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Showing 13 to 24 of 75 entries
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Cerebellar mitochondrial dysfunction and concomitant multi-system fatty acid oxidation defects are sufficient to discriminate PTSD-like and resilient male mice.

Brain, behavior, & immunity - health

Preston G, Emmerzaal T, Kirdar F, Schrader L, Henckens M, Morava E, Kozicz T.
PMID: 34589865
Brain Behav Immun Health. 2020 Jul 08;6:100104. doi: 10.1016/j.bbih.2020.100104. eCollection 2020 Jul.

The impact of trauma on mental health is complex with poorly understood underlying mechanisms. Mitochondrial dysfunction is increasingly implicated in psychopathologies and mood disorders, including post-traumatic stress disorder (PTSD). We hypothesized that defects in mitochondrial energy metabolism in the...

Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort.

BMC medicine

His M, Viallon V, Dossus L, Schmidt JA, Travis RC, Gunter MJ, Overvad K, Kyrø C, Tjønneland A, Lécuyer L, Rothwell JA, Severi G, Johnson T, Katzke V, Schulze MB, Masala G, Sieri S, Panico S, Tumino R, Macciotta A, Boer JMA, Monninkhof EM, Olsen KS, Nøst TH, Sandanger TM, Agudo A, Sánchez MJ, Amiano P, Colorado-Yohar SM, Ardanaz E, Vidman L, Winkvist A, Heath AK, Weiderpass E, Huybrechts I, Rinaldi S.
PMID: 34886862
BMC Med. 2021 Dec 10;19(1):312. doi: 10.1186/s12916-021-02183-2.

BACKGROUND: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with...

Retention of acetylcarnitine in chronic kidney disease causes insulin resistance in skeletal muscle.

Journal of clinical biochemistry and nutrition

Miyamoto Y, Miyazaki T, Honda A, Shimohata H, Hirayama K, Kobayashi M.
PMID: 27895387
J Clin Biochem Nutr. 2016 Nov;59(3):199-206. doi: 10.3164/jcbn.15-146. Epub 2016 Oct 19.

Insulin resistance occurs frequently in patients with chronic kidney disease. However, the mechanisms of insulin resistance associated with chronic kidney disease are unclear. It is known that an increase in the mitochondrial acetyl-CoA (AcCoA)/CoA ratio causes insulin resistance in...

Poor Efficacy of L-Acetylcarnitine in the Treatment of Asthenozoospermia in Patients with Type 1 Diabetes.

Journal of clinical medicine

Condorelli RA, Calogero AE, Cannarella R, Giacone F, Mongioi' LM, Cimino L, Aversa A, La Vignera S.
PMID: 31035375
J Clin Med. 2019 Apr 28;8(5). doi: 10.3390/jcm8050585.

No abstract available.

Changes in Bull Semen Metabolome in Relation to Cryopreservation and Fertility.

Animals : an open access journal from MDPI

Longobardi V, Kosior MA, Pagano N, Fatone G, Staropoli A, Vassetti A, Vinale F, Campanile G, Gasparrini B.
PMID: 32575657
Animals (Basel). 2020 Jun 19;10(6). doi: 10.3390/ani10061065.

Semen cryopreservation determines several sperm damages, including the loss of fertility-associated proteins. The purpose of the study was to compare the metabolite contents in bovine sperm and seminal plasma before and after cryopreservation, and between high- and low-fertility bulls...

Carnitine Profile and Effect of Suppletion in Children with Renal Fanconi Syndrome due to Cystinosis.

JIMD reports

Besouw M, Cornelissen E, Cassiman D, Kluijtmans L, van den Heuvel L, Levtchenko E.
PMID: 24798266
JIMD Rep. 2014;16:25-30. doi: 10.1007/8904_2014_312. Epub 2014 May 06.

BACKGROUND: Cystinosis is an autosomal recessive disorder marked by intralysosomal cystine accumulation. Patients present with generalized proximal tubular dysfunction called renal Fanconi syndrome. Urinary carnitine loss results in plasma and muscle carnitine deficiency, but no clinical signs of carnitine...

Azithromycin in chronic fatigue syndrome (CFS), an analysis of clinical data.

Journal of translational medicine

Vermeulen RC, Scholte HR.
PMID: 16911783
J Transl Med. 2006 Aug 15;4:34. doi: 10.1186/1479-5876-4-34.

BACKGROUND: CFS is a clinical state with defined symptoms, but undefined cause. The patients may show a chronic state of immune activation and treatment with an antibiotic in this subgroup has been suggested.METHODS: In a retrospective study, the response...

The Effect of LC-MS Data Preprocessing Methods on the Selection of Plasma Biomarkers in Fed vs. Fasted Rats.

Metabolites

Gürdeniz G, Kristensen M, Skov T, Dragsted LO.
PMID: 24957369
Metabolites. 2012 Jan 18;2(1):77-99. doi: 10.3390/metabo2010077.

The metabolic composition of plasma is affected by time passed since the last meal and by individual variation in metabolite clearance rates. Rat plasma in fed and fasted states was analyzed with liquid chromatography quadrupole-time-of-flight mass spectrometry (LC-QTOF) for...

The two β-oxidation sites in pea cotyledons : Carnitine palmitoyltransferase: location and function in pea mitochondria.

Planta

Thomas DR, Wood C.
PMID: 24232030
Planta. 1986 Jun;168(2):261-6. doi: 10.1007/BF00402972.

Two sites for β-oxidation of fatty acids in pea (Pisum sativum L.) cotyledons exist. One site is the microbody, the other the mitochondrion. Mitochondrial β-oxidation of fatty acids is carnitine-dependent. The fatty acid permeates the membrane as palmitoylcarnitine which...

Unveiling differences between patients with acute coronary syndrome with and without ST elevation through fingerprinting with CE-MS and HILIC-MS targeted analysis.

Electrophoresis

Naz S, Calderón ÁA, García A, Gallafrio J, Mestre RT, González EG, de Cabo CM, Delgado MCM, Balanza JÁL, Simionato AVC, Vaeza NN, Barbas C, Rupérez FJ.
PMID: 26177736
Electrophoresis. 2015 Sep;36(18):2303-2313. doi: 10.1002/elps.201500169. Epub 2015 Aug 27.

Differences in the degree and severity of Acute Coronary Syndrome, associated to differences in the electrocardiogram, together with blood tests of biomarkers classify patients for diagnosis and treatment. Cases where the electrocardiogram and/or biomarkers are not conclusive still appear,...

An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder.

Molecular psychiatry

Pu J, Liu Y, Zhang H, Tian L, Gui S, Yu Y, Chen X, Chen Y, Yang L, Ran Y, Zhong X, Xu S, Song X, Liu L, Zheng P, Wang H, Xie P.
PMID: 31959849
Mol Psychiatry. 2021 Aug;26(8):4265-4276. doi: 10.1038/s41380-020-0645-4. Epub 2020 Jan 20.

Major depressive disorder (MDD) is a serious mental illness, characterized by high morbidity, which has increased in recent decades. However, the molecular mechanisms underlying MDD remain unclear. Previous studies have identified altered metabolic profiles in peripheral tissues associated with...

Serum-based metabolic alterations in patients with papillary thyroid carcinoma unveiled by non-targeted 1H-NMR metabolomics approach.

Iranian journal of basic medical sciences

Farrokhi Yekta R, Rezaei Tavirani M, Arefi Oskouie A, Mohajeri-Tehrani MR, Soroush AR, Akbarzadeh Baghban A.
PMID: 30483387
Iran J Basic Med Sci. 2018 Nov;21(11):1140-1147. doi: 10.22038/IJBMS.2018.30375.7323.

OBJECTIVES: As the most prevalent endocrine system malignancy, papillary thyroid carcinoma had a very fast rising incidence in recent years for unknown reasons besides the fact that the current methods in thyroid cancer diagnosis still hold some limitations. Therefore,...

Showing 13 to 24 of 75 entries