Drug Saf. 1997 Sep;17(3):197-207. doi: 10.2165/00002018-199717030-00005.

Drug-induced uveitis. Incidence, prevention and treatment.

Drug safety

F W Fraunfelder, J T Rosenbaum

PMID: 9306054 DOI: 10.2165/00002018-199717030-00005

Abstract

Drug-induced uveitis is a relatively rare occurrence. For example, the patient database at the tertiary referral Uveitis Clinic at the Casey Eye Institute, Oregon Health Sciences University records an incidence of less than 0.5%. Despite this, the frequency of uveitis secondary to rifabutin therapy in AIDS patients has brought greater recognition to the potential role of medications as a cause of intraocular inflammation. A brief review of uveitis including its classification, causes, symptoms and signs is presented along with a review of systemic medications associated with uveitis. These medications include cidofovir, cobalt, diethylcarbamazepine, pamidronic acid (disodium pamidronate), interleukin-3 and interleukin-6, oral contraceptives, quinidine, rifabutin, streptokinase and sulfonamides. Other systemic medications may cause uveitis. Topical ocular medications such as beta-blockers and corticosteroids as well as other topical ocular medications have been associated with uveitis. Cidofovir, pamidronic acid, sulfonamides, rifabutin and topical metipranolol can 'probably' cause uveitis. The remainder of the medications discussed have a 'possible' cause-and-effect relationship with uveitis. Treatment begins with recognition of a drug-related event and usually subsequent avoidance of the drug. Therapy depends on the severity and likelihood of the reaction. Drug-induced uveitis is almost always reversible within weeks of discontinuation of the drug and treatment of the inflammation.

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References

1. Br J Clin Pract. 1995 Sep-Oct;49(5):272-3 - PubMed
2. Ann Pharmacother. 1995 Nov;29(11):1149-55 - PubMed
3. N Engl J Med. 1994 Feb 10;330(6):438-9 - PubMed
4. Arch Ophthalmol. 1996 May;114(5):604-5 - PubMed
5. Br J Ophthalmol. 1991 Sep;75(9):575 - PubMed
6. Ann Intern Med. 1996 Jul 15;125(2):98-103 - PubMed
7. Ophthalmology. 1980 May;87(5):447-50 - PubMed
8. Br J Ophthalmol. 1991 Sep;75(9):519-23 - PubMed
9. AIDS. 1990 May;4(5):433-41 - PubMed
10. Invest Ophthalmol Vis Sci. 1990 May;31(5):917-20 - PubMed
11. Ophthalmology. 1996 Nov;103(11):1916-24 - PubMed
12. Arch Ophthalmol. 1991 Jan;109(1):67-9 - PubMed
13. Lancet. 1969 Jul 5;2(7610):27-8 - PubMed
14. Am J Ophthalmol. 1994 Dec 15;118(6):716-22 - PubMed
15. Am J Ophthalmol. 1974 Apr;77(4):433-7 - PubMed
16. Arch Ophthalmol. 1995 Apr;113(4):408-9 - PubMed
17. N Engl J Med. 1994 May 5;330(18):1315-6 - PubMed
18. Drugs. 1996 Aug;52(2):225-230; discussion 231 - PubMed
19. Ann Intern Med. 1994 Oct 1;121(7):510-2 - PubMed
20. N Engl J Med. 1994 Mar 24;330(12):868 - PubMed
21. Cardiology. 1991;78(1):68-71 - PubMed
22. Eye (Lond). 1994;8 ( Pt 6):708-9 - PubMed
23. Arch Ophthalmol. 1996 May;114(5):593-9 - PubMed
24. Am J Ophthalmol. 1991 Oct 15;112(4):461-2 - PubMed
25. Arch Ophthalmol. 1994 Oct;112(10):1277 - PubMed
26. Trans Ophthalmol Soc U K. 1971;91:561-74 - PubMed
27. Br J Rheumatol. 1995 May;34(5):479 - PubMed
28. Adv Pharmacol Chemother. 1979;16:129-94 - PubMed
29. Eye (Lond). 1992;6 ( Pt 3):277-9 - PubMed
30. Am J Ophthalmol. 1982 Mar;93(3):368-9 - PubMed
31. Arch Ophthalmol. 1993 Dec;111(12):1606-7 - PubMed
32. Am J Ophthalmol. 1994 Aug 15;118(2):220-4 - PubMed
33. Lancet. 1993 Feb 13;341(8842):436-7 - PubMed
34. Aust N Z J Med. 1994 Jun;24(3):320 - PubMed
35. Am J Ophthalmol. 1994 Dec 15;118(6):712-5 - PubMed
36. Br J Ophthalmol. 1981 Jul;65(7):494-502 - PubMed
37. J Glaucoma. 1993 Fall;2(3):166-70 - PubMed
38. Lancet. 1992 May 9;339(8802):1175-6 - PubMed
39. Br J Ophthalmol. 1995 Nov;79(11):970-1 - PubMed
40. Am J Ophthalmol. 1996 Oct;122(4):580-2 - PubMed
41. Am J Ophthalmol. 1970 Dec;70(6):883-5 - PubMed
42. Invest Ophthalmol Vis Sci. 1991 Jan;32(1):88-95 - PubMed
43. Ann Pharmacother. 1996 Jan;30(1):43-54 - PubMed
44. Arch Ophthalmol. 1994 Sep;112(9):1159-65 - PubMed
45. Clin Pharmacol Ther. 1981 Aug;30(2):239-45 - PubMed
46. Arch Ophthalmol. 1965 Nov;74(5):628-40 - PubMed
47. Am J Ophthalmol. 1988 May 15;105(5):534-7 - PubMed
48. BMJ. 1994 Jul 9;309(6947):97 - PubMed
49. Br J Ophthalmol. 1992 Mar;76(3):137-41 - PubMed
50. Arch Ophthalmol. 1996 Aug;114(8):929-32 - PubMed
51. Ophthalmology. 1996 Jul;103(7):999-1000 - PubMed
52. N Engl J Med. 1994 Feb 24;330(8):576-7 - PubMed
53. Isr J Med Sci. 1992 Oct;28(10 ):741-3 - PubMed
54. Surgery. 1974 Nov;76(5):771-8 - PubMed
55. Semin Arthritis Rheum. 1990 Feb;19(4):248-57 - PubMed
56. Clin Infect Dis. 1996 Apr;22 Suppl 1:S43-7; discussion S47-9 - PubMed
57. BMJ. 1992 Nov 28;305(6865):1332 - PubMed
58. Surv Ophthalmol. 1983 Dec;28 Suppl:243-51 - PubMed
59. Arch Ophthalmol. 1979 Oct;97(10):1993 - PubMed
60. N Engl J Med. 1979 Dec 6;301(23):1266-70 - PubMed
61. Clin Nephrol. 1980 Apr;13(4):151-4 - PubMed
62. Arch Ophthalmol. 1996 Oct;114(10):1181-2 - PubMed
63. Drugs. 1994 Jun;47(6):983-1009 - PubMed
64. Drugs. 1988 Nov;36(5):601-15 - PubMed
65. Pediatr Infect Dis J. 1995 Mar;14(3):246-7 - PubMed
66. N Engl J Med. 1984 Mar 1;310(9):563-72 - PubMed
67. Drugs. 1991 Dec;42(6):919-44 - PubMed

MeSH terms

• Causality
• Humans
• Incidence
• Nephritis, Interstitial / complications
• Uveitis / chemically induced
• Uveitis / complications
• Uveitis / etiology
• Uveitis / therapy

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't
• Research Support, U.S. Gov't, P.H.S.
• Review

Grant support

• EY 06484/EY/NEI NIH HHS/United States

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