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Lampert F, Christiansen H, Berner F, et al. Disseminated neuroblastomas under 1 year of age: cell biology and prognosis. J Neurooncol. 1997;31(1):181-4doi: 10.1023/a:1005778607661.
Lampert, F., Christiansen, H., Berner, F., Terpe, H. J., & Berthold, F. (1997). Disseminated neuroblastomas under 1 year of age: cell biology and prognosis. Journal of neuro-oncology, 31(1), 181-4. https://doi.org/10.1023/a:1005778607661
Lampert, F, et al. "Disseminated neuroblastomas under 1 year of age: cell biology and prognosis." Journal of neuro-oncology vol. 31,1 (1997): 181-4. doi: https://doi.org/10.1023/a:1005778607661
Lampert F, Christiansen H, Berner F, Terpe HJ, Berthold F. Disseminated neuroblastomas under 1 year of age: cell biology and prognosis. J Neurooncol. 1997 Jan;31(1):181-4. doi: 10.1023/a:1005778607661. PMID: 9049847.
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J Neurooncol. 1997 Jan;31(1):181-4. doi: 10.1023/a:1005778607661.

Disseminated neuroblastomas under 1 year of age: cell biology and prognosis.

Journal of neuro-oncology

F Lampert, H Christiansen, F Berner, H J Terpe, F Berthold

Affiliations

  1. Department of Pediatrics, Hematology and Oncology, University of Giessen, Germany.

PMID: 9049847 DOI: 10.1023/a:1005778607661

Abstract

Tumor specimens of 203 infants with neuroblastomas of different clinical stages-registered in successive multicenter clinical trials of the German Society of Pediatric Oncology-could be examined for N-myc amplification, chromosome 1-ploidy and-structure, CD44 std. expression (in tumor tissue, and also in patient's sera). Eighty-seven (= 43%) of these infants had a non-localized, disseminated neuroblastoma, mainly involving sympathetic nerve tissue, lymph nodes, liver, skin, bone marrow and bones (46 patients were classified into the 4 group, 41 patients in the true 4 group). If the clinical classification between stage 4 and stage 4s was neglected, then 17 of these infants (= 20%) had N-myc amplification (4-64 copies) with 16 already dead. Seven of 9 examined patients with true stage 4- had chromosome 1p aberrations (with N-myc amplification in 5), and among the dead there were 2 with CD44 negative expression. In another series, serum CD44 std. was measured by ELISA, and the highest (significantly different) Kruskal-Wallis mean rank values (147.8) were found in infants (n = 6) with stage 4s compared to the low mean-rank-value of 71.9 in patients with stage 4 (n = 65). Stage 1-3 patients (n = 42) had values of 99.8-88.6. Thus, infants with disseminated neuroblastomas, showing non-diploidy, normal chromosome 1p structure, non-N-myc amplification and high CD44 std. expression in tumor tissue, and also high CD44 std. values in serum, will have the highest chance of survival due to tumor-non-progression. On the other hand, N-myc amplification in the tumor cells was found to be characteristic for stage 4s neuroblastoma patients with tumor progression (n = 6). Therefore, 4s neuroblastoma-patients with N-myc amplified tumors should be aggressively treated like true stage 4 tumor patients.

References

  1. Hum Mol Genet. 1995 Apr;4(4):535-9 - PubMed
  2. Genes Chromosomes Cancer. 1994 Aug;10(4):275-81 - PubMed
  3. J Clin Oncol. 1993 Aug;11(8):1466-77 - PubMed
  4. Genes Chromosomes Cancer. 1994 May;10(1):30-9 - PubMed
  5. Genes Chromosomes Cancer. 1992 Sep;5(2):141-9 - PubMed
  6. Br J Cancer. 1988 Jan;57(1):121-6 - PubMed
  7. Cancer. 1994 Dec 15;74(12):3223-6 - PubMed
  8. Cancer Genet Cytogenet. 1994 Dec;78(2):242 - PubMed
  9. J Clin Oncol. 1991 Aug;9(8):1371-5 - PubMed
  10. Pediatrics. 1992 Jan;89(1):114-8 - PubMed
  11. Am J Pediatr Hematol Oncol. 1992 Aug;14(3):207-15 - PubMed
  12. Cancer. 1995 Apr 1;75(7):1694-9 - PubMed
  13. Cell Death Differ. 1994;1(2):123-8 - PubMed

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