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Huang Q, He G, Lan Q, et al. Target imaging diagnosis of human brain glioma. Clinical analysis of 40 cases. Chin Med J (Engl). 1996;109(1):93-6
Huang, Q., He, G., Lan, Q., Li, X., Qian, Z., Chen, J., Lu, Z., & Du, Z. (1996). Target imaging diagnosis of human brain glioma. Clinical analysis of 40 cases. Chinese medical journal, 109(1), 93-6.
Huang, Q, et al. "Target imaging diagnosis of human brain glioma. Clinical analysis of 40 cases." Chinese medical journal vol. 109,1 (1996): 93-6.
Huang Q, He G, Lan Q, Li X, Qian Z, Chen J, Lu Z, Du Z. Target imaging diagnosis of human brain glioma. Clinical analysis of 40 cases. Chin Med J (Engl). 1996 Jan;109(1):93-6. PMID: 8758379.
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Chin Med J (Engl). 1996 Jan;109(1):93-6.

Target imaging diagnosis of human brain glioma. Clinical analysis of 40 cases.

Chinese medical journal

Q Huang, G He, Q Lan, X Li, Z Qian, J Chen, Z Lu, Z Du

Affiliations

  1. Department of Neurosurgery, Second Affiliated Hospital, Suzhou Medical College.

PMID: 8758379

Abstract

OBJECTIVE: To establish a method for localization and qualitative diagnosis of glioma.

METHODS: The monoclonal antibody SZ-39 against human glioma was labelled with 131I and injected intravenously into 40 patients with intracranial occupying lesions proved by X-CT. 72 hours after 131I-McAb-SZ39 administration, cranial bone nuclide-imaging agent 99mTc-MDP was injected intravenously, and the patients were examined by SPECT scan with dual nuclide double channel tomography and special software. On radio-immuno-image, the immunocomplex formed by specific conjugation of 131I-McAb-SZ39 with target tissue was red, while the cranial bone incorporated with 99mTc-MDP was green. The location of the immunocomplex area could be identified by the superimposition of the images.

RESULTS: 21 patients with positive targeting diagnosis of glioma showed the accuracy rate checked by SPECT was 81%(17/21) and by X-CT 48% (10/21). Seven patients with negative targeting diagnosis showed the accuracy rate checked by SPECT was 86%(6/7) and by X-CT 14% (1/7). Pathologically, the sensitivity of targeting SPECT to glioma was 94.5%(17/18) and that of X-CT 55%(10/18).

CONCLUSIONS: Targeting SPECT examination could be used for localization and qualitative diagnosis of glioma and make up the inadequacy of X-CT in the qualitative diagnosis of atypical incipient and recurrent glioma, meningioma, metastatic carcinoma, and inflammatory lesions of brain.

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