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A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis.

Journal of chromatography. A

Chu C, Zang Y, Yang F, Zou Y, Li J, Liu EH, Yi T, Yan J, Tong S.
PMID: 34998026
J Chromatogr A. 2021 Dec 30;1664:462794. doi: 10.1016/j.chroma.2021.462794. Epub 2021 Dec 30.

A sensitive capillary electrophoresis strategy was developed by combining salting-out assisted liquid-liquid extraction and online three-step stacking to detect trace quantities of antitumour indole alkaloids in complex biological samples. The proposed strategy fully exploits these two technologies such that...

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Chu C, Zang Y, Yang F, et al. A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis. J Chromatogr A. 2021;1664:462794doi: 10.1016/j.chroma.2021.462794.
Chu, C., Zang, Y., Yang, F., Zou, Y., Li, J., Liu, E. H., Yi, T., Yan, J., & Tong, S. (2021). A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis. Journal of chromatography. A, 1664462794. https://doi.org/10.1016/j.chroma.2021.462794
Chu, Chu, et al. "A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis." Journal of chromatography. A vol. 1664 (2021): 462794. doi: https://doi.org/10.1016/j.chroma.2021.462794
Chu C, Zang Y, Yang F, Zou Y, Li J, Liu EH, Yi T, Yan J, Tong S. A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis. J Chromatogr A. 2021 Dec 30;1664:462794. doi: 10.1016/j.chroma.2021.462794. Epub 2021 Dec 30. PMID: 34998026.
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LC-ESI-MS/MS Simultaneous Analysis Method Coupled with Cation-Exchange Solid-Phase Extraction for Determination of Pyrrolizidine Alkaloids on Five Kinds of Herbal Medicines.

Journal of AOAC International

Jeong SH, Choi EY, Kim J, Lee C, Kang J, Cho S, Ko KY.
PMID: 34297098
J AOAC Int. 2021 Dec 11;104(6):1514-1525. doi: 10.1093/jaoacint/qsab098.

BACKGROUND: Pyrrolizidine alkaloids (PAs) are naturally occurring plant toxins associated with potential hepatic and carcinogenic diseases in humans and animals. The concern over PAs has increased as the consumption of herbal medicines has increased.OBJECTIVE: This study aimed to develop...

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Jeong SH, Choi EY, Kim J, et al. LC-ESI-MS/MS Simultaneous Analysis Method Coupled with Cation-Exchange Solid-Phase Extraction for Determination of Pyrrolizidine Alkaloids on Five Kinds of Herbal Medicines. J AOAC Int. 2021;104(6):1514-1525doi: 10.1093/jaoacint/qsab098.
Jeong, S. H., Choi, E. Y., Kim, J., Lee, C., Kang, J., Cho, S., & Ko, K. Y. (2021). LC-ESI-MS/MS Simultaneous Analysis Method Coupled with Cation-Exchange Solid-Phase Extraction for Determination of Pyrrolizidine Alkaloids on Five Kinds of Herbal Medicines. Journal of AOAC International, 104(6), 1514-1525. https://doi.org/10.1093/jaoacint/qsab098
Jeong, Se Hee, et al. "LC-ESI-MS/MS Simultaneous Analysis Method Coupled with Cation-Exchange Solid-Phase Extraction for Determination of Pyrrolizidine Alkaloids on Five Kinds of Herbal Medicines." Journal of AOAC International vol. 104,6 (2021): 1514-1525. doi: https://doi.org/10.1093/jaoacint/qsab098
Jeong SH, Choi EY, Kim J, Lee C, Kang J, Cho S, Ko KY. LC-ESI-MS/MS Simultaneous Analysis Method Coupled with Cation-Exchange Solid-Phase Extraction for Determination of Pyrrolizidine Alkaloids on Five Kinds of Herbal Medicines. J AOAC Int. 2021 Dec 11;104(6):1514-1525. doi: 10.1093/jaoacint/qsab098. PMID: 34297098.
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A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis.

Journal of chromatography. A

Chu C, Zang Y, Yang F, Zou Y, Li J, Liu EH, Yi T, Yan J, Tong S.
PMID: 34998026
J Chromatogr A. 2021 Dec 30;1664:462794. doi: 10.1016/j.chroma.2021.462794. Epub 2021 Dec 30.

A sensitive capillary electrophoresis strategy was developed by combining salting-out assisted liquid-liquid extraction and online three-step stacking to detect trace quantities of antitumour indole alkaloids in complex biological samples. The proposed strategy fully exploits these two technologies such that...

Cite
Chu C, Zang Y, Yang F, et al. A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis. J Chromatogr A. 2021;1664:462794doi: 10.1016/j.chroma.2021.462794.
Chu, C., Zang, Y., Yang, F., Zou, Y., Li, J., Liu, E. H., Yi, T., Yan, J., & Tong, S. (2021). A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis. Journal of chromatography. A, 1664462794. https://doi.org/10.1016/j.chroma.2021.462794
Chu, Chu, et al. "A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis." Journal of chromatography. A vol. 1664 (2021): 462794. doi: https://doi.org/10.1016/j.chroma.2021.462794
Chu C, Zang Y, Yang F, Zou Y, Li J, Liu EH, Yi T, Yan J, Tong S. A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis. J Chromatogr A. 2021 Dec 30;1664:462794. doi: 10.1016/j.chroma.2021.462794. Epub 2021 Dec 30. PMID: 34998026.
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Overproduction of medicinal ergot alkaloids based on a fungal platform.

Metabolic engineering

Yao Y, Wang W, Shi W, Yan R, Zhang J, Wei G, Liu L, Che Y, An C, Gao SS.
PMID: 34902590
Metab Eng. 2021 Dec 10; doi: 10.1016/j.ymben.2021.12.002. Epub 2021 Dec 10.

Privileged ergot alkaloids (EAs) produced by the fungal genus Claviceps are used to treat a wide range of diseases. However, their use and research have been hampered by the challenging genetic engineering of Claviceps. Here we systematically refactored and...

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Yao Y, Wang W, Shi W, et al. Overproduction of medicinal ergot alkaloids based on a fungal platform. Metab Eng. 2021;doi: 10.1016/j.ymben.2021.12.002.
Yao, Y., Wang, W., Shi, W., Yan, R., Zhang, J., Wei, G., Liu, L., Che, Y., An, C., & Gao, S. S. (2021). Overproduction of medicinal ergot alkaloids based on a fungal platform. Metabolic engineering, . https://doi.org/10.1016/j.ymben.2021.12.002
Yao, Yongpeng, et al. "Overproduction of medicinal ergot alkaloids based on a fungal platform." Metabolic engineering vol. (2021). doi: https://doi.org/10.1016/j.ymben.2021.12.002
Yao Y, Wang W, Shi W, Yan R, Zhang J, Wei G, Liu L, Che Y, An C, Gao SS. Overproduction of medicinal ergot alkaloids based on a fungal platform. Metab Eng. 2021 Dec 10; doi: 10.1016/j.ymben.2021.12.002. Epub 2021 Dec 10. PMID: 34902590.
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Complete biosynthesis of the bisbenzylisoquinoline alkaloids guattegaumerine and berbamunine in yeast.

Proceedings of the National Academy of Sciences of the United States of America

Payne JT, Valentic TR, Smolke CD.
PMID: 34903659
Proc Natl Acad Sci U S A. 2021 Dec 21;118(51). doi: 10.1073/pnas.2112520118.

Benzylisoquinoline alkaloids (BIAs) are a diverse class of medicinal plant natural products. Nearly 500 dimeric bisbenzylisoquinoline alkaloids (bisBIAs), produced by the coupling of two BIA monomers, have been characterized and display a range of pharmacological properties, including anti-inflammatory, antitumor,...

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Payne JT, Valentic TR, Smolke CD. Complete biosynthesis of the bisbenzylisoquinoline alkaloids guattegaumerine and berbamunine in yeast. Proc Natl Acad Sci U S A. 2021;118(51)doi: 10.1073/pnas.2112520118.
Payne, J. T., Valentic, T. R., & Smolke, C. D. (2021). Complete biosynthesis of the bisbenzylisoquinoline alkaloids guattegaumerine and berbamunine in yeast. Proceedings of the National Academy of Sciences of the United States of America, 118(51), . https://doi.org/10.1073/pnas.2112520118
Payne, James T, et al. "Complete biosynthesis of the bisbenzylisoquinoline alkaloids guattegaumerine and berbamunine in yeast." Proceedings of the National Academy of Sciences of the United States of America vol. 118,51 (2021). doi: https://doi.org/10.1073/pnas.2112520118
Payne JT, Valentic TR, Smolke CD. Complete biosynthesis of the bisbenzylisoquinoline alkaloids guattegaumerine and berbamunine in yeast. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51). doi: 10.1073/pnas.2112520118. PMID: 34903659.
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Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches.

mBio

Chen B, Sun Y, Li S, Yin Y, Wang C.
PMID: 34903054
mBio. 2021 Dec 14;e0327921. doi: 10.1128/mbio.03279-21. Epub 2021 Dec 14.

Diverse 2-pyridone alkaloids have been identified with an array of biological and pharmaceutical activities, including the development of drugs. However, the biosynthetic regulation and chemical ecology of 2-pyridones remain largely elusive. Here, we report the inductive activation of the...

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Chen B, Sun Y, Li S, et al. Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches. mBio. 2021;e0327921doi: 10.1128/mbio.03279-21.
Chen, B., Sun, Y., Li, S., Yin, Y., & Wang, C. (2021). Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches. mBio, e0327921. https://doi.org/10.1128/mbio.03279-21
Chen, Bo, et al. "Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches." mBio vol. (2021): e0327921. doi: https://doi.org/10.1128/mbio.03279-21
Chen B, Sun Y, Li S, Yin Y, Wang C. Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches. mBio. 2021 Dec 14;e0327921. doi: 10.1128/mbio.03279-21. Epub 2021 Dec 14. PMID: 34903054.
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Isolation, Structural Characterization and Antidiabetic Activity of New Diketopiperazine Alkaloids from Mangrove Endophytic Fungus .

Marine drugs

Ye G, Huang C, Li J, Chen T, Tang J, Liu W, Long Y.
PMID: 34356827
Mar Drugs. 2021 Jul 20;19(7). doi: 10.3390/md19070402.

Six new DIKETOPIPERAZINE alkaloids aspergiamides A-F (

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Ye G, Huang C, Li J, et al. Isolation, Structural Characterization and Antidiabetic Activity of New Diketopiperazine Alkaloids from Mangrove Endophytic Fungus . Mar Drugs. 2021;19(7)doi: 10.3390/md19070402.
Ye, G., Huang, C., Li, J., Chen, T., Tang, J., Liu, W., & Long, Y. (2021). Isolation, Structural Characterization and Antidiabetic Activity of New Diketopiperazine Alkaloids from Mangrove Endophytic Fungus . Marine drugs, 19(7), . https://doi.org/10.3390/md19070402
Ye, Geting, et al. "Isolation, Structural Characterization and Antidiabetic Activity of New Diketopiperazine Alkaloids from Mangrove Endophytic Fungus ." Marine drugs vol. 19,7 (2021). doi: https://doi.org/10.3390/md19070402
Ye G, Huang C, Li J, Chen T, Tang J, Liu W, Long Y. Isolation, Structural Characterization and Antidiabetic Activity of New Diketopiperazine Alkaloids from Mangrove Endophytic Fungus . Mar Drugs. 2021 Jul 20;19(7). doi: 10.3390/md19070402. PMID: 34356827; PMCID: PMC8304462.
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Berberine as a Potential Anticancer Agent: A Comprehensive Review.

Molecules (Basel, Switzerland)

Rauf A, Abu-Izneid T, Khalil AA, Imran M, Shah ZA, Emran TB, Mitra S, Khan Z, Alhumaydhi FA, Aljohani ASM, Khan I, Rahman MM, Jeandet P, Gondal TA.
PMID: 34885950
Molecules. 2021 Dec 04;26(23). doi: 10.3390/molecules26237368.

Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial amount of research has been conducted to date to establish the anticancer potential of BBR. The present review consolidates salient information concerning the promising anticancer activity of...

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Rauf A, Abu-Izneid T, Khalil AA, et al. Berberine as a Potential Anticancer Agent: A Comprehensive Review. Molecules. 2021;26(23)doi: 10.3390/molecules26237368.
Rauf, A., Abu-Izneid, T., Khalil, A. A., Imran, M., Shah, Z. A., Emran, T. B., Mitra, S., Khan, Z., Alhumaydhi, F. A., Aljohani, A. S. M., Khan, I., Rahman, M. M., Jeandet, P., & Gondal, T. A. (2021). Berberine as a Potential Anticancer Agent: A Comprehensive Review. Molecules (Basel, Switzerland), 26(23), . https://doi.org/10.3390/molecules26237368
Rauf, Abdur, et al. "Berberine as a Potential Anticancer Agent: A Comprehensive Review." Molecules (Basel, Switzerland) vol. 26,23 (2021). doi: https://doi.org/10.3390/molecules26237368
Rauf A, Abu-Izneid T, Khalil AA, Imran M, Shah ZA, Emran TB, Mitra S, Khan Z, Alhumaydhi FA, Aljohani ASM, Khan I, Rahman MM, Jeandet P, Gondal TA. Berberine as a Potential Anticancer Agent: A Comprehensive Review. Molecules. 2021 Dec 04;26(23). doi: 10.3390/molecules26237368. PMID: 34885950; PMCID: PMC8658774.
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Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer.

Pharmacological research

Chen MH, Gu YY, Zhang AL, Sze DM, Mo SL, May BH.
PMID: 34298110
Pharmacol Res. 2021 Sep;171:105778. doi: 10.1016/j.phrs.2021.105778. Epub 2021 Jul 20.

The plant Sophora flavescens Ait. has been used in the clinical management of colorectal cancer (CRC). Its constituent compounds, notably the alkaloids matrine, oxymatrine, and sophoridine, have received considerable research attention in experimental models of CRC in vivo and...

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Chen MH, Gu YY, Zhang AL, et al. Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer. Pharmacol Res. 2021;171:105778doi: 10.1016/j.phrs.2021.105778.
Chen, M. H., Gu, Y. Y., Zhang, A. L., Sze, D. M., Mo, S. L., & May, B. H. (2021). Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer. Pharmacological research, 171105778. https://doi.org/10.1016/j.phrs.2021.105778
Chen, Meng-Hua, et al. "Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer." Pharmacological research vol. 171 (2021): 105778. doi: https://doi.org/10.1016/j.phrs.2021.105778
Chen MH, Gu YY, Zhang AL, Sze DM, Mo SL, May BH. Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer. Pharmacol Res. 2021 Sep;171:105778. doi: 10.1016/j.phrs.2021.105778. Epub 2021 Jul 20. PMID: 34298110.
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Synthesis and Applications of Carbohydrate-Based Organocatalysts.

Molecules (Basel, Switzerland)

Wojaczyńska E, Steppeler F, Iwan D, Scherrmann MC, Marra A.
PMID: 34885873
Molecules. 2021 Nov 30;26(23). doi: 10.3390/molecules26237291.

Organocatalysis is a very useful tool for the asymmetric synthesis of biologically or pharmacologically active compounds because it avoids the use of noxious metals, which are difficult to eliminate from the target products. Moreover, in many cases, the organocatalysed...

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Wojaczyńska E, Steppeler F, Iwan D, et al. Synthesis and Applications of Carbohydrate-Based Organocatalysts. Molecules. 2021;26(23)doi: 10.3390/molecules26237291.
Wojaczyńska, E., Steppeler, F., Iwan, D., Scherrmann, M. C., & Marra, A. (2021). Synthesis and Applications of Carbohydrate-Based Organocatalysts. Molecules (Basel, Switzerland), 26(23), . https://doi.org/10.3390/molecules26237291
Wojaczyńska, Elżbieta, et al. "Synthesis and Applications of Carbohydrate-Based Organocatalysts." Molecules (Basel, Switzerland) vol. 26,23 (2021). doi: https://doi.org/10.3390/molecules26237291
Wojaczyńska E, Steppeler F, Iwan D, Scherrmann MC, Marra A. Synthesis and Applications of Carbohydrate-Based Organocatalysts. Molecules. 2021 Nov 30;26(23). doi: 10.3390/molecules26237291. PMID: 34885873; PMCID: PMC8659088.
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Pharmacokinetic and excretion study of eight active constituents in rat by LC-MS/MS after oral administration of the Toddalia asiatica extract.

Analytical biochemistry

Qiu J, Zhu M, Wang Y, Chen B, Bai R, Chen F, Li Y, Zhou Y, Zhang L.
PMID: 34637784
Anal Biochem. 2021 Oct 09;114407. doi: 10.1016/j.ab.2021.114407. Epub 2021 Oct 09.

Toddalia asiatica L., a significant medicinal plant in the family Rutaceae, has been applied to treat rheumatoid diseases for decades. Its pharmacological activities are mainly attributed to the existence of generous coumarins and alkaloids; however, the pharmacokinetics of Toddalia...

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Qiu J, Zhu M, Wang Y, et al. Pharmacokinetic and excretion study of eight active constituents in rat by LC-MS/MS after oral administration of the Toddalia asiatica extract. Anal Biochem. 2021;114407doi: 10.1016/j.ab.2021.114407.
Qiu, J., Zhu, M., Wang, Y., Chen, B., Bai, R., Chen, F., Li, Y., Zhou, Y., & Zhang, L. (2021). Pharmacokinetic and excretion study of eight active constituents in rat by LC-MS/MS after oral administration of the Toddalia asiatica extract. Analytical biochemistry, 114407. https://doi.org/10.1016/j.ab.2021.114407
Qiu, Jingwen, et al. "Pharmacokinetic and excretion study of eight active constituents in rat by LC-MS/MS after oral administration of the Toddalia asiatica extract." Analytical biochemistry vol. (2021): 114407. doi: https://doi.org/10.1016/j.ab.2021.114407
Qiu J, Zhu M, Wang Y, Chen B, Bai R, Chen F, Li Y, Zhou Y, Zhang L. Pharmacokinetic and excretion study of eight active constituents in rat by LC-MS/MS after oral administration of the Toddalia asiatica extract. Anal Biochem. 2021 Oct 09;114407. doi: 10.1016/j.ab.2021.114407. Epub 2021 Oct 09. PMID: 34637784.
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Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis .

Journal of advanced research

Zhang Q, Liu J, Duan H, Li R, Peng W, Wu C.
PMID: 35024180
J Adv Res. 2021 Jul 06;34:43-63. doi: 10.1016/j.jare.2021.06.023. eCollection 2021 Dec.

INTRODUCTION: Recently, Nrf2/HO-1 has received extensive attention as the main regulatory pathway of intracellular defense against oxidative stress and is considered an ideal target for alleviating endothelial cell (EC) injury.OBJECTIVES: This paper aimed to summarized the natural monomers/extracts that...

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Zhang Q, Liu J, Duan H, et al. Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis . J Adv Res. 2021;34:43-63doi: 10.1016/j.jare.2021.06.023.
Zhang, Q., Liu, J., Duan, H., Li, R., Peng, W., & Wu, C. (2021). Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis . Journal of advanced research, 3443-63. https://doi.org/10.1016/j.jare.2021.06.023
Zhang, Qing, et al. "Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis ." Journal of advanced research vol. 34 (2021): 43-63. doi: https://doi.org/10.1016/j.jare.2021.06.023
Zhang Q, Liu J, Duan H, Li R, Peng W, Wu C. Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis . J Adv Res. 2021 Jul 06;34:43-63. doi: 10.1016/j.jare.2021.06.023. eCollection 2021 Dec. PMID: 35024180; PMCID: PMC8655139.
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Showing 4309 to 4320 of 4320 entries