Display options
Cite
Leach E, Howard P, Barer GR. Resolution of hypoxic changes in the heart and pulmonary arterioles of rats during intermittent correction of hypoxia. Clin Sci Mol Med. 1977;52(2):153-62doi: 10.1042/cs0520153.
Leach, E., Howard, P., & Barer, G. R. (1977). Resolution of hypoxic changes in the heart and pulmonary arterioles of rats during intermittent correction of hypoxia. Clinical science and molecular medicine, 52(2), 153-62. https://doi.org/10.1042/cs0520153
Leach, E, et al. "Resolution of hypoxic changes in the heart and pulmonary arterioles of rats during intermittent correction of hypoxia." Clinical science and molecular medicine vol. 52,2 (1977): 153-62. doi: https://doi.org/10.1042/cs0520153
Leach E, Howard P, Barer GR. Resolution of hypoxic changes in the heart and pulmonary arterioles of rats during intermittent correction of hypoxia. Clin Sci Mol Med. 1977 Feb;52(2):153-62. doi: 10.1042/cs0520153. PMID: 139224.
Copy Download .nbib Format: NLM
Share it on

Clin Sci Mol Med. 1977 Feb;52(2):153-62. doi: 10.1042/cs0520153.

Resolution of hypoxic changes in the heart and pulmonary arterioles of rats during intermittent correction of hypoxia.

Clinical science and molecular medicine

E Leach, P Howard, G R Barer

PMID: 139224 DOI: 10.1042/cs0520153

Abstract

1. Rats kept in a hypoxic chamber (10% O2) for 3 or more weeks developed right ventricular hypertrophy, muscularization of pulmonary arterioles and polycythaemia. These changes resemble those found in human hypoxic disease and, in particular, in patients dying from chronic airways obstruction. 2. Resolution of these changes was studied in a normal environment and in an intermittently normal, intermittently hypoxic environment. The latter regimen modelled the situation of patients with cor pulmonale receiving long-term intermittent oxygen therapy. 3. In a normal environment right ventricular hypertrophy and polycythaemia were resolved in 6 weeks but vessel changes were not resolved in 12 weeks. 4. In the intermittently normoxic environment (40 or 80 h in air per week) there was some resolution of right ventricular hypertrophy in 6 weeks but no significant reduction in vessel thickening or in polycythaemia in 12 weeks.

Cited by

MeSH terms

Publication Types

LinkOut - more resources