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De Vecchi E, Pala MG, Di Credico G, et al. Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery. Heart. 1998;79(3):242-7doi: 10.1136/hrt.79.3.242.
De Vecchi, E., Pala, M. G., Di Credico, G., Agape, V., Paolini, G., Bonini, P. A., Grossi, A., & Paroni, R. (1998). Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery. Heart (British Cardiac Society), 79(3), 242-7. https://doi.org/10.1136/hrt.79.3.242
De Vecchi, E, et al. "Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery." Heart (British Cardiac Society) vol. 79,3 (1998): 242-7. doi: https://doi.org/10.1136/hrt.79.3.242
De Vecchi E, Pala MG, Di Credico G, Agape V, Paolini G, Bonini PA, Grossi A, Paroni R. Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery. Heart. 1998 Mar;79(3):242-7. doi: 10.1136/hrt.79.3.242. PMID: 9602656; PMCID: PMC1728633.
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Heart. 1998 Mar;79(3):242-7. doi: 10.1136/hrt.79.3.242.

Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery.

Heart (British Cardiac Society)

E De Vecchi, M G Pala, G Di Credico, V Agape, G Paolini, P A Bonini, A Grossi, R Paroni

Affiliations

  1. Department of Laboratory Medicine, IRCCS H San Raffaele, Milan, Italy.

PMID: 9602656 PMCID: PMC1728633 DOI: 10.1136/hrt.79.3.242
Free PMC Article

Abstract

OBJECTIVE: To determine whether preoperative left ventricular ejection fraction (LVEF) is related to the degree of myocardial oxidative stress during bypass surgery in man.

DESIGN: Observational study.

SETTING: Tertiary care centre.

PATIENTS AND INTERVENTIONS: 31 patients (LVEF range was 20% to 68%) undergoing elective coronary bypass surgery with blood cardioplegic reperfusion were studied. Arterial and coronary sinus blood was collected before aortic cross clamping (T0) and at 0 (T1), 15 (T2), and 30 (T3) minutes after unclamping. Transmural left ventricular biopsies were also obtained from 15 patients at T0 and at T1.

MAIN OUTCOME MEASURES: Glutathione and adenine nucleotides were measured in myocardial biopsies, while coronary sinus-artery differences for glutathione, nucleotides, and products of lipid peroxidation were calculated from blood specimens. Creatine kinase (myocardial band; CK-MB) was measured in plasma at four and 12 hours after operation.

RESULTS: Myocardial glutathione and adenine nucleotides were correlated (p < 0.02) with preoperative LVEF both at T0 (r = 0.909 and 0.672) and T1 (r = 0.603 and 0.605). Oxidised glutathione released from the heart during reperfusion was inversely correlated with LVEF (r = -0.448, -0.466, and -0461 at T1, T2, and T3, p < 0.01), while reduced glutathione (r = 0.519 and 0.640 at T1 and T2) and glutathione redox ratio (r = 0.647, 0.714, 0.645, and 0.702 at T0, T1, T2, and T3) showed a direct correlation (p < 0.01). Lipid peroxidation at T1 was negatively related to LVEF (r = -0.492). CK-MB was also negatively related to LVEF (r = -0.440 at 4 h and -0.462 at 12 h).

CONCLUSIONS: The capacity to counterbalance oxidative burst following ischaemia and reperfusion appears to be related to the functional ability of the heart.

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References

  1. Circulation. 1983 Oct;68(4):785-95 - PubMed
  2. Heart. 1997 May;77(5):449-55 - PubMed
  3. N Engl J Med. 1985 Jan 17;312(3):159-63 - PubMed
  4. J Thorac Cardiovasc Surg. 1983 Oct;86(4):519-27 - PubMed
  5. Am Heart J. 1981 Jan;101(1):59-66 - PubMed
  6. J Clin Invest. 1985 Aug;76(2):517-27 - PubMed
  7. J Thorac Cardiovasc Surg. 1987 Jan;93(1):127-39 - PubMed
  8. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1404-7 - PubMed
  9. J Lab Clin Med. 1987 Jul;110(1):13-30 - PubMed
  10. Prog Cardiovasc Dis. 1987 Jul-Aug;30(1):23-44 - PubMed
  11. J Clin Invest. 1988 Aug;82(2):476-85 - PubMed
  12. J Mol Cell Cardiol. 1989 Jul;21(7):691-5 - PubMed
  13. Circulation. 1990 Jan;81(1):201-11 - PubMed
  14. Am J Cardiol. 1990 May 15;65(18):1261-2 - PubMed
  15. Circulation. 1990 Sep;82(3):723-38 - PubMed
  16. J Card Surg. 1989 Sep;4(3):216-38 - PubMed
  17. Cardiovasc Res. 1992 Jul;26(7):641-55 - PubMed
  18. J Thorac Cardiovasc Surg. 1993 Aug;106(2):268-74 - PubMed
  19. Ann Thorac Surg. 1993 Dec;56(6):1315-23 - PubMed
  20. J Thorac Cardiovasc Surg. 1994 Jan;107(1):248-56 - PubMed
  21. Eur Heart J. 1993 Nov;14(11):1493-8 - PubMed
  22. Circulation. 1994 Jul;90(1):291-7 - PubMed
  23. Cardiovasc Surg. 1994 Feb;2(1):88-92 - PubMed
  24. Clin Chem. 1995 Mar;41(3):448-54 - PubMed
  25. Cardiovasc Res. 1995 Jan;29(1):118-25 - PubMed
  26. J Thorac Cardiovasc Surg. 1995 Apr;109(4):787-95 - PubMed
  27. Eur J Pharmacol. 1995 Dec 29;294(2-3):737-42 - PubMed

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