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Kalsbeek A, van Heerikhuize JJ, Wortel J, et al. A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist. J Neurosci. 1996;16(17):5555-65
Kalsbeek, A., van Heerikhuize, J. J., Wortel, J., & Buijs, R. M. (1996). A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist. The Journal of neuroscience : the official journal of the Society for Neuroscience, 16(17), 5555-65.
Kalsbeek, A, et al. "A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist." The Journal of neuroscience : the official journal of the Society for Neuroscience vol. 16,17 (1996): 5555-65.
Kalsbeek A, van Heerikhuize JJ, Wortel J, Buijs RM. A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist. J Neurosci. 1996 Sep 01;16(17):5555-65. PMID: 8757267; PMCID: PMC6578885.
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J Neurosci. 1996 Sep 01;16(17):5555-65.

A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist.

The Journal of neuroscience : the official journal of the Society for Neuroscience

A Kalsbeek, J J van Heerikhuize, J Wortel, R M Buijs

Affiliations

  1. Netherlands Institute for Brain Research, Amsterdam, The Netherlands.

PMID: 8757267 PMCID: PMC6578885
Free PMC Article

Abstract

The mammalian suprachiasmatic nuclei (SCN) contain an endogenous pacemaker that generates daily rhythms in behavior and secretion of hormones. We hypothesized that the SCN imposes its circadian rhythm on the rest of the brain via a rhythmic release of its transmitters in its target areas. Previously, we demonstrated a pronounced inhibitory effect of vasopressin (VP), released from SCN terminals in the dorsomedial hypothalamus, on the release of the adrenal hormone corticosterone. In the present study, microdialysis-mediated intracerebral administration of the VP V1-receptor antagonist was used to pursue the study of the mechanisms underlying the circadian control of basal corticosterone release. Using timed administrations of the VP antagonist divided equally over the day/night cycle, we were able to uncover the existence of an additional stimulatory input from the SCN to the hypothalamopituitary-adrenal (HPA) axis. Peak activity of this stimulatory SCN input takes place during the second half of the light period, after the daily peak of VP secretion, with a delay of approximately 4-6 hr. In all likelihood, the inhibitory and stimulatory circadian input via separate mechanisms affects corticosterone release. Together, these two opposing circadian control mechanisms of the HPA axis enable a precise timing of the circadian peak in corticosterone release.

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