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Madden BP, Shenoy V, Dalrymple-Hay M, et al. Absence of bradycardic response to apnea and hypoxia in heart transplant recipients with obstructive sleep apnea. J Heart Lung Transplant. 1997;16(4):394-7
Madden, B. P., Shenoy, V., Dalrymple-Hay, M., Griffiths, T., Millard, J., Backhouse, L., Clarke, J., & Murday, A. (1997). Absence of bradycardic response to apnea and hypoxia in heart transplant recipients with obstructive sleep apnea. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 16(4), 394-7.
Madden, B P, et al. "Absence of bradycardic response to apnea and hypoxia in heart transplant recipients with obstructive sleep apnea." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation vol. 16,4 (1997): 394-7.
Madden BP, Shenoy V, Dalrymple-Hay M, Griffiths T, Millard J, Backhouse L, Clarke J, Murday A. Absence of bradycardic response to apnea and hypoxia in heart transplant recipients with obstructive sleep apnea. J Heart Lung Transplant. 1997 Apr;16(4):394-7. PMID: 9154949.
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J Heart Lung Transplant. 1997 Apr;16(4):394-7.

Absence of bradycardic response to apnea and hypoxia in heart transplant recipients with obstructive sleep apnea.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

B P Madden, V Shenoy, M Dalrymple-Hay, T Griffiths, J Millard, L Backhouse, J Clarke, A Murday

Affiliations

  1. Department of Cardiological Sciences, St. George's Hospital, London, United Kingdom.

PMID: 9154949

Abstract

In patients with obstructive sleep apnea, the vagal stimulation caused by inspiration against the upper airway obstruction results in sinus bradycardia during the apnea followed by a reflex tachycardia at apnea termination. We report on five heart transplant recipients with obstructive sleep apnea who demonstrated no change in baseline heart rate in spite of marked hemoglobin oxygen desaturation, presumably on account of parasympathetic denervation of the allograft. Heart transplant recipients with obstructive sleep apnea may be at an increased risk of development of potentially fatal ventricular arrhythmias if the allograft is unable to respond appropriately to hypoxia. Should cardiac parasympathetic reinnervation occur, prospective polysomnography may be a marker for this process in these patients.

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