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van Roon JA, van Eden W, van Roy JL, et al. Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis. J Clin Invest. 1997;100(2):459-63doi: 10.1172/JCI119553.
van Roon, J. A., van Eden, W., van Roy, J. L., Lafeber, F. J., & Bijlsma, J. W. (1997). Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis. The Journal of clinical investigation, 100(2), 459-63. https://doi.org/10.1172/JCI119553
van Roon, J A, et al. "Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis." The Journal of clinical investigation vol. 100,2 (1997): 459-63. doi: https://doi.org/10.1172/JCI119553
van Roon JA, van Eden W, van Roy JL, Lafeber FJ, Bijlsma JW. Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis. J Clin Invest. 1997 Jul 15;100(2):459-63. doi: 10.1172/JCI119553. PMID: 9218524; PMCID: PMC508210.
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American Society for Clinical Investigation Free PMC Article

J Clin Invest. 1997 Jul 15;100(2):459-63. doi: 10.1172/JCI119553.

Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis.

The Journal of clinical investigation

J A van Roon, W van Eden, J L van Roy, F J Lafeber, J W Bijlsma

Affiliations

  1. Department of Rheumatology & Clinical Immunology, University Hospital Utrecht, 3508 GA Utrecht, The Netherlands.

PMID: 9218524 PMCID: PMC508210 DOI: 10.1172/JCI119553
Free PMC Article

Abstract

In several animal models of rheumatoid arthritis (RA), T cell responses to self 60-kD heat-shock protein 60 (hsp60) protect against the induction of arthritis. The nature of this suppressive T cell activity induced by self hsp60 is not clear. In the present study, T cell responses to human (self) hsp60 in RA in terms of type 1 (T1) and type 2 (T2) T cell activity were assessed. The results show that human and not bacterial hsp60-reactive synovial fluid (SF) T cells of patients with RA proliferate in the presence of the T2 cell growth factor IL-4. SF T cells stimulated with human hsp60 produced significantly lower amounts of IFN-gamma and higher amounts of IL-4 than SF T cells stimulated with bacterial hsp60 (P

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