Pharmazie. 1998 May;53(5):334-6.

Iontophoretic transdermal delivery of salbutamol: methyl-orange ion-pair.

Die Pharmazie

V P Sant, A J Khopade, N K Jain

PMID: 9631502

Abstract

The influence of pulsed current duty cycle, addition of electrically neutral species and pH on iontophoretic transdermal delivery of an organic ion-pair salbutamol:methyl orange through excised rabbit abdominal skin is described. It was compared with salbutamol sulphate and salbutamol:sulphate ion-pair. It was found that there exists an optimum duty cycle range (1:3-1:4) at which iontophoretic flux of the ion-pair was at a maximum because of partition-electric current synchronization. Addition of mannitol decreases the flux of the ion-pair showing the important role of electroosmosis in ion-pair transport. The extremes of pH decrease the flux rates.

Substances

• Adrenergic alpha-Antagonists
• Azo Compounds
• Indicators and Reagents
• Mannitol
• methyl orange
• Albuterol

MeSH terms

• Administration, Cutaneous
• Adrenergic alpha-Antagonists / administration & dosage
• Adrenergic alpha-Antagonists / chemistry
• Adrenergic alpha-Antagonists / pharmacokinetics
• Albuterol / administration & dosage
• Albuterol / chemistry
• Albuterol / pharmacokinetics
• Animals
• Azo Compounds / chemistry
• Hydrogen-Ion Concentration
• In Vitro Techniques
• Indicators and Reagents
• Ion Exchange
• Iontophoresis
• Mannitol / chemistry
• Permeability
• Rabbits
• Skin Absorption

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't