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Harvey SA, Hung RT, Millen SJ. Vestibular compensation in guinea pigs given intravenous lidocaine after unilateral labyrinthectomy. Otolaryngol Head Neck Surg. 1999;120(1):12-6doi: 10.1016/S0194-5998(99)70363-3.
Harvey, S. A., Hung, R. T., & Millen, S. J. (1999). Vestibular compensation in guinea pigs given intravenous lidocaine after unilateral labyrinthectomy. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 120(1), 12-6. https://doi.org/10.1016/S0194-5998(99)70363-3
Harvey, S A, et al. "Vestibular compensation in guinea pigs given intravenous lidocaine after unilateral labyrinthectomy." Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery vol. 120,1 (1999): 12-6. doi: https://doi.org/10.1016/S0194-5998(99)70363-3
Harvey SA, Hung RT, Millen SJ. Vestibular compensation in guinea pigs given intravenous lidocaine after unilateral labyrinthectomy. Otolaryngol Head Neck Surg. 1999 Jan;120(1):12-6. doi: 10.1016/S0194-5998(99)70363-3. PMID: 9914543.
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Otolaryngol Head Neck Surg. 1999 Jan;120(1):12-6. doi: 10.1016/S0194-5998(99)70363-3.

Vestibular compensation in guinea pigs given intravenous lidocaine after unilateral labyrinthectomy.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

S A Harvey, R T Hung, S J Millen

Affiliations

  1. Department of Otolaryngology and Human Communication, Medical College of Wisconsin, Milwaukee 53226, USA.

PMID: 9914543 DOI: 10.1016/S0194-5998(99)70363-3

Abstract

Intravenous lidocaine has been reported to alleviate vertigo in Meniere's disease and suggested as a possible antivertigo agent after unilateral labyrinthectomy in a study of cats. To further evaluate the effects of intravenous lidocaine on the acute phase of postural compensation, we subjected 13 pigmented guinea pigs to unilateral labyrinthectomy. Seven received intravenous lidocaine (4 mg/kg) immediately after labyrinthectomy. The other six served as controls and received an equivalent-volume injection of normal saline solution. Total body curvature, trunk curvature, yaw head tilt, and roll head tilt were measured at frequent intervals for up to 30 hours after surgery. Both groups had immediate difficulties with posturing that gradually improved. The lidocaine group tended to exhibit delayed postural compensation, but this was only statistically significant for roll head tilt. These results do not show improvement in postural compensation from unilateral labyrinthectomy after the administration of intravenous lidocaine. A species-specific effect on the vestibular pathways is suggested, and we conclude that further evaluation of lidocaine and the vestibular system is warranted.

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