascular complications are associated with a prematurely aged cardiovascular system, and indeed biological organism systemically, has not been addressed.METHODS: Radial arterial pulse tonometry was performed using...

Differentiation of ring-substituted bromoamphetamine analogs by gas chromatography-tandem mass spectrometry.

Forensic toxicology

Inoue H, Negishi S, Nakazono Y, Iwata YT, Tsujikawa K, Ohtsuru O, Miyamoto K, Yamashita T, Kasuya F.
PMID: 26793279
Forensic Toxicol. 2016;34:125-132. doi: 10.1007/s11419-015-0296-3. Epub 2015 Nov 14.

There has been a rapid increase over the last decade in the appearance of new non-controlled psychoactive substances. Minor changes in the chemical structures of these compounds, such as the extension of an alkyl residue or replacement of a...

Showing 13 to 24 of 1627 entries