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de Repentigny L, Hanasono GK, Plaa GL. The influence of acute diazepam pretreatment on the action and disposition of [14C]pentobarbital in rats. Can J Physiol Pharmacol. 1976;54(5):671-4doi: 10.1139/y76-093.
de Repentigny, L., Hanasono, G. K., & Plaa, G. L. (1976). The influence of acute diazepam pretreatment on the action and disposition of [14C]pentobarbital in rats. Canadian journal of physiology and pharmacology, 54(5), 671-4. https://doi.org/10.1139/y76-093
de Repentigny, L, et al. "The influence of acute diazepam pretreatment on the action and disposition of [14C]pentobarbital in rats." Canadian journal of physiology and pharmacology vol. 54,5 (1976): 671-4. doi: https://doi.org/10.1139/y76-093
de Repentigny L, Hanasono GK, Plaa GL. The influence of acute diazepam pretreatment on the action and disposition of [14C]pentobarbital in rats. Can J Physiol Pharmacol. 1976 Oct;54(5):671-4. doi: 10.1139/y76-093. PMID: 990998.
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Can J Physiol Pharmacol. 1976 Oct;54(5):671-4. doi: 10.1139/y76-093.

The influence of acute diazepam pretreatment on the action and disposition of [14C]pentobarbital in rats.

Canadian journal of physiology and pharmacology

L de Repentigny, G K Hanasono, G L Plaa

PMID: 990998 DOI: 10.1139/y76-093

Abstract

Diazepam (DZP) pretreatment (100mg/kg, ip) of rats 6 h before pentobarbital administration (45 mg/kg, ip) prolonged the barbiturate-induced narcosis. The concentrations of [14C]pentobarbital and total pentobarbital derivatives in blood or brain showed no differences between control and DZP-pretreated animals. The brain and blood concentrations of pentobarbital, when measured at a time corresponding to the respective arousal times from pentobarbital narcosis, were lower in the DZP-pretreated group. These results indicate that acute DZP pretreatment increases the sensitivity of the rat brain to pentobarbital rather than inducing changes in the disposition of the barbiturate.

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