Display options
Cite
Carpenter LL, McDougle CJ, Epperson CN, et al. A risk-benefit assessment of drugs used in the management of obsessive-compulsive disorder. Drug Saf. 1996;15(2):116-34doi: 10.2165/00002018-199615020-00004.
Carpenter, L. L., McDougle, C. J., Epperson, C. N., & Price, L. H. (1996). A risk-benefit assessment of drugs used in the management of obsessive-compulsive disorder. Drug safety, 15(2), 116-34. https://doi.org/10.2165/00002018-199615020-00004
Carpenter, L L, et al. "A risk-benefit assessment of drugs used in the management of obsessive-compulsive disorder." Drug safety vol. 15,2 (1996): 116-34. doi: https://doi.org/10.2165/00002018-199615020-00004
Carpenter LL, McDougle CJ, Epperson CN, Price LH. A risk-benefit assessment of drugs used in the management of obsessive-compulsive disorder. Drug Saf. 1996 Aug;15(2):116-34. doi: 10.2165/00002018-199615020-00004. PMID: 8884163.
Copy Download .nbib Format: NLM
Share it on
Full text links
Springer

Drug Saf. 1996 Aug;15(2):116-34. doi: 10.2165/00002018-199615020-00004.

A risk-benefit assessment of drugs used in the management of obsessive-compulsive disorder.

Drug safety

L L Carpenter, C J McDougle, C N Epperson, L H Price

Affiliations

  1. Yale University Department of Psychiatry, Abraham Ribicoff Research Facilities, Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven, USA.

PMID: 8884163 DOI: 10.2165/00002018-199615020-00004

Abstract

Established efficacy and tolerability in large multicentre controlled studies have made serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SRIs) the mainstay of monotherapy for adult obsessive-compulsive disorder (OCD). When compared with the selective serotonin reuptake inhibitors (SSRIs), the tricyclic compound clomipramine has a higher incidence of adverse effects but is well tolerated by most OCD patients and may confer the best overall antiobsessional effects. Consideration of specific adverse effect profiles, special patient population characteristics, drug interactions and relative cost of the various agents may direct clinicians in choosing the most appropriate first-line drug. Alternative agents as monotherapies have been explored, but none has consistently proven effective to date. Investigations of SRI augmentation with serotonin-enhancing agents have also failed to demonstrate substantial benefits for treatment-refractory OCD. Combination treatment with SRIs and dopamine receptor antagonist drugs appears to provide an improved response for the subpopulation of OCD patients who have comorbid 'tic-spectrum' disorders, though large-scale studies of the efficacy and tolerability of these regimens are not yet available.

References

  1. Pharmacopsychiatry. 1984 Mar;17(2):61-2 - PubMed
  2. J Am Acad Child Adolesc Psychiatry. 1994 Mar-Apr;33(3):342-8 - PubMed
  3. J Clin Psychiatry. 1987 Oct;48 Suppl:50-6 - PubMed
  4. J Clin Psychiatry. 1993 Jun;54 Suppl:4-9 - PubMed
  5. Neurology. 1991 Jun;41(6):872-4 - PubMed
  6. Arch Gen Psychiatry. 1983 Jun;40(6):605-12 - PubMed
  7. J Clin Psychiatry. 1992 Apr;53 Suppl:29-37 - PubMed
  8. J Clin Psychiatry. 1996;57 Suppl 8:17-24; discussion 25 - PubMed
  9. Arch Gen Psychiatry. 1980 Nov;37(11):1281-5 - PubMed
  10. Am J Psychiatry. 1982 Mar;139(3):364-5 - PubMed
  11. Am J Psychiatry. 1986 Mar;143(3):317-22 - PubMed
  12. Arch Gen Psychiatry. 1996 Jul;53(7):653-4 - PubMed
  13. J Clin Psychopharmacol. 1991 Aug;11(4):242-8 - PubMed
  14. J Clin Psychopharmacol. 1992 Dec;12(6):420-30 - PubMed
  15. Lancet. 1955 Apr 16;268(6868):781-5 - PubMed
  16. Arch Gen Psychiatry. 1990 Jun;47(6):577-85 - PubMed
  17. Can Med Assoc J. 1970 Jul 18;103(2):167-8 - PubMed
  18. Arch Gen Psychiatry. 1991 Oct;48(10):922-7 - PubMed
  19. J Clin Psychopharmacol. 1996 Feb;16(1):81-4 - PubMed
  20. Ann Neurol. 1979 Jul;6(1):37-9 - PubMed
  21. J Clin Psychiatry. 1993 Jun;54 Suppl:16-26 - PubMed
  22. Am J Psychiatry. 1989 Dec;146(12):1637 - PubMed
  23. J Am Acad Child Adolesc Psychiatry. 1992 Jan;31(1):45-9 - PubMed
  24. Arch Gen Psychiatry. 1991 Aug;48(8):730-8 - PubMed
  25. Brain Res. 1989 Dec 29;505(2):351-3 - PubMed
  26. J Am Acad Child Adolesc Psychiatry. 1995 Jan;34(1):36-44 - PubMed
  27. Am J Psychiatry. 1995 Sep;152(9):1359-61 - PubMed
  28. J Clin Psychiatry. 1988 Nov;49(11):458 - PubMed
  29. Arch Gen Psychiatry. 1989 Dec;46(12):1088-92 - PubMed
  30. Aust N Z J Psychiatry. 1991 Sep;25(3):412-4 - PubMed
  31. J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug;33(6):792-4 - PubMed
  32. Am J Psychiatry. 1990 Sep;147(9):1209-15 - PubMed
  33. Arch Gen Psychiatry. 1989 Nov;46(11):1006-11 - PubMed
  34. Am J Psychiatry. 1986 Jan;143(1):18-23 - PubMed
  35. Am J Psychiatry. 1984 Oct;141(10):1283-5 - PubMed
  36. J Clin Psychiatry. 1993 Jun;54 Suppl:27-9; discussion 30 - PubMed
  37. J Am Acad Child Psychiatry. 1979 Spring;18(2):320-41 - PubMed
  38. Am J Psychiatry. 1990 Mar;147(3):370-1 - PubMed
  39. Psychopharmacol Bull. 1990;26(2):211-4 - PubMed
  40. J Clin Psychopharmacol. 1994 Jun;14(3):209-11 - PubMed
  41. J Clin Psychopharmacol. 1987 Aug;7(4):278-9 - PubMed
  42. Am J Psychiatry. 1987 Aug;144(8):1059-61 - PubMed
  43. J Am Acad Child Adolesc Psychiatry. 1992 Nov;31(6):1062-9 - PubMed
  44. J Clin Psychiatry. 1990 Aug;51 Suppl:36-43; discussion 55-8 - PubMed
  45. J Am Acad Child Adolesc Psychiatry. 1993 Jan;32(1):211-4 - PubMed
  46. Am J Psychiatry. 1995 Dec;152(12):1812-4 - PubMed
  47. Eur Neuropsychopharmacol. 1993 Jun;3(2):143-52 - PubMed
  48. Clin Neuropharmacol. 1990 Aug;13(4):322-8 - PubMed
  49. Am J Psychiatry. 1988 Dec;145(12):1521-5 - PubMed
  50. Compr Psychiatry. 1986 May-Jun;27(3):211-4 - PubMed
  51. Ann N Y Acad Sci. 1978 Jun 12;305:222-41 - PubMed
  52. J Clin Psychopharmacol. 1985 Feb;5(1):39-42 - PubMed
  53. Arch Gen Psychiatry. 1992 Nov;49(11):862-6 - PubMed
  54. Am J Psychiatry. 1993 Apr;150(4):647-9 - PubMed
  55. Brain Res. 1989 Jun 26;490(2):255-67 - PubMed
  56. Am J Psychiatry. 1993 May;150(5):819-21 - PubMed
  57. J Am Acad Child Adolesc Psychiatry. 1995 Nov;34(11):1460-8 - PubMed
  58. Am J Psychiatry. 1988 Aug;145(8):1015-7 - PubMed
  59. J Am Acad Child Adolesc Psychiatry. 1994 Jan;33(1):143-4 - PubMed
  60. Arch Gen Psychiatry. 1994 Apr;51(4):302-8 - PubMed
  61. J Clin Psychopharmacol. 1994 Feb;14(1):1-4 - PubMed
  62. Br J Psychiatry. 1990 Nov;157:762-5 - PubMed
  63. J Clin Psychopharmacol. 1992 Jun;12(3):156-62 - PubMed
  64. Psychopharmacol Bull. 1989;25(2):209-12 - PubMed
  65. Neurosci Lett. 1988 Aug 1;90(3):285-91 - PubMed
  66. Am J Psychiatry. 1995 Dec;152(12):1832 - PubMed
  67. J Clin Psychiatry. 1990 Apr;51(4):168-9 - PubMed
  68. Can Med Assoc J. 1970 Sep 26;103(6):650-1 - PubMed
  69. Arch Gen Psychiatry. 1994 Jul;51(7):559-67 - PubMed
  70. Arch Gen Psychiatry. 1985 Oct;42(10):977-83 - PubMed
  71. Arch Gen Psychiatry. 1989 Jan;46(1):36-44 - PubMed
  72. Am J Psychiatry. 1982 Oct;139(10):1345-6 - PubMed
  73. Br J Psychiatry. 1987 Jul;151:107-12 - PubMed
  74. Am J Psychiatry. 1987 Dec;144(12):1543-8 - PubMed
  75. J Clin Psychiatry. 1989 Jul;50(7):265-6 - PubMed
  76. Br J Psychiatry. 1995 Apr;166(4):424-43 - PubMed
  77. Am J Psychiatry. 1990 Jul;147(7):923-8 - PubMed
  78. J Clin Psychiatry. 1990 Mar;51(3):119-23 - PubMed
  79. Arch Gen Psychiatry. 1995 Apr;52(4):289-95 - PubMed
  80. Psychopharmacology (Berl). 1992;109(1-2):2-11 - PubMed
  81. J Clin Psychiatry. 1994 Mar;55 Suppl:24-31 - PubMed
  82. Pharmacopsychiatry. 1991 Jan;24(1):21-7 - PubMed
  83. N Engl J Med. 1990 Mar 29;322(13):869-73 - PubMed
  84. Br J Psychiatry. 1992 Nov;161:665-70 - PubMed
  85. Am J Psychiatry. 1991 Jan;148(1):127-9 - PubMed
  86. Arch Gen Psychiatry. 1983 Dec;40(12):1335-42 - PubMed
  87. Acta Psychiatr Scand. 1984 Mar;69(3):259-61 - PubMed
  88. J Clin Psychiatry. 1992 Apr;53 Suppl:11-6 - PubMed
  89. Br J Psychiatry. 1992 Feb;160:283-4 - PubMed
  90. J Clin Psychopharmacol. 1990 Apr;10(2):122-4 - PubMed
  91. Biol Psychiatry. 1985 Nov;20(11):1174-88 - PubMed
  92. Arch Gen Psychiatry. 1995 Jan;52(1):53-60 - PubMed
  93. J Clin Psychopharmacol. 1985 Aug;5(4):207-12 - PubMed
  94. J Am Acad Child Adolesc Psychiatry. 1993 Jul;32(4):792-7 - PubMed
  95. Arch Gen Psychiatry. 1989 Jan;46(1):20-2 - PubMed
  96. Clin Pharmacol Ther. 1994 Nov;56(5):471-6 - PubMed
  97. N Engl J Med. 1986 Oct 16;315(16):993-7 - PubMed
  98. J Clin Psychopharmacol. 1992 Feb;12(1):65-6 - PubMed
  99. J Am Acad Child Adolesc Psychiatry. 1990 Jan;29(1):45-8 - PubMed
  100. J Am Acad Child Adolesc Psychiatry. 1993 Mar;32(2):470-1 - PubMed
  101. Am J Psychiatry. 1988 Oct;145(10):1285-6 - PubMed
  102. Psychopathology. 1987;20 Suppl 1:114-22 - PubMed
  103. J Pharmacol Exp Ther. 1983 Sep;226(3):686-700 - PubMed
  104. J Clin Psychopharmacol. 1991 Jun;11(3):175-84 - PubMed
  105. Biol Psychiatry. 1988 Jan 15;23(2):181-5 - PubMed
  106. J Clin Psychopharmacol. 1992 Feb;12(1):11-8 - PubMed
  107. J Neurol Neurosurg Psychiatry. 1985 Jan;48(1):65-9 - PubMed
  108. Am J Psychiatry. 1990 May;147(5):652-4 - PubMed
  109. Am J Psychiatry. 1988 Sep;145(9):1173-4 - PubMed
  110. Psychosomatics. 1983 Jul;24(7):671-3 - PubMed
  111. J Clin Psychiatry. 1990 Apr;51(4):158-61 - PubMed
  112. Prog Neuropsychopharmacol. 1981;5(3):257-62 - PubMed
  113. Am J Psychiatry. 1962 Oct;119:367-8 - PubMed
  114. J Clin Psychiatry. 1995 Nov;56(11):526-8 - PubMed
  115. Am J Psychiatry. 1990 Jun;147(6):798-800 - PubMed
  116. Arch Gen Psychiatry. 1989 Nov;46(11):1012-6 - PubMed
  117. Arch Gen Psychiatry. 1986 Dec;43(12):1180-2 - PubMed
  118. J Clin Psychiatry. 1991 Jan;52(1):13-4 - PubMed
  119. J Clin Psychiatry. 1983 Apr;44(4):131-2 - PubMed
  120. J Clin Psychopharmacol. 1995 Apr;15(2):125-31 - PubMed
  121. Psychiatry Res. 1985 Jan;14(1):85-93 - PubMed
  122. Psychopharmacol Bull. 1990;26(3):279-84 - PubMed
  123. Psychosomatics. 1986 Dec;27(12):858-9 - PubMed
  124. Clin Pharmacokinet. 1994 Jul;27(1):1-5 - PubMed
  125. Int Clin Psychopharmacol. 1986 Apr;1(2):170-3 - PubMed
  126. Arch Gen Psychiatry. 1987 Mar;44(3):219-25 - PubMed
  127. Arch Gen Psychiatry. 1990 Oct;47(10):926-32 - PubMed
  128. Am J Psychiatry. 1986 Apr;143(4):530-2 - PubMed
  129. Psychopharmacol Bull. 1989;25(1):36-40 - PubMed
  130. Biol Psychiatry. 1987 Jun;22(6):667-87 - PubMed
  131. J Am Acad Child Adolesc Psychiatry. 1996 Jun;35(6):701-2 - PubMed
  132. J Clin Psychopharmacol. 1993 Oct;13(5):354-8 - PubMed
  133. J Clin Psychiatry. 1994 Jul;55(7):301-5 - PubMed
  134. Prog Neuropsychopharmacol. 1981;5(2):129-38 - PubMed
  135. J Clin Psychopharmacol. 1990 Apr;10(2):152-3 - PubMed

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources