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Showing 5905 to 5916 of 5931 entries
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Electrochemical detection of alkaline phosphatase activity via atom transfer radical polymerization.

Bioelectrochemistry (Amsterdam, Netherlands)

Li X, Lu J, Li Z, Yang H, Li W, Liu Y, Miao M.
PMID: 34808503
Bioelectrochemistry. 2021 Nov 16;144:107998. doi: 10.1016/j.bioelechem.2021.107998. Epub 2021 Nov 16.

Alkaline phosphatase (ALP) activity is a diagnostic indicator for a variety of clinical diseases. In this study, an electrochemical method for detecting ALP activity through activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) was developed. Specifically,...

Differential gene expression analysis for osteosarcoma lung metastases.

Cancer biomarkers : section A of Disease markers

Liu F, Pang X, Yu Z, Wang K.
PMID: 34511489
Cancer Biomark. 2021 Sep 07; doi: 10.3233/CBM-210232. Epub 2021 Sep 07.

PURPOSE: To explore the exact molecular mechanisms underline osteosarcoma (OS) patients with lung metastases.METHODS: The differentially expressed gene (DEG) as well as differentially expressed miRNAs (DEMs) for OS lung metastases were deeply investigated with two independent sources of databases...

High Serum Alkaline Phosphatase Flare after First-Line Androgen Deprivation Therapy Predicts Poor Prognosis in Metastatic Prostate Cancer Patients Treated with Second-Generation Androgen Receptor Targeted Therapy.

Prostate cancer

Kojima S, Masuda H, Suyama T, Hou K, Mikami K, Araki K, Naya Y.
PMID: 33898066
Prostate Cancer. 2021 Apr 08;2021:5574067. doi: 10.1155/2021/5574067. eCollection 2021.

OBJECTIVES: To determine whether an alkaline phosphatase (ALP) flare after androgen deprivation therapy (ADT) is associated with the treatment response in castration-resistant prostate cancer (CRPC) and predicts the prognosis of metastatic prostate cancer (PCa) patients.METHODS: One hundred and nineteen...

The impact of donor breast milk on metabolic bone disease, postnatal growth, and neurodevelopmental outcomes at 18 months' corrected age.

JPEN. Journal of parenteral and enteral nutrition

Kazmi SH, Berman S, Caprio M, Wachtel EV.
PMID: 33909915
JPEN J Parenter Enteral Nutr. 2021 Apr 28; doi: 10.1002/jpen.2132. Epub 2021 Apr 28.

BACKGROUND: Preterm infants are at risk for metabolic bone disease (MBD). Analysis of donor breast milk (DBM) shows lower levels of macronutrients compared with mother's own milk (MOM). The purpose of this study was to investigate the prevalence of...

Effects of different concentrations and types of microplastics on bacteria and fungi in alkaline soil.

Ecotoxicology and environmental safety

Fan P, Tan W, Yu H.
PMID: 34890986
Ecotoxicol Environ Saf. 2021 Dec 07;229:113045. doi: 10.1016/j.ecoenv.2021.113045. Epub 2021 Dec 07.

The threat of microplastic (MP) pollution of soil ecosystems has aroused global concern; however, relatively few studies have focused on the effects of MPs on both bacterial and fungal communities in soil. In this study, a 310-day soil incubation...

Real-world prognostic factors for survival among treated patients with metastatic pancreatic ductal adenocarcinoma.

Cancer medicine

Yu KH, Ozer M, Cockrum P, Surinach A, Wang S, Chu BC.
PMID: 34811961
Cancer Med. 2021 Dec;10(24):8934-8943. doi: 10.1002/cam4.4415. Epub 2021 Nov 22.

BACKGROUND: Many real-world studies of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) are restricted to single centers, limiting the generalizability of their insights. This study aimed to identify important population-based predictors for survival in patients diagnosed with mPDAC in...

Fenofibrate attenuates ischemia reperfusion-induced acute kidney injury and associated liver dysfunction in rats.

Drug development research

Kaur J, Kaur T, Sharma AK, Kaur J, Yadav HN, Pathak D, Singh AP.
PMID: 33226649
Drug Dev Res. 2021 May;82(3):412-421. doi: 10.1002/ddr.21764. Epub 2020 Nov 23.

Ischemia/reperfusion (I/R) is one of the common reasons for acute kidney injury (AKI) and we need to develop effective therapies for treating AKI. We investigated the role of fenofibrate against I/R-induced AKI and associated hepatic dysfunction in rats. In...

Prenatal enzyme replacement therapy for .

Regenerative therapy

Hasegawa A, Nakamura-Takahashi A, Kasahara M, Saso N, Narisawa S, Millán JL, Samura O, Sago H, Okamoto A, Umezawa A.
PMID: 34277899
Regen Ther. 2021 Jul 05;18:168-175. doi: 10.1016/j.reth.2021.06.002. eCollection 2021 Dec.

Hypophosphatasia (HPP) is a congenital skeletal disease. Impairment of bone mineralization and seizures are due to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP). Enzyme replacement therapy (ERT) is available as a highly successful treatment for pediatric-onset HPP. However, the...

Application of Engineered Bacteriophage T7 in the Detection of Bacteria in Food Matrices.

Frontiers in microbiology

Wisuthiphaet N, Yang X, Young GM, Nitin N.
PMID: 34421846
Front Microbiol. 2021 Aug 06;12:691003. doi: 10.3389/fmicb.2021.691003. eCollection 2021.

Detection of pathogens in a food matrix is challenging due to various constraints including complexity and the cost of sample preparation for microbial analysis from food samples, time period for the detection of pathogens, and high cost and specialized...

Alkaline phosphatase (alp) levels in multiple myeloma and solid cancers with bone lesions: Is there any difference?.

Journal of bone oncology

Annibali O, Petrucci MT, Santini D, Bongarzoni V, Russano M, Pisani F, Venditti O, Pantano F, Rago A, Siniscalchi A, Cerchiara E, Franceschini L, De Rosa L, Mariani M, Andriani S, Cudillo L, Garcia M, Cantonetti M, Mohamed S, Anaclerico B, Caravita T, Stocchi F, Cimino G, Gumenyuk S, Vozella F, Avvisati G.
PMID: 33304804
J Bone Oncol. 2020 Nov 18;26:100338. doi: 10.1016/j.jbo.2020.100338. eCollection 2021 Feb.

INTRODUCTION: Bone involvement in Multiple Myeloma results from increased osteoclast formation and activity that occurs in proximity to myeloma cells. The role of Alkaline Phosphatse (ALP) in this process and the diagnostic significance of plasma levels in patients with...

Collagen and nano-hydroxyapatite interactions in alginate-based microcapsule provide an appropriate osteogenic microenvironment for modular bone tissue formation.

Carbohydrate polymers

Hassani A, Khoshfetrat AB, Rahbarghazi R, Sakai S.
PMID: 34893227
Carbohydr Polym. 2022 Feb 01;277:118807. doi: 10.1016/j.carbpol.2021.118807. Epub 2021 Oct 30.

The addition of nano-hydroxyapatite (nHA) and collagen (Col) to the alginate (Alg) microcapsule hydrogel reduced swelling and degradation ratios while the compressive strength increased compared to Alg, Alg-Col, and Alg-nHA groups. MTT assay and Calcein-AM staining revealed an enhanced...

Treadmill exercise influences the microRNA profiles in the bone tissues of mice.

Experimental and therapeutic medicine

Yang H, Cao Z, Wang Y, Wang J, Gao J, Han B, Yu F, Qin Y, Guo Y.
PMID: 34373721
Exp Ther Med. 2021 Sep;22(3):1035. doi: 10.3892/etm.2021.10467. Epub 2021 Jul 19.

As an important regulator involved in cell activity, microRNAs (miRNAs) are important in the process of exercise influencing bone metabolism. The present study aimed to detect and select differentially expressed miRNAs in the bone tissues of mice trained on...

Showing 5905 to 5916 of 5931 entries