Proc Soc Exp Biol Med. 1975 Sep;149(4):903-7. doi: 10.3181/00379727-149-38924.

Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

G K Hanasono, H Witschi, G L Plaa

PMID: 1166087 DOI: 10.3181/00379727-149-38924

Abstract

Alloxan diabetes enhances the hepatotoxic response of male rats to chloroform and 1, 1, 2-trichloroethane, but not to trichloroethylene nor 1, 1, 1-trichloroethane. Insulin treatment partially protects the animals against the alloxan-induced enhancement of chloroform hepatotoxicity. Alloxan diabetes also enhances the hepatotoxic response to galactosamine but not to beryllium nor alpha-naphthylisothiocyanate.

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Substances

• Blood Glucose
• Hydrocarbons, Chlorinated
• Insulin
• Triglycerides
• Trichloroethylene
• 1-Naphthylisothiocyanate
• Galactosamine
• Chloroform
• Isocitrate Dehydrogenase
• Alanine Transaminase
• Ethane
• Bilirubin

MeSH terms

• 1-Naphthylisothiocyanate / pharmacology
• Alanine Transaminase / blood
• Animals
• Bilirubin / blood
• Blood Glucose
• Chemical and Drug Induced Liver Injury* / physiopathology
• Chloroform / toxicity
• Diabetes Mellitus, Experimental / physiopathology
• Ethane / analogs & derivatives
• Ethane / toxicity
• Galactosamine / pharmacology
• Hydrocarbons, Chlorinated / toxicity
• Insulin / pharmacology
• Isocitrate Dehydrogenase / blood
• Liver / analysis
• Liver / physiopathology
• Male
• Rats
• Trichloroethylene / toxicity
• Triglycerides / analysis

Publication Types

• Journal Article

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