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Pharm World Sci. 1997 Oct;19(5):251-2. doi: 10.1023/a:1008605208941.

Calcium dobesilate-induced agranulocytosis.

Pharmacy world & science : PWS

E García Benayas, B García Díaz, G Pérez


  1. Severo Ochoa Hospital, Madrid, Spain.

PMID: 9368927 DOI: 10.1023/a:1008605208941


Here we report a case of a patient in whom the administration of calcium dobesilate was associated with the development of an agranulocytosis episode. Eight weeks after the beginning of the treatment he was hospitalized with fever and leucopenia. Bone marrow biopsy showed a maturative promyelocytic interruption. All medication was withdrawn and blood cell count was completely recovered 7 days after admission. G-CSF was administered. A detailed study was performed and causal relationship was not suggestive for the other three drugs the patient was receiving. To date, there have only been reported two cases of calcium dobesilate induced agranulocytosis.


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