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Wynne-Davies R, Lloyd-Roberts GC. Arthrogryposis multiplex congenita. Search for prenatal factors in 66 sporadic cases. Arch Dis Child. 1976;51(8):618-23doi: 10.1136/adc.51.8.618.
Wynne-Davies, R., & Lloyd-Roberts, G. C. (1976). Arthrogryposis multiplex congenita. Search for prenatal factors in 66 sporadic cases. Archives of disease in childhood, 51(8), 618-23. https://doi.org/10.1136/adc.51.8.618
Wynne-Davies, R, and Lloyd-Roberts, G C. "Arthrogryposis multiplex congenita. Search for prenatal factors in 66 sporadic cases." Archives of disease in childhood vol. 51,8 (1976): 618-23. doi: https://doi.org/10.1136/adc.51.8.618
Wynne-Davies R, Lloyd-Roberts GC. Arthrogryposis multiplex congenita. Search for prenatal factors in 66 sporadic cases. Arch Dis Child. 1976 Aug;51(8):618-23. doi: 10.1136/adc.51.8.618. PMID: 962372; PMCID: PMC1546116.
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Arch Dis Child. 1976 Aug;51(8):618-23. doi: 10.1136/adc.51.8.618.

Arthrogryposis multiplex congenita. Search for prenatal factors in 66 sporadic cases.

Archives of disease in childhood

R Wynne-Davies, G C Lloyd-Roberts

PMID: 962372 PMCID: PMC1546116 DOI: 10.1136/adc.51.8.618
Free PMC Article

Abstract

In a family and epidemiological survey of 66 cases of arthrogryposis multiplex congenita all cases were found to be sporadic and no family association with clubfoot, congenital dislocation of the hip, or hereditary neuromuscular disease was found. The mothers were significantly older than average. Oligohydramnios was noted in only one-third of cases but many other complications of pregnancy, including probable attempts at abortion, had occurred. It is likely that most cases of arthrogryposis are nongenetic and result from a defective intrauterine environment, whether hormonal, vascular, mechanical, or possibly infective.

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