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Li YJ, Yokawa T, Matthews KH, et al. Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties. Biomaterials. 1996;17(22):2179-89doi: 10.1016/0142-9612(96)00048-8.
Li, Y. J., Yokawa, T., Matthews, K. H., Chen, T. M., Wang, Y. F., Kodama, M., & Nakaya, T. (1996). Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties. Biomaterials, 17(22), 2179-89. https://doi.org/10.1016/0142-9612(96)00048-8
Li, Y J, et al. "Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties." Biomaterials vol. 17,22 (1996): 2179-89. doi: https://doi.org/10.1016/0142-9612(96)00048-8
Li YJ, Yokawa T, Matthews KH, Chen TM, Wang YF, Kodama M, Nakaya T. Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties. Biomaterials. 1996 Nov;17(22):2179-89. doi: 10.1016/0142-9612(96)00048-8. PMID: 8922604.
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Biomaterials. 1996 Nov;17(22):2179-89. doi: 10.1016/0142-9612(96)00048-8.

Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties.

Biomaterials

Y J Li, T Yokawa, K H Matthews, T M Chen, Y F Wang, M Kodama, T Nakaya

Affiliations

  1. Department of Bio-applied Chemistry, Faculty of Engineering, Osaka City University, Japan.

PMID: 8922604 DOI: 10.1016/0142-9612(96)00048-8

Abstract

New segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties were synthesized. The soft segments used in this study were the poly(butadiene), poly(isoprene) or hydrogenated poly(isoprene) glycols; the hard segments of these segmented polyurethanes were composed of 4,4'-methylenediphenyl diisocyanate, 2-[bis(2-hydroxyethyl)methylammonio]ethyl 5-cholesten-3 beta-yl phosphate and 1,4-butanediol. The blood compatibilities of synthesized segmented polyurethanes were evaluated by platelet-rich plasma contact studies and scanning electron microscopy observation using glass as the reference. The results show that the blood compatibilities of the synthesized segmented polyurethanes have great difference between the glass contact side and air exposed side for the same cast films. Generally, the hydrogenated poly(isoprene)-based segmented polyurethane is the best surface in terms of platelet adhesion, and the morphology of adhered platelets undergoes the lowest degree of variation among the segmented polyurethanes investigated in this study.

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