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Williams L, Hill DP, Davis JA, et al. The influence of food on the absorption and metabolism of drugs: an update. Eur J Drug Metab Pharmacokinet. 1996;21(3):201-11doi: 10.1007/BF03189714.
Williams, L., Hill, D. P., Davis, J. A., & Lowenthal, D. T. (1996). The influence of food on the absorption and metabolism of drugs: an update. European journal of drug metabolism and pharmacokinetics, 21(3), 201-11. https://doi.org/10.1007/BF03189714
Williams, L, et al. "The influence of food on the absorption and metabolism of drugs: an update." European journal of drug metabolism and pharmacokinetics vol. 21,3 (1996): 201-11. doi: https://doi.org/10.1007/BF03189714
Williams L, Hill DP, Davis JA, Lowenthal DT. The influence of food on the absorption and metabolism of drugs: an update. Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):201-11. doi: 10.1007/BF03189714. PMID: 8980916.
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Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):201-11. doi: 10.1007/BF03189714.

The influence of food on the absorption and metabolism of drugs: an update.

European journal of drug metabolism and pharmacokinetics

L Williams, D P Hill, J A Davis, D T Lowenthal

Affiliations

  1. Medicine Service, Department of Veterans Affairs Medical Center, Bay Pines, FL 33504, USA.

PMID: 8980916 DOI: 10.1007/BF03189714

Abstract

Food-drug interactions can lead to a loss of therapeutic efficacy or toxic effects of drug therapy. Generally, the effect of food on drugs results in a reduction in the drug's bioavailability; however, food can also alter drug clearance. The benefits of considering metabolism and pharmacokinetic information in the drug discovery process have been highlighted by Humphrey and Smith (79) and the process of rational drug design should include considerations of the chemistry, pharmacology and pharmacokinetics of the drug (80) and the impact of diet on these parameters.

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